scholarly journals Clinical Features of Miller-Fisher Syndrome in Pregnancy

2015 ◽  
Vol 2015 ◽  
pp. 1-3
Author(s):  
Masanori Ono ◽  
Hideki Sato ◽  
Mayu Shirahashi ◽  
Noriko Tomioka ◽  
Julia Maeda ◽  
...  
Keyword(s):  
Clinical Features ◽  
Pregnant Patient ◽  
Acute Onset ◽  
Accurate Diagnosis ◽  
Miller Fisher Syndrome ◽  
The West ◽  
Fisher Syndrome ◽  
Brainstem Stroke ◽  
Clinical Triad ◽  
Patient’S History

Miller-Fisher syndrome (MFS) is recognized as a variant of Guillain-Barré syndrome (GBS). MFS is a rare disorder that is characterized by the acute onset of ophthalmoplegia, ataxia, and areflexia/hyporeflexia. MFS has a higher incidence in Asia, where the incidence is estimated to be 18%–26% of GBS compared with 3%–5% in the West. The differential diagnosis of MFS includes Wernicke’s encephalopathy (WE) which is characterized by a clinical triad (nystagmus and ophthalmoplegia, mental status changes, and ataxia), myasthenia gravis, and brainstem stroke. The association between MFS and pregnancy has not been reported previously. Here, we describe the clinical features of a pregnant woman in early pregnancy with MFS. This case highlights the fact that it is necessary to establish an accurate diagnosis based on the details from the patient’s history on appropriate complementary testing in a pregnant patient with MFS.

scholarly journals Miller Fisher syndrome developed after a previous COVID-19 infection (case report)

2021 ◽  
Vol 11 (2) ◽  
pp. 56-60
Author(s):  
V. A. Malko ◽  
P. V. Klimov ◽  
M. P. Topuzova ◽  
I.  V. Yarush ◽  
K. V. Simakov ◽  
...  
Keyword(s):  
Clinical Case ◽  
Clinical Manifestations ◽  
Acute Onset ◽  
Miller Fisher Syndrome ◽  
Complete Regression ◽  
Speech Impairment ◽  
Fisher Syndrome ◽  
Coronavirus Infection ◽  
Clinical Triad ◽  
Classical Triad

Miller Fisher syndrome is one of the forms of Guillain–Barrе́ syndrome, characterized by a clinical triad that includes ophthalmoplegia, ataxia and areflexia, with the possible addition of moderate peripheral tetraparesis. During the year that has passed since the start of the pandemic of the new coronavirus infection COVID‑19, international publications have presented a few cases of Miller Fisher syndrome, which developed in patients at different times after the COVID‑19 infection – from 3–5 days to 3 weeks. The article presents a description of a clinical case of Miller Fisher syndrome, which occurred with 34‑year‑old man 21 days after the COVID‑19 infection. The clinical manifestations of Miller Fisher syndrome were typical and included diplopia, areflexia, and ataxia. At the beginning of the disease, there was a transient episode of speech impairment in the form of mild dysarthria. Oculomotor disorders predominated in the clinical picture over other components of the classical triad. On the background of treatment with human immunoglobulin G, there was a complete regression of symptoms.This description of Miller Fisher syndrome, which developed after the postponed infection with COVID‑19, is the first in Russia. The presented case demonstrates the ability of the SARS‑CoV‑2 virus to induce the development of an autoimmune disease. Practitioners should take into account the possibility of Miller Fisher syndrome developing in the event of an acute onset of diplopia, ataxia and areflexia in patients after a previous COVID‑19 infection.

scholarly journals A rare mimic of acute stroke: rapidly progressing Miller-Fisher Syndrome to acute motor and sensory axonal neuropathy variant of Guillain-Barre Syndrome

2019 ◽  
Vol 12 (3) ◽  
pp. e228220
Author(s):  
Lennie Lynn Chua de Castillo ◽  
Jose Danilo Bengzon Diestro ◽  
Katrina Hannah Dizon Ignacio ◽  
Paul Matthew Dimaguila Pasco
Keyword(s):  
Early Recognition ◽  
Axonal Neuropathy ◽  
Miller Fisher Syndrome ◽  
Guillain Barre Syndrome ◽  
Fisher Syndrome ◽  
Brainstem Stroke ◽  
Guillain Barré Syndrome ◽  
Initial Onset ◽  
Clinical Triad ◽  
Guillain Barré

Ophthalmoplegia, ataxia and areflexia characterise the clinical triad of Miller-Fisher Syndrome (MFS). When the disease presents acutely, it can mimic posterior circulation stroke. We describe a case of an adult patient presenting with sudden dizziness, diplopia, vomiting, and loss of balance. She was initially managed as a case of a brainstem stroke, but the progression of craniopathies without deterioration in sensorium coupled with areflexia clinched the diagnosis of MFS two days into her admission. On the third day, her MFS progressed rapidly to acute motor and sensory axonal neuropathy (AMSAN) variant of Guillain-Barre Syndrome, a rare occurrence in patients with MFS, with only four reported cases including our own. Among the four cases, ours is the only one still non-ambulatory eight months after the initial onset of symptoms. The case highlights the importance of early recognition of MFS in patients with ophthalmoplegia and ataxia despite initially normal reflexes.

scholarly journals The Differential Diagnosis of Acute Onset Truncal Ataxia: The Importance of Dysgeusia in Miller Fisher Syndrome

2018 ◽  
Vol 57 (14) ◽  
pp. 2057-2060 ◽  
Author(s):  
Tatsuya Ueno ◽  
Ryoya Kimura ◽  
Tomoya Kon ◽  
Rie Haga ◽  
Haruo Nishijima ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Acute Onset ◽  
Miller Fisher Syndrome ◽  
Fisher Syndrome ◽  
Truncal Ataxia

scholarly journals Miller-Fisher Syndrome: Are Anti-GAD Antibodies Implicated in Its Pathophysiology?

2016 ◽  
Vol 2016 ◽  
pp. 1-3 ◽  
Author(s):  
Ioannis E. Dagklis ◽  
Sotirios Papagiannopoulos ◽  
Varvara Theodoridou ◽  
Dimitrios Kazis ◽  
Ourania Argyropoulou ◽  
...  
Keyword(s):  
Clinical Features ◽  
Gamma Globulin ◽  
Miller Fisher Syndrome ◽  
Acid Decarboxylase ◽  
Gad Antibodies ◽  
Fisher Syndrome ◽  
Future Studies ◽  
Neurological Improvement ◽  
Intravenous Gamma Globulin

Miller-Fisher syndrome (MFS) is considered as a variant of the Guillain-Barre syndrome (GBS) and its characteristic clinical features are ophthalmoplegia, ataxia, and areflexia. Typically, it is associated with anti-GQ1b antibodies; however, a significant percentage (>10%) of these patients are seronegative. Here, we report a 67-year-old female patient who presented with the typical clinical features of MFS. Workup revealed antibodies against glutamic acid decarboxylase (GAD) in relatively high titers while GQ1b antibodies were negative. Neurological improvement was observed after intravenous gamma globulin and follow-up examinations showed a continuous clinical amelioration with simultaneous decline of anti-GAD levels which finally returned to normal values. This case indicates that anti-GAD antibodies may be associated with a broader clinical spectrum and future studies in GQ1b-seronegative patients could determine ultimately their clinical and pathogenetic significance in this syndrome.

Clinical features and prognosis of Miller Fisher syndrome

Neurology ◽  
2001 ◽  
Vol 56 (8) ◽  
pp. 1104-1106 ◽  
Author(s):  
M. Mori ◽  
S. Kuwabara ◽  
T. Fukutake ◽  
N. Yuki ◽  
T. Hattori
Keyword(s):  
Clinical Features ◽  
Miller Fisher Syndrome ◽  
Fisher Syndrome

scholarly journals Miller Fisher variant of Guillain Barre Syndrome: A Case Report

2016 ◽  
Vol 10 (1) ◽  
pp. 44-45
Author(s):  
Radheshyam Saha ◽  
Suranjit Kumar Saha ◽  
Muhammad Nurul Islam ◽  
Mohammad Rafiqul Kabir ◽  
Aniruddha Mondal ◽  
...  
Keyword(s):  
Case Report ◽  
Tract Infection ◽  
Respiratory Tract ◽  
Respiratory Tract Infection ◽  
Acute Onset ◽  
Miller Fisher Syndrome ◽  
Fisher Syndrome ◽  
History Of ◽  
Tendon Reflexes ◽  
Csf Examination

Miller Fisher Syndrome (MFS) is characterized by acute onset of ophthalmoplegia, ataxia and loss of tendon reflexes with relative sparing of strength in the extremities and trunk. Our patient Mr. Akter Sheikh, 40 years male, non diabetic, non hypertensive, presented with generalized weakness and difficulty in walking for 7 days preceded by a history of respiratory tract infection. After clinical and CSF examination, he was diagnosed as a case of Miller-Fisher syndrome. With treatment he improved significantly.Faridpur Med. Coll. J. Jan 2015;10(1): 44-45

scholarly journals Miller Fisher Syndrome: a case report

2017 ◽  
Vol 4 (4) ◽  
pp. 1193
Author(s):  
Shubhransu Patro ◽  
Vipin S. ◽  
Pankaj K. Khora ◽  
Payod K. Jena
Keyword(s):  
Case Report ◽  
Clinical Diagnosis ◽  
Clinical Features ◽  
Antibody Titer ◽  
Conservative Management ◽  
Recovery Phase ◽  
Miller Fisher Syndrome ◽  
Fisher Syndrome ◽  
Positive Serum ◽  
History Of

Miller Fisher Syndrome (MFS) is an uncommon variant of Guillain Barre syndrome (GBS). It is largely a clinical diagnosis based on the cardinal clinical features of ophthalmoplegia, ataxia and areflexia. The following case report is that of a patient who presented with an acute history of reeling of head, difficulty in opening the eyelids and swaying while walking, on clinical examination revealed the above-mentioned cardinal features and on investigation showed positive serum anti GQ1b antibody titer. The patient started recovering with conservative management and was discharged in the recovery phase.

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