Determination of matrix metalloproteinase-2 and sex hormone in sera and peritoneal fluid of women with endometriosis and infertility of endometriosis

The aim of this study was to develop a new, label-free, highly selective Surface Plasmon Resonance Imaging biosensor for the quantitative determination of matrix metalloproteinase-2.

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DETERMINATION OF SERUM MATRIX METALLOPROTEINASE 2 AND 9 (MMP-2) (MMP-9) IN BREAST CANCER INVASION AND METASTASIS.

International Journal of Advanced Research ◽

10.21474/ijar01/8391 ◽

2019 ◽

Vol 7 (1) ◽

pp. 806-810

Author(s):

Rawan HamidJarrah ◽

◽

Dhamia KasimSuker ◽

Khairallah ASMohammed ◽

Rafid AdelAbood ◽

...

Keyword(s):

Breast Cancer ◽

Matrix Metalloproteinase ◽

Cancer Invasion ◽

Matrix Metalloproteinase 2 ◽

Invasion And Metastasis ◽

Breast Cancer Invasion

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The Role of Matrix Metalloproteinase2 (MMP2) in Serum and Peritoneal Fluid of Endometriotic Patients

Indonesian Journal of Obstetrics and Gynecology ◽

10.32771/inajog.v6i2.770 ◽

2018 ◽

pp. 104

Author(s):

NurIedil Baharuddin ◽

Nusratuddin Abdullah ◽

Telly Tessy ◽

St Maisuri T Chalid ◽

St Maisuri T Chalid

Keyword(s):

Matrix Metalloproteinase ◽

Peritoneal Fluid ◽

Obstet Gynecol ◽

Sampling Technique ◽

Matrix Metalloproteinase 2 ◽

Elisa Method ◽

Cross Sectional ◽

Consecutive Sampling ◽

Keywords Endometriosis

Objective: To determine the role of matrix metalloproteinase-2(MMP-2) in serum and peritoneal fluid of endometrioticpatients.Methods: Research’s design using cross-sectional method in Dr.Wahidin Sudirohusodo hospital and several other hospitals inMakassar within May 2015 until May 2016. Subjects were chosenusing consecutive sampling technique. The examination usingthe ELISA method. The data were analysed using Fisher exact,t-independent, Mann-Whitney, and Spearman association.Results: A total of 50 subjects were recruited in this study. Mostlythe value of MMP-2 serum and peritoneal fluid in endometriosisgroup was higher compare to study control. There was significantdifferent between the total of MMP-2 serum and peritoneal fluid.There was also a significant association between the value ofMMP-2 serum and peritoneal fluid with endometriosis.Conclusion: The value of MMP-2 serum and peritoneal fluid werehigher in endometriotic patients compared to those withoutendometriosis. The higher the value of MMP-2 serum andperitoneal fluid, the higher the stage of endometriosis.[Indones J Obstet Gynecol 2018; 6-2: 104-109]Keywords: endometriosis, matrix metalloproteinase-2, MMP-2

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Potential role of matrix metalloproteinase-2,-9 and tissue inhibitors of metalloproteinase-1,-2 in exudative pleural effusions

Clinical & Investigative Medicine ◽

10.25011/cim.v32i4.6621 ◽

2009 ◽

Vol 32 (4) ◽

pp. 293 ◽

Cited By ~ 15

Author(s):

S Vatansever ◽

R Gelisgen ◽

H Uzun ◽

S Yurt ◽

F Kosar

Keyword(s):

Pleural Effusion ◽

Matrix Metalloproteinase ◽

Pleural Fluid ◽

Matrix Metalloproteinase 2 ◽

Tissue Inhibitors ◽

Tissue Inhibitors Of Metalloproteinase ◽

Number Of Patients ◽

Diagnostic Values ◽

Tuberculous Pleurisy

Purpose: To investigate diagnostic values of pleural fluid matrix metalloproteinase-2 (MMP-2), MMP-9, tissue inhibitors of metalloproteinase-1 (TIMP-1) and TIMP-2 measurements in tuberculous pleurisy(TP) and malignat pleurisy (MP). Methods: The study included 24 patients with TP, 22 patients with MP and 15 patients with pleural effusion of non-tuberculous and non-malignant origin as controls. MMP-2,-9 and TIMP-1,-2 levels in pleural fluid were measured by ELISA method. Results: Pleural fluid MMP-2 and MMP-9 levels were higher (P < 0.001, P < 0.001, respectively) in TP than in MP and controls. MP patients have higher pleural fluid MMP-2 and MMP-9 levels (P < 0.01, P < 0.05, respectively) than controls. Pleural fluid TIMP-2 levels were higher (P < 0.01 and P < 0.001, respectively) in MP than in TP and controls. Pleural fluid MMP-9 levels were negatively correlated with pleural fluid TIMP-2 levels (r: 0.464, P=0.029) in patients with MP. Conclusions: Determination of TIMP-2 in pleural fluid may contribute to differentiate TP from MP. These results suggest that overproduction of MMP-9 and TIMP-2 is associated with accumulation of the pleural effusion in malignancy. Further studies with a greater number of patients are needed to confirm this hypothesis.

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