scholarly journals Multiple roles for Hedgehog signaling in zebrafish pituitary development

2003 ◽  
Vol 254 (1) ◽  
pp. 19-35 ◽  
Author(s):  
Jennifer L Sbrogna ◽  
Michael J.F Barresi ◽  
Rolf O Karlstrom
Keyword(s):  
Hedgehog Signaling ◽  
Multiple Roles ◽  
Pituitary Development

The role of Notch and Hedgehog signaling pathways in pituitary development and pathogenesis of pituitary adenomas

HORMONES ◽  
2015 ◽  
Vol 14 (1) ◽  
pp. 5-18 ◽  
Author(s):  
Maria P. Yavropoulou ◽  
Anna Maladaki ◽  
John G. Yovos
Keyword(s):  
Signaling Pathways ◽  
Pituitary Adenomas ◽  
Hedgehog Signaling ◽  
Pituitary Development

Multiple roles of cholesterol in hedgehog signaling

2000 ◽  
Vol 151 (1) ◽  
pp. 237-238
Author(s):  
PhilipA. Beachy
Keyword(s):  
Hedgehog Signaling ◽  
Multiple Roles

scholarly journals Distinct roles of Bendless in regulating FSC niche competition and daughter cell differentiation

Development ◽  
2021 ◽  
Vol 148 (22) ◽  
Author(s):  
Sumitra Tatapudy ◽  
Jobelle Peralta ◽  
Todd Nystul
Keyword(s):  
Hedgehog Signaling ◽  
Adult Stem Cells ◽  
Proper Time ◽  
Single Gene ◽  
Multiple Roles ◽  
Cell Fates ◽  
Jnk Pathway ◽  
Jnk Signaling ◽  
Daughter Cells ◽  
Niche Competition

ABSTRACT A major goal in the study of adult stem cells is to understand how cell fates are specified at the proper time and place to facilitate tissue homeostasis. Here, we found that an E2 ubiquitin ligase, Bendless (Ben), has multiple roles in the Drosophila ovarian epithelial follicle stem cell (FSC) lineage. First, Ben is part of the JNK signaling pathway, and we found that it, as well as other JNK pathway genes, are essential for differentiation of FSC daughter cells. Our data suggest that JNK signaling promotes differentiation by suppressing the activation of the EGFR effector, ERK. Also, we found that loss of ben, but not the JNK kinase hemipterous, resulted in an upregulation of hedgehog signaling, increased proliferation and increased niche competition. Lastly, we demonstrate that the hypercompetition phenotype caused by loss of ben is suppressed by decreasing the rate of proliferation or knockdown of the hedgehog pathway effector, Smoothened (Smo). Taken together, our findings reveal a new layer of regulation in which a single gene influences cell signaling at multiple stages of differentiation in the early FSC lineage.

Microchemistry of ZnO Varistors

1992 ◽  
Vol 50 (2) ◽  
pp. 1694-1695
Author(s):  
K. K. Soni ◽  
J. Hwang ◽  
V. P. Dravid ◽  
T. O. Mason ◽  
R. Levi-Setti
Keyword(s):  
Grain Boundaries ◽  
Multiple Roles ◽  
Grain Boundary Engineering ◽  
Ion Microprobe ◽  
Dopant Distribution ◽  
Important Ingredient ◽  
Zno Varistor ◽  
Zno Varistors ◽  
Zno Powder ◽  
The University

ZnO varistors are made by mixing semiconducting ZnO powder with powders of other metal oxides e.g. Bi2O3, Sb2O3, CoO, MnO2, NiO, Cr2O3, SiO2 etc., followed by conventional pressing and sintering. The non-linear I-V characteristics of ZnO varistors result from the unique properties that the grain boundaries acquire as a result of dopant distribution. Each dopant plays important and sometimes multiple roles in improving the properties. However, the chemical nature of interfaces in this material is formidable mainly because often trace amounts of dopants are involved. A knowledge of the interface microchemistry is an essential component in the ‘grain boundary engineering’ of materials. The most important ingredient in this varistor is Bi2O3 which envelopes the ZnO grains and imparts high resistance to the grain boundaries. The solubility of Bi in ZnO is very small but has not been experimentally determined as a function of temperature.In this study, the dopant distribution in a commercial ZnO varistor was characterized by a scanning ion microprobe (SIM) developed at The University of Chicago (UC) which offers adequate sensitivity and spatial resolution.

667: Sonic Hedgehog Signaling Plays a Pivotal Role in the Vicious Cycle between Human Prostate Cancer and Normal/Benign but not Cancer Associated Human Prostate Stromal Cells

2007 ◽  
Vol 177 (4S) ◽  
pp. 224-224
Author(s):  
Katsumi Shigemura ◽  
Wen-Chin Haung ◽  
Fray F. Marshall ◽  
Haiyen E. Zhau ◽  
Leland W.K. Chung ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Sonic Hedgehog ◽  
Stromal Cells ◽  
Hedgehog Signaling ◽  
Pivotal Role ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Vicious Cycle ◽  
Sonic Hedgehog Signaling

Mental health effects of women's multiple roles.

1990 ◽  
Vol 45 (3) ◽  
pp. 381-384 ◽  
Author(s):  
Angela Barron McBride
Keyword(s):  
Mental Health ◽  
Health Effects ◽  
Multiple Roles ◽  
Mental Health Effects

Women's Multiple Roles: Source of Satisfaction or Stress?

2000 ◽  
Author(s):  
J. Reid ◽  
M. Hardy
Keyword(s):  
Multiple Roles

Multiple roles for attitudes under low and high elaboration

2014 ◽  
Author(s):  
Jeremy D. Gretton ◽  
Vanessa Sawicki ◽  
Leandre R. Fabrigar ◽  
Duane T. Wegener ◽  
Richard E. Petty ◽  
...  
Keyword(s):  
Multiple Roles
Sign in / Sign up

Export Citation Format

Share Document