Computed tomography of testicular tumours: Distribution of abdominal lymphadenopathy

Abstract Introduction Polyneuropathy is a key feature of polyneuropathy, organomegaly, endocrinopathy, monoclonal band, and skin changes syndrome, which is a paraneoplastic manifestation of an underlying lymphoproliferative neoplasm. We report the first case of polyneuropathy, organomegaly, endocrinopathy, monoclonal band, and skin changes syndrome presenting with a pseudosensory level. Case presentation A 59-year-old Tamil woman with long-standing diabetes mellitus and hypertension developed painless, progressive inguinal lymphadenopathy. A contrast-enhanced computed tomography scan showed mild hepatomegaly and intra-abdominal lymphadenopathy. A histological examination of an enlarged inguinal lymph node showed features of a plasma cell-type Castleman disease. She was treated with rituximab. Six months later, she developed gradually ascending numbness and weakness of both lower limbs. On examination, she had flaccid paraparesis (power 3/5) with a sensory level to pinprick at thoracic level 9. Joint position sense was preserved. Her cranial nerves and upper limbs were neurologically normal. Nerve conduction studies confirmed peripheral neuropathy with conduction slowing and a magnetic resonance imaging of her spine did not show cord or root compression. Serum protein electrophoresis showed a monoclonal band. A bone marrow biopsy showed a hypercellular marrow with 30% plasma cells. A repeat contrast-enhanced computed tomography scan showed sclerotic bony lesions involving multiple vertebrae in addition to mild hepatomegaly and intra-abdominal lymphadenopathy. Polyneuropathy, organomegaly, endocrinopathy, monoclonal band, and skin changes syndrome was diagnosed and she was treated with intravenously administered pulse therapy of dexamethasone and cyclophosphamide. After three cycles of treatment, she regained normal muscle power and sensation. Conclusions Polyneuropathy in polyneuropathy, organomegaly, endocrinopathy, monoclonal band, and skin changes syndrome can present as a pseudosensory level.

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Hypercalcaemia: A portent of sarcoidosis in cystic fibrosis

Sultan Qaboos University Medical Journal [SQUMJ] ◽

10.18295/squmj.2018.18.04.018 ◽

2019 ◽

Vol 18 (4) ◽

pp. 533

Author(s):

Jayakrishnan B. ◽

Saif M. Al-Mubaihsi ◽

Masoud S. Kashoub ◽

Jojy George

Keyword(s):

Computed Tomography ◽

Cystic Fibrosis ◽

Complete Resolution ◽

Oral Prednisolone ◽

Pulmonary Sarcoidosis ◽

University Hospital ◽

Converting Enzyme ◽

Sultan Qaboos University ◽

Abdominal Lymphadenopathy ◽

Early Manifestation

The coexistence of cystic fibrosis (CF) and sarcoidosis is rare. We report a 22-year-old male cystic fibrosis patient who presented multiple times to the Sultan Qaboos University Hospital, Muscat, Oman, in 2013. He was diagnosed with non-parathyroid-related hypercalcaemia and anterior uveitis, while computed tomography revealed mediastinal and abdominal lymphadenopathy and mild hepatosplenomegaly. These findings, in addition to the presence of calciuria and a high angiotensin-converting enzyme (ACE) level, confirmed a clinical diagnosis of sarcoidosis. The patient responded well to treatment with oral prednisolone which, over the course of two years, resulted in the near-complete resolution of parenchymal nodular infiltrates, regression of hilar lymphadenopathy, resolution of hypercalcaemia and the normalisation of his ACE levels. Diagnosing pulmonary sarcoidosis in CF can be challenging as most adult patients already have extensive lung disease. Physicians should be aware that hypercalcaemia may be an early manifestation of sarcoidosis in such cases.Keywords: Sarcoidosis; Cystic Fibrosis; Hypercalcemia; Case Report; Oman.

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Computed tomography in testicular tumours

Clinical Oncology ◽

10.1016/s0936-6555(05)80368-1 ◽

1994 ◽

Vol 6 (1) ◽

pp. 49-54 ◽

Cited By ~ 1

Author(s):

M.P. Williams ◽

C.A. Roobottom

Keyword(s):

Computed Tomography ◽

Testicular Tumours

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Low-Dose Computed Tomography Surveillance of Patients with Testicular Tumours

Clinical Oncology ◽

10.1016/j.clon.2003.11.004 ◽

2004 ◽

Vol 16 (2) ◽

pp. 158 ◽

Cited By ~ 13

Author(s):

R FitzGerald ◽

D Twiss ◽

R Mehra ◽

M Evans ◽

M Qaiyum ◽

...

Keyword(s):

Computed Tomography ◽

Low Dose ◽

Testicular Tumours ◽

Low Dose Computed Tomography

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X-ray microtomography

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100107058 ◽

1988 ◽

Vol 46 ◽

pp. 998-999

Author(s):

H.W. Deckman ◽

B.F. Flannery ◽

J.H. Dunsmuir ◽

K.D' Amico

Keyword(s):

Computed Tomography ◽

Internal Structure ◽

Imaging Technique ◽

Three Dimensional ◽

Tissue Structure ◽

Individual Element ◽

X Ray ◽

Non Invasive ◽

Panoramic Imaging ◽

Three Dimensional Images

We have developed a new X-ray microscope which produces complete three dimensional images of samples. The microscope operates by performing X-ray tomography with unprecedented resolution. Tomography is a non-invasive imaging technique that creates maps of the internal structure of samples from measurement of the attenuation of penetrating radiation. As conventionally practiced in medical Computed Tomography (CT), radiologists produce maps of bone and tissue structure in several planar sections that reveal features with 1mm resolution and 1% contrast. Microtomography extends the capability of CT in several ways. First, the resolution which approaches one micron, is one thousand times higher than that of the medical CT. Second, our approach acquires and analyses the data in a panoramic imaging format that directly produces three-dimensional maps in a series of contiguous stacked planes. Typical maps available today consist of three hundred planar sections each containing 512x512 pixels. Finally, and perhaps of most import scientifically, microtomography using a synchrotron X-ray source, allows us to generate maps of individual element.

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