Dissociation of ketamine effects on rule acquisition and rule implementation: possible relevance to NMDA receptor contributions to executive cognitive functions

2000 ◽  
Vol 47 (2) ◽  
pp. 137-143 ◽  
Author(s):  
John H. Krystal ◽  
Alexandre Bennett ◽  
Danielle Abi-Saab ◽  
Aysenil Belger ◽  
Laurence P. Karper ◽  
...  
2015 ◽  
pp. 839 ◽  
Author(s):  
Naomi Ferreira ◽  
Paulo Januzzi Cunha ◽  
Danielle Irigoyen Costa ◽  
Fernando Santos ◽  
Fernanda Consolim-Colombo ◽  
...  

2009 ◽  
Vol 47 (13) ◽  
pp. 2916-2926 ◽  
Author(s):  
Daniel Romer ◽  
Laura Betancourt ◽  
Joan M. Giannetta ◽  
Nancy L. Brodsky ◽  
Martha Farah ◽  
...  

2003 ◽  
Vol 22 (6) ◽  
pp. 335-339 ◽  
Author(s):  
Namik Delibas ◽  
Irfan Altuntas ◽  
Zafer Yonden ◽  
Nurten Ozcelik

Ochratoxin A (OTA) is a mycotoxin produced by several fungi. Many foods can be contaminated by OTA, which is consequently found in the blood of humans and animals. It is known that OTA accumulates in the brain. The aim of this study was to investigate the effects of OTA on the brain. For this purpose, the effect of OTA on N-methyl-Daspartate (NMDA) receptor subunits 2A (NR2A) and 2B (NR2B) in the hippocampus and the protective effect of melatonin were investigated. Three groups of eight rats were used: controls, OTA-treated rats (OTA dose 289 mg/ kg per day) and OTA-melatonin-treated rats (melatonin dose 10 mg/kg per day). After four weeks of treatment, electrophoretic examinations were performed using SDSpolyacrylamide gel electrophoresis and Western blotting of hippocampal homogenates of the different groups. The concentrations of NR2A and NR2B in the OTA group were significantly lower than in the control group. The concentration of NR2B was significantly increased when melatonin was co-administered with OTA compared with OTA only. There was also a significant increase in NR2A levels when melatonin was co-administered with OTA. As a result, subchronic administration of OTA reduced hippocampal NMDA receptor subunits 2A and 2B concentrations in rats. It was thought that this alteration might affect cognitive functions because hippocampal NMDA receptors are involved in the memory and learning processes. Melatonin exhibited a partially protective effect on NR2A and NR2B against OTA.


2019 ◽  
Vol 26 (4) ◽  
pp. 353-363
Author(s):  
Yana Suchy ◽  
Jonathan Butner ◽  
Deborah J. Wiebe ◽  
MaryJane Campbell ◽  
Sara L. Turner ◽  
...  

AbstractObjectives:To examine the contributions of two aspects of executive functioning (executive cognitive functions and behavioral control) to changes in diabetes management across emerging adulthood.Methods:Two hundred and forty-seven high school seniors with type 1 diabetes were assessed at baseline and followed up for 3 years. The baseline assessment battery included performance-based measures of executive cognitive functions, behavioral control, IQ estimate (IQ-est), and psychomotor speed; self-report of adherence to diabetes regimen; and glycated hemoglobin (HbA1c) assay kits as a reflection of glycemic control.Results:Linear and quadratic growth curve models were used to simultaneously examine baseline performance on four cognitive variables (executive cognitive functions, behavioral control, IQ, and psychomotor speed) as predictors of indices of diabetes management (HbA1c and adherence) across four time points. Additionally, general linear regressions examined relative contributions of each cognitive variable at individual time points. The results showed that higher behavioral control at baseline was related to lower (better) HbA1c levels across all four time points. In contrast, executive cognitive functions at baseline were related to HbA1c trajectories, accounting for increasingly more HbA1c variance over time with increasing transition to independence. IQ-est was not related to HbA1c levels or changes over time, but accounted instead for HbA1c variance at baseline (while teens were still living at home), above and beyond all other variables. Cognition was unrelated to adherence.Conclusions:Different aspects of cognition play a different role in diabetes management at different time points during emerging adulthood years.


2013 ◽  
Vol 25 (5) ◽  
pp. 1348-1361 ◽  
Author(s):  
K. Blot ◽  
S.-i. Kimura ◽  
J. Bai ◽  
A. Kemp ◽  
D. Manahan-Vaughan ◽  
...  

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