scholarly journals The Role of Matrix Metalloproteinase2 (MMP2) in Serum and Peritoneal Fluid of Endometriotic Patients

2018 ◽  
pp. 104
Author(s):  
NurIedil Baharuddin ◽  
Nusratuddin Abdullah ◽  
Telly Tessy ◽  
St Maisuri T Chalid ◽  
St Maisuri T Chalid
Keyword(s):  
Matrix Metalloproteinase ◽  
Peritoneal Fluid ◽  
Obstet Gynecol ◽  
Sampling Technique ◽  
Matrix Metalloproteinase 2 ◽  
Elisa Method ◽  
Cross Sectional ◽  
Consecutive Sampling ◽  
Keywords Endometriosis

Objective: To determine the role of matrix metalloproteinase-2(MMP-2) in serum and peritoneal fluid of endometrioticpatients.Methods: Research’s design using cross-sectional method in Dr.Wahidin Sudirohusodo hospital and several other hospitals inMakassar within May 2015 until May 2016. Subjects were chosenusing consecutive sampling technique. The examination usingthe ELISA method. The data were analysed using Fisher exact,t-independent, Mann-Whitney, and Spearman association.Results: A total of 50 subjects were recruited in this study. Mostlythe value of MMP-2 serum and peritoneal fluid in endometriosisgroup was higher compare to study control. There was significantdifferent between the total of MMP-2 serum and peritoneal fluid.There was also a significant association between the value ofMMP-2 serum and peritoneal fluid with endometriosis.Conclusion: The value of MMP-2 serum and peritoneal fluid werehigher in endometriotic patients compared to those withoutendometriosis. The higher the value of MMP-2 serum andperitoneal fluid, the higher the stage of endometriosis.[Indones J Obstet Gynecol 2018; 6-2: 104-109]Keywords: endometriosis, matrix metalloproteinase-2, MMP-2

scholarly journals HUBUNGAN PERAN KADER KESEHATAN JIWA DENGAN KEKAMBUHAN SKIZOFRENIA DI WILAYAH KERJA PUSKESMAS II DENPASAR TIMUR

2018 ◽  
Vol 5 (1) ◽  
pp. 128-137
Author(s):  
Anak Agung Ketut Parwati ◽  
Ni Ketut Ayu Mirayanti ◽  
Ni Ketut Citrawati
Keyword(s):  
Mental Health ◽  
Sampling Technique ◽  
Community Empowerment ◽  
Observational Research ◽  
P Value ◽  
Chi Square ◽  
Cross Sectional ◽  
Consecutive Sampling ◽  
Chi Square Test

Gangguan jiwa merupakan salah satu masalah kesehatan masyarakat di Indonesia. Prevalensi gangguan jiwa berat, seperti skizofrenia di Indonesia mencapai sekitar 400.000 orang atau sebanyak 1,7 per 1.000 penduduk. Seseorang yang pernah mengalami gangguan skizofrenia akan kembali kambuh karena kondisi yang tidak terkontrol dan tidak meminum obat secara rutin. Pemberdayaan masyarakat seperti kader kesehatan jiwa bermanfaat untuk mengidentifikasi dan mengatasi masalah serta mempertahankan kesehatan jiwa masyarakat. Penelitian ini bertujuan untuk mengetahui hubungan peran kader kesehatan jiwa dengan kekambuhan skizofrenia. Jenis penelitian ini termasuk penelitian observasional dengan pendekatan cross sectional. Penelitian dilakukan di wilayah kerja  Puskesmas II Denpasar Timur, teknik pengambilan sampel menggunakan consecutive sampling dengan sampel sebanyak 52 responden. Hasil penelitian didapatkan, kekambuhan skizofrenia sebanyak 30 orang (57,7%) tidak kambuh dan sebanyak 22 orang (42,3%) kambuh, untuk peran kader kesehatan jiwa kategori kurang sebanyak 31 orang (59,6%) dan kategori baik sebanyak 21 orang (40,4%). Hasil uji chi-square didapatkan angka p value sebesar 0,947 (p>0,05), menunjukkan tidak ada hubungan peran kader kesehatan jiwa dengan kekambuhan skizofrenia di wilayah kerja  Puskesmas II Denpasar Timur. Berdasarkan hasil penelitian ini disarankan untuk meningkatkan pemberdayaan kader kesehatan jiwa untuk membantu masyarakat mencapai kesehatan jiwa yang optimal.   Kata kunci : peran kader, kekambuhan skizofrenia   ABSTRACK Mental disorder is one of the public health problems in Indonesia. The prevalence of severe psychiatric disorders, such as schizophrenia in Indonesia reaches about 400.000 people or as many as 1.7 per 1.000 inhabitants. A person who has experienced schizophrenic disorder will recur because of uncontrolled conditions and not taking medication regularly. Community empowerment such as mental health cadres is useful to identify and solve problems and maintain the mental health of the community. The study aims to determine the relation of the role of mental health cadres with recurrence of schizophrenia. This type of research includes observational research with cross sectional approach. This research was conducted in the working area of Puskesmas II Denpasar Timur, sampling technique using consecutive sampling with the samples of 52 respondents. The result of the research showed that recurrence of  schizophrenia as many as 30 people (57,7%) did not relapse and as many as 22 people 42,3%) relapse, for the role of mental health cadre of less category as many 31 people (59,6%) and category both as many as 21 people (40,4%). chi-square test results obtained p value of 0,947 (P>0.05), showed no correlation role of mental health cadres with recurrence of schizophrenia in work area Puskesmas II Denpasar Timur. Based on the results of this study suggested to improve empowerment of mental health cadres to help people achieve optimal mental health.   Key words : role of cadres, recurrence of schizophrenia

scholarly journals PERBEDAAN KADAR MATRIX METALLOPROTEINASE-2 SERUM PADA KETUBAN PECAH DINI DAN KEHAMILAN NORMAL

2021 ◽  
Vol 4 (1) ◽  
pp. 36
Author(s):  
Ika Yulia Darma
Keyword(s):  
Matrix Metalloproteinase ◽  
Comparative Study ◽  
Matrix Metalloproteinase 2 ◽  
Cross Sectional ◽  
Consecutive Sampling

Ketuban pecah dini adalah masalah penting dalam obstetri dengan insiden 8 % pada kehamilan. Kejadian KPD disebabkan oleh muktifaktorial, diantaranya adalah faktor infeksi dan nutrisi ibu hamil yang mempengaruhi pembentukan selaput ketuban. Beberapa peneliti menemukan bahwa peningkatan matrix metalloproteinase-2  akan mendegradasi matrix extraseluler, menjadi lemah sehingga memicu terjadinya KPD. Tujuan penelitian untuk mengetahui hubungan MMP-2 serum dengan ketuban pecah dini dan kehamilan normal. Penelitian dilakukan dengan menggunakan desain cross sectional comparative study. Penelitian dilakukan pada empat rumah sakit di Padang pada bulan September – Oktober 2018. Pengambilan sampel dengan consecutive sampling. Populasi pada penelitian ini adalah ibu hamil dengan diagnosa ketuban pecah dini (n=29) dan seluruh wanita dengan kehamilan normal(n=29). Pemeriksaan MMP-2 dilakukan dengan metode ELISA. Uji statistik menggunakan uji t tidak berpasangan dan korelasi Pearson. Hasil penelitian menunjukkan rerata kadar MMP-2 pada KPD yaitu 35,17 ± 2,23 ng/ml, dan pada kehamilan normal 33,27 ± 0,82 ng/ml (p<0,05). Terdapat perbedaan kadar MMP-2 pada ketuban pecah dini dan kehamilan normal. Kesimpulan penelitian terdapat perbedaan rerata kadar MMP-2 pada ketuban pecah dini dan kehamilan normal.

Type I collagen from sea cucumber (Stichopus japonicus) and the role of matrix metalloproteinase-2 in autolysis

2021 ◽  
Vol 41 ◽  
pp. 100959
Author(s):  
Long-Jie Yan ◽  
Le-Chang Sun ◽  
Kai-Yuan Cao ◽  
Yu-Lei Chen ◽  
Ling-Jing Zhang ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Sea Cucumber ◽  
Type I Collagen ◽  
Matrix Metalloproteinase 2 ◽  
Type I ◽  
Stichopus Japonicus

Gambaran Tingkat Kecemasan Keluarga Merawat Pasien Dengan Skizofrenia

2021 ◽  
Vol 7 (01) ◽  
pp. 22-29
Author(s):  
Ni Nengah Nikawati ◽  
Ni Made Sri Muryani
Keyword(s):  
Family Members ◽  
Sampling Technique ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Descriptive Research ◽  
Consecutive Sampling ◽  
Normal Limits ◽  
Sense Of Security ◽  
Anxiety Levels ◽  
Severe Anxiety

Background: Anxiety is a feeling felt by respondents regarding disturbing mental tension, which as a general reaction with the inability to overcome a problem or there is no sense of security, which later leads to a physiological and psychological change. The level of family anxiety can be assessed by using a questionnaire with each respondent's characteristics and level of anxiety can be divided into several parts, namely: normal anxiety levels, mild anxiety levels, moderate anxiety levels, severe anxiety levels and panic. Objective: Knowing the description of the level of family anxiety in caring for patients with schizophrenia at the Mental Poliklinik UPTD. Rumah Sakit Jiwa Provinsi Bali and the characteristics of families caring for patients with schizophrenia based on education, age, and type of work. Methods: The research method that used in this study was descriptive research. This study used a cross sectional study, which was a study in which the subjects were evaluated only once and the measurement of each only one variable at the same time that using sampling consecutive sampling technique. The sample used was 32 people consisting of family members of hallucinations patients. Results: Based on research conducted at the Poliklinik UPTD. Rumah Sakit Jiwa Provinsi Bali toward 32 family members who was caring for patients by schizophrenia, most family members did not experience anxiety or anxiety in the normal range which was 29 family members of 32 family members and 3 families who experienced mild anxiety levels. Conclusion: That most family members who treated patients by schizophrenia at the Poliklinik UPTD. Rumah sakit Jiwa Provinsi Bali does not experience anxiety or anxiety still within normal limits. Latar Belakang: Kecemasan adalah suatu perasaan yang dirasakan oleh responden mengenai ketegangan mental yang menggelisahkan, dimana sebagai reaksi umum dengan ketidakmampuan dalam mengatasi suatu masalah atau tidak ada rasa aman, yang nantinya menimbulkan suatu perubahan fisiologis dan psikologis. Keluarga yang memiliki anggota keluarga dengan  gangguan jiwa dapat mengalami kecemasan Tingkat kecemasan keluarga dengan skizofrenia yaitu cemas ringan (80,49%) dan 8 keluarga mengalami cemas sedang (19,51%). Tujuan: Mengetahui gambaran tingkat kecemasan keluarga dalam merawat pasien dengan skizofrenia di Poliklinik Jiwa UPTD Rumah Sakit Jiwa Provinsi Bali dan karakteristik keluarga yang merawat pasien dengan skizofrenia berdasarkan pendidikan, umur, dan jenis pekerjaan. Metode: Metode penelitian yang digunakan dalam penelitian ini adalah penelitian bersifat deskriptif. Penelitian ini menggunakan penelitian cross sectional yaitu suatu penelitian dimana subjek diobsevasi hanya satu kali saja dan pengukurannya masing-masing satu variabel pada waktu yang sama yang menggunakan teknik sampling consecutive sampling. Sampel yang digunakan berjumlah 32 orang terdiri dari anggota keluarga pasien Halusinasi. Hasil: Berdasarkan penelitian yang dilakukan di Poliklinik Jiwa UPTD. Rumah Sakit Jiwa Provinsi Bali terhadap 32 anggota keluarga yang merawat pasien dengan skizofrenia, sebagian besar anggota keluarga tidak mengalami kecemasan atau kecemasan masih dalam batas normal jumlah 29 anggota keluarga dari 32 anggota keluarga dan 3 keluarga yang mengalami tingkat kecemasan ringan. Kesimpulan: Sebagian besar anggota keluarga yang merawat pasien dengan skizofrenia di Poliklinik Jiwa UPTD. Rumah Sakit Jiwa Provinsi Bali tidak mengalami kecemasan atau kecemasan masih dalam batas normal.

scholarly journals Piezo1 mediates angiogenesis through activation of MT1-MMP signaling

2019 ◽  
Vol 316 (1) ◽  
pp. C92-C103 ◽  
Author(s):  
Hojin Kang ◽  
Zhigang Hong ◽  
Ming Zhong ◽  
Jennifer Klomp ◽  
Kayla J. Bayless ◽  
...  
Keyword(s):  
Shear Stress ◽  
Wall Shear Stress ◽  
Matrix Metalloproteinase ◽  
Matrix Metalloproteinase 2 ◽  
Sprouting Angiogenesis ◽  
Sphingosine 1 Phosphate ◽  
Wall Shear ◽  
Membrane Type

Angiogenesis is initiated in response to a variety of external cues, including mechanical and biochemical stimuli; however, the underlying signaling mechanisms remain unclear. Here, we investigated the proangiogenic role of the endothelial mechanosensor Piezo1. Genetic deletion and pharmacological inhibition of Piezo1 reduced endothelial sprouting and lumen formation induced by wall shear stress and proangiogenic mediator sphingosine 1-phosphate, whereas Piezo1 activation by selective Piezo1 activator Yoda1 enhanced sprouting angiogenesis. Similarly to wall shear stress, sphingosine 1-phosphate functioned by activating the Ca2+ gating function of Piezo1, which in turn signaled the activation of the matrix metalloproteinase-2 and membrane type 1 matrix metalloproteinase during sprouting angiogenesis. Studies in mice in which Piezo1 was conditionally deleted in endothelial cells demonstrated the requisite role of sphingosine 1-phosphate-dependent activation of Piezo1 in mediating angiogenesis in vivo. These results taken together suggest that both mechanical and biochemical stimuli trigger Piezo1-mediated Ca2+ influx and thereby activate matrix metalloproteinase-2 and membrane type 1 matrix metalloproteinase and synergistically facilitate sprouting angiogenesis.

scholarly journals Role of Matrix Metalloproteinase-2 in Eosinophil-Mediated Airway Remodeling

2018 ◽  
Vol 9 ◽  
Author(s):  
Yu Kuwabara ◽  
Tetsu Kobayashi ◽  
Corina N. D'Alessandro-Gabazza ◽  
Masaaki Toda ◽  
Taro Yasuma ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Airway Remodeling ◽  
Matrix Metalloproteinase 2

scholarly journals Hubungan Spiritualitas dengan Stres pada Penderita Hipertensi di Poli Jantung RSU dr. H. Koesnadi-Bondowoso

2019 ◽  
Vol 7 (2) ◽  
pp. 88
Author(s):  
Muhamad Alfian Adyatma ◽  
Murtaqib Murtaqib ◽  
Baskoro Setioputro
Keyword(s):  
Perceived Stress ◽  
Sampling Technique ◽  
Life Goals ◽  
P Value ◽  
Spearman Correlation ◽  
Cross Sectional ◽  
Stress Scale ◽  
Consecutive Sampling ◽  
Spearman Correlation Test ◽  
Daily Spiritual Experience Scale

Stress becomes one of the factors causing hypertension. The correlation of stress and hypertension occurs through sympathetic nerve activities, which can gradually increase blood pressure. Spirituality is one of coping to deal with stress. Someone who has a high spiritual level is believed that his belief and relationship with God are better. This study analyzed the correlation between spirituality and stress in hypertension patients at the Cardiology unit of dr. H. Koesnadi Hospital-Bondowoso. The variables were Spirituality and Stress. The research design was observational analytic with a cross-sectional approach with 84 respondents obtained using consecutive sampling technique. The data collection was carried out by giving the Daily Spiritual Experience Scale (DSES) and Perceived Stress Scale (PSS) questionnaire on August 14th-28th 2018. The results of analysis using the Spearman correlation test were p value = 0.001 and r = -0,429 (p <0, 05), indicated a significant correlation between spirituality and stress in hypertension patients. A person who has good spirituality can control his chronic disease and help him to manage his conditions patiently, calmly and can determine his life goals. Suggestions for nurses are to be able to provide motivation to patients to accept the disease and improve adherence to the treatment.      

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