Inhibition of interleukin-1β and prostaglandin E2 thermogenesis by glycyl-glutamine, a pro-opiomelanocortin-derived peptide

2001 ◽  
Vol 894 (2) ◽  
pp. 316-320 ◽  
Author(s):  
Garth E. Resch ◽  
William R. Millington
Keyword(s):  
Prostaglandin E2 ◽  
Interleukin 1Β

scholarly journals α-Ketoheterocycles Able to Inhibit the Generation of Prostaglandin E2 (PGE2) in Rat Mesangial Cells

Biomolecules ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 275
Author(s):  
Anastasia Psarra ◽  
Maria A. Theodoropoulou ◽  
Martin Erhardt ◽  
Marina Mertiri ◽  
Christiana Mantzourani ◽  
...  
Keyword(s):  
Prostaglandin E2 ◽  
Mesangial Cells ◽  
Cellular Level ◽  
Interleukin 1Β ◽  
Novel Agents

Prostaglandin E2 (PGE2) is a key mediator of inflammation, and consequently huge efforts have been devoted to the development of novel agents able to regulate its formation. In this work, we present the synthesis of various α-ketoheterocycles and a study of their ability to inhibit the formation of PGE2 at a cellular level. A series of α-ketobenzothiazoles, α-ketobenzoxazoles, α-ketobenzimidazoles, and α-keto-1,2,4-oxadiazoles were synthesized and chemically characterized. Evaluation of their ability to suppress the generation of PGE2 in interleukin-1β plus forskolin-stimulated mesangial cells led to the identification of one α-ketobenzothiazole (GK181) and one α-ketobenzoxazole (GK491), which are able to suppress the PGE2 generation at a nanomolar level.

The involvement of prostaglandin E2 in interleukin-1β evoked anorexia is strain dependent

2017 ◽  
Vol 60 ◽  
pp. 27-31 ◽  
Author(s):  
Anna Nilsson ◽  
Louise Elander ◽  
Martin Hallbeck ◽  
Unn Örtegren Kugelberg ◽  
David Engblom ◽  
...  
Keyword(s):  
Prostaglandin E2 ◽  
Interleukin 1Β ◽  
Strain Dependent ◽  
Is Strain

Interleukin-1β induction of tissue inhibitor of metalloproteinase (TIMP-1) is functionally antagonized by prostaglandin E2 in human synovial fibroblasts

1995 ◽  
Vol 57 (4) ◽  
pp. 619-629 ◽  
Author(s):  
John A. Dibattista ◽  
Jean-Pierre Pelletier ◽  
Muhammad Zafarullah ◽  
Kazushi Iwata ◽  
Johanne Martel-Pelletier
Keyword(s):  
Prostaglandin E2 ◽  
Synovial Fibroblasts ◽  
Tissue Inhibitor Of Metalloproteinase ◽  
Interleukin 1Β ◽  
Tissue Inhibitor
Sign in / Sign up

Export Citation Format

Share Document