As an important branch in the field of servo control, multi-motor coordination motion control applications are increasingly widespread. For open CNC system requirement, taking DSP as master core, combing with specific integrated stepper motor driver chip LMD18201T, this designed a serial communication-based new collaborative multi-motor control system, which has characters of highly integrated, good stability, real-time, convenient man-machine interface. The test results show that the system fully meet performance requirements and achieved the motion control functions.