Cerebrospinal Fluid Markers in the Management of Central Nervous System HIV Infection and the AIDS Dementia Complex

2014 ◽  
pp. 173-179
Author(s):  
Magnus Gisslén ◽  
Lars Hagberg ◽  
Paola Cinque ◽  
Bruce Brew ◽  
Richard W. Price
Keyword(s):  
Central Nervous System ◽  
Cerebrospinal Fluid ◽  
Nervous System ◽  
Hiv Infection ◽  
Aids Dementia Complex ◽  
Aids Dementia

scholarly journals Interleukin-6 and granulocyte macrophage-csf in the cerebrospinal fluid from hiv infected subjects with involvement of the central nervous system

1992 ◽  
Vol 50 (2) ◽  
pp. 180-182 ◽  
Author(s):  
O. Perrella ◽  
M. Guerriero ◽  
E. Izzo ◽  
M. Soscia ◽  
P. B. Carrieri
Keyword(s):  
Central Nervous System ◽  
Cerebrospinal Fluid ◽  
Interleukin 6 ◽  
Neurological Diseases ◽  
Aids Dementia Complex ◽  
Gm Csf ◽  
Aids Dementia ◽  
High Incidence ◽  
The Central Nervous System ◽  
Csf Levels

We detected the cytokines interleukin-6 (IL-6) and granulocyte macrophage-CSF (GM-CSF) by ELISA in the CSF and serum of 30 HIV-infected patients classified as AIDS dementia complex (ADC), and 20 subjects with other neurological diseases (OND). We have found a high incidence of detectable IL-6 and GM-CSF in the CSF of ADC patients compared with OND patients. No statistical differences were observed between both groups for serum IL-6 and GM-CSF levels. These results suggest an intrathecal synthesis of these cytokines and a possible involvement in the pathogenesis of ADC.

The brain in AIDS: central nervous system HIV-1 infection and AIDS dementia complex

Science ◽  
1988 ◽  
Vol 239 (4840) ◽  
pp. 586-592 ◽  
Author(s):  
R. Price ◽  
B Brew ◽  
J Sidtis ◽  
M Rosenblum ◽  
A. Scheck ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Aids Dementia Complex ◽  
Aids Dementia ◽  
The Brain ◽  
Hiv 1

Anomalies in Nef expression within the central nervous system of HIV-1 positive individuals/AIDS patients with or without AIDS dementia complex

1998 ◽  
Vol 4 (3) ◽  
pp. 291-300 ◽  
Author(s):  
Dale A Mcphee ◽  
Alison L Greenway ◽  
Gavan Holloway ◽  
Karen Smith ◽  
Nick Deacon ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Aids Dementia Complex ◽  
Aids Patients ◽  
Aids Dementia ◽  
The Central Nervous System ◽  
Hiv 1

Characteristics of cerebrospinal fluid under tuberculosis in patients with HIV-infection

2021 ◽  
Vol 13 (1) ◽  
pp. 53-58
Author(s):  
A. M. Panteleev ◽  
O. S. Sokolova ◽  
A. V. Zonova ◽  
S. A. Panteleeva ◽  
A. V. Lutsenko
Keyword(s):  
Central Nervous System ◽  
Cerebrospinal Fluid ◽  
Nervous System ◽  
Brain Injury ◽  
Hiv Infection ◽  
Protein Level ◽  
Saint Petersburg ◽  
Laboratory Changes ◽  
Cns Tuberculosis ◽  
Cd4 Lymphocytes

Purpose. To carry out an analysis of characteristics and to reveal the peculiarities of laboratory changes of cerebrospinal fluid (CSF) in patients with tuberculosis of central nervous system associated with HIV-infection.Materials and methods. Analysis of 206 patients with CNS tuberculosis associated with HIV-infection who were treated in State Budgetary Healthcare Institution «City tuberculosis hospital No. 2» of Saint Petersburg during the period from 2006 to 2018 was conducted.Results and discussion. It was concluded that a mean protein level in CSF was 1,6±0,1 g/l and was significantly increased in patients with tubercular meningoencephalomyelitis. When decreasing the amount of CD4-lymphocytes, increasing of protein level in cerebrospinal fluid is observed. As cytosis increases, the amount of neutrophils increases too. Patients with tuberculous meningitis showed remarkable pleocytosis in comparison with patients with meningocephalitis. In 47% of cases, neutrophilic cell composition of CSF was registered. Therewith, the rate of neutrophils in CSF increased as the rate of lymphocytes decreased. Reducing of glucose in CSF was observed in the majority of patients with CNS tuberculosis independently of severity of immunosuppression and extent of brain injury.

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