Progress in quantitative methods based on liquid chromatography-mass spectrometry for drug metabolizing enzymes in human liver microsomes

Huanhuan WANG; Yayao LÜ; Bo PENG; Xiaohong QIAN; Yangjun ZHANG

doi:10.3724/sp.j.1123.2015.03023

Progress in quantitative methods based on liquid chromatography-mass spectrometry for drug metabolizing enzymes in human liver microsomes

Chinese Journal of Chromatography ◽

10.3724/sp.j.1123.2015.03023 ◽

2015 ◽

Vol 33 (6) ◽

pp. 553

Author(s):

Huanhuan WANG ◽

Yayao LÜ ◽

Bo PENG ◽

Xiaohong QIAN ◽

Yangjun ZHANG

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Human Liver ◽

Quantitative Methods ◽

Liver Microsomes ◽

Human Liver Microsomes ◽

Drug Metabolizing Enzymes ◽

Liquid Chromatography Mass Spectrometry ◽

Metabolizing Enzymes ◽

Chromatography Mass Spectrometry

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Methanol adducts leading to the identification of a reactive aldehyde metabolite of CPAQOP in human liver microsomes by ultra-high-performance liquid chromatography/mass spectrometry

Rapid Communications in Mass Spectrometry ◽

10.1002/rcm.7772 ◽

2016 ◽

Vol 31 (1) ◽

pp. 145-151 ◽

Cited By ~ 1

Author(s):

Scott Martin ◽

Eva M. Lenz ◽

Robin Smith ◽

David G. Temesi ◽

Alexandra L. Orton ◽

...

Keyword(s):

Mass Spectrometry ◽

High Performance Liquid Chromatography ◽

Liquid Chromatography ◽

Human Liver ◽

High Performance ◽

Liver Microsomes ◽

Human Liver Microsomes ◽

Liquid Chromatography Mass Spectrometry ◽

Chromatography Mass Spectrometry ◽

Reactive Aldehyde

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Study of in vitro metabolism of m-nisoldipine in human liver microsomes and recombinant cytochrome P450 enzymes by liquid chromatography–mass spectrometry

Journal of Pharmaceutical and Biomedical Analysis ◽

10.1016/j.jpba.2014.03.030 ◽

2014 ◽

Vol 97 ◽

pp. 65-71 ◽

Cited By ~ 20

Author(s):

Lin Yuan ◽

Peipei Jia ◽

Yupeng Sun ◽

Chengcheng Zhao ◽

Xuran Zhi ◽

...

Keyword(s):

Mass Spectrometry ◽

Cytochrome P450 ◽

Liquid Chromatography ◽

Human Liver ◽

Liver Microsomes ◽

Human Liver Microsomes ◽

In Vitro Metabolism ◽

Liquid Chromatography Mass Spectrometry ◽

Cytochrome P450 Enzymes

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In vitro metabolism of BYZX in human liver microsomes and the structural elucidation of metabolite by liquid chromatography–mass spectrometry method

Journal of Chromatography B ◽

10.1016/j.jchromb.2007.07.029 ◽

2007 ◽

Vol 857 (2) ◽

pp. 266-274 ◽

Cited By ~ 11

Author(s):

Zong-ling Xia ◽

Jing-yan Ying ◽

Rong Sheng ◽

Su Zeng ◽

Yong-zhou Hu ◽

...

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Human Liver ◽

Liver Microsomes ◽

Human Liver Microsomes ◽

In Vitro Metabolism ◽

Liquid Chromatography Mass Spectrometry ◽

Spectrometry Method ◽

Mass Spectrometry Method

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P450 interaction with farnesyl-protein transferase inhibitors metabolic stability, inhibitory potency, and P450 binding spectra in human liver microsomes 1 1Abbreviations: FTI, farnesyl-protein transferase inhibitor; FTase, farnesyl-protein transferase; and LC-MS, liquid chromatography-mass spectrometry.

Biochemical Pharmacology ◽

10.1016/s0006-2952(01)00724-9 ◽

2001 ◽

Vol 62 (6) ◽

pp. 773-776 ◽

Cited By ~ 15

Author(s):

Masato Chiba ◽

Cuyue Tang ◽

William E Neway ◽

Theresa M Williams ◽

S Jane Desolms ◽

...

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Human Liver ◽

Liver Microsomes ◽

Human Liver Microsomes ◽

Metabolic Stability ◽

Liquid Chromatography Mass Spectrometry ◽

Inhibitory Potency ◽

Farnesyl Protein Transferase ◽

Binding Spectra

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Use of SWATH-MS to relatively quantify the expression of hepatic drug metabolizing enzymes in human liver microsomes using a label-free approach

Drug Metabolism and Pharmacokinetics ◽

10.1016/j.dmpk.2017.11.195 ◽

2018 ◽

Vol 33 (1) ◽

pp. S57-S58

Author(s):

Rohitash Jamwal ◽

Benjamin J. Barlock ◽

Sravani Adusumalli ◽

Ken Ogasawara ◽

Brigitte L. Simons ◽

...

Keyword(s):

Human Liver ◽

Liver Microsomes ◽

Human Liver Microsomes ◽

Drug Metabolizing Enzymes ◽

Label Free ◽

Metabolizing Enzymes ◽

Hepatic Drug

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Identification of 7-Hydroperoxycholesterol in Human Liver by Liquid Chromatography-Mass Spectrometry

Alcoholism Clinical and Experimental Research ◽

10.1111/j.1530-0277.2000.tb00006.x ◽

2000 ◽

Vol 24 ◽

pp. 21S-25S ◽

Cited By ~ 7

Author(s):

Junko Adachi ◽

Migiwa Asano ◽

Yasuhiro Ueno ◽

Takeaki Naito

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Human Liver ◽

Liquid Chromatography Mass Spectrometry ◽

Chromatography Mass Spectrometry

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Study of the in vitro metabolic profile of a new α2-adrenergic agonist in rat and human liver microsomes by using liquid chromatography-multiple-stage mass spectrometry and nuclear magnetic resonance

Journal of Pharmaceutical and Biomedical Analysis ◽

10.1016/j.jpba.2019.03.067 ◽

2019 ◽

Vol 172 ◽

pp. 67-77

Author(s):

Josiane de O. Cardoso ◽

Bianca F. da Silva ◽

Tiago Venâncio ◽

Marina G. da Rocha Pitta ◽

Ivan da R. Pitta ◽

...

Keyword(s):

Mass Spectrometry ◽

Nuclear Magnetic Resonance ◽

Liquid Chromatography ◽

Magnetic Resonance ◽

Human Liver ◽

Metabolic Profile ◽

Liver Microsomes ◽

Human Liver Microsomes ◽

Adrenergic Agonist

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Investigation of the stereoselective metabolism of praziquantel after incubation with rat liver microsomes by capillary electrophoresis and liquid chromatography–mass spectrometry

Journal of Chromatography B Biomedical Sciences and Applications ◽

10.1016/s0378-4347(97)00638-5 ◽

1998 ◽

Vol 708 (1-2) ◽

pp. 267-275 ◽

Cited By ~ 26

Author(s):

Claudia Lerch ◽

Gottfried Blaschke

Keyword(s):

Mass Spectrometry ◽

Capillary Electrophoresis ◽

Liquid Chromatography ◽

Rat Liver ◽

Liver Microsomes ◽

Rat Liver Microsomes ◽

Liquid Chromatography Mass Spectrometry ◽

Stereoselective Metabolism ◽

Chromatography Mass Spectrometry

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Global Proteomic Analysis of Human Liver Microsomes: Rapid Characterization and Quantification of Hepatic Drug-Metabolizing Enzymes

Drug Metabolism and Disposition ◽

10.1124/dmd.116.074732 ◽

2017 ◽

Vol 45 (6) ◽

pp. 666-675 ◽

Cited By ~ 24

Author(s):

Brahim Achour ◽

Hajar Al Feteisi ◽

Francesco Lanucara ◽

Amin Rostami-Hodjegan ◽

Jill Barber

Keyword(s):

Proteomic Analysis ◽

Human Liver ◽

Liver Microsomes ◽

Human Liver Microsomes ◽

Drug Metabolizing Enzymes ◽

Metabolizing Enzymes ◽

Hepatic Drug ◽

Rapid Characterization

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Simultaneous Screening of Activities of Five Cytochrome P450 and Four Uridine 5′-Diphospho-glucuronosyltransferase Enzymes in Human Liver Microsomes Using Cocktail Incubation and Liquid Chromatography–Tandem Mass Spectrometry

Drug Metabolism and Disposition ◽

10.1124/dmd.114.063016 ◽

2015 ◽

Vol 43 (7) ◽

pp. 1137-1146 ◽

Cited By ~ 15

Author(s):

Boram Lee ◽

Hyeon-Kyeong Ji ◽

Taeho Lee ◽

Kwang-Hyeon Liu

Keyword(s):

Mass Spectrometry ◽

Cytochrome P450 ◽

Liquid Chromatography ◽

Tandem Mass Spectrometry ◽

Human Liver ◽

Liver Microsomes ◽

Human Liver Microsomes ◽

Tandem Mass ◽

Chromatography Tandem Mass Spectrometry ◽

Liquid Chromatography Tandem Mass

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