Pregnancy outcome, once viability is ascertained, is not associated with endometrial thickness on day of hCG in patients with polycystic ovarian syndrome (PCOS) or other infertility diagnoses undergoing controlled ovarian hyperstimulation (COH)

2002 ◽  
Vol 78 ◽  
pp. S155
Author(s):  
Seth Feigenbaum ◽  
Liberato Mukul ◽  
Sekou Kelsey ◽  
Nydia Lovell ◽  
Nancy Zinn ◽  
...  
Keyword(s):  
Pregnancy Outcome ◽  
Polycystic Ovarian Syndrome ◽  
Endometrial Thickness ◽  
Controlled Ovarian Hyperstimulation ◽  
Ovarian Hyperstimulation ◽  
Ovarian Syndrome

scholarly journals Changes in Coagulation and Fibrinolytic Indices in Women with Polycystic Ovarian Syndrome Undergoing Controlled Ovarian Hyperstimulation

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Ying Huang ◽  
Yong Zhao ◽  
Ling Yan ◽  
Yun-Hai Chuai ◽  
Ling-Ling Liu ◽  
...  
Keyword(s):  
Polycystic Ovarian Syndrome ◽  
Controlled Ovarian Hyperstimulation ◽  
Endocrine Function ◽  
Control Group ◽  
Ovarian Hyperstimulation ◽  
Vitro Fertilization ◽  
The Status ◽  
Pcos Group ◽  
Ovarian Syndrome

Background. Polycystic ovarian syndrome (PCOS) women undergoing in vitro fertilization and embryo transfer (IVF-ET) treatment always attain a low cumulative pregnancy rate disaccording with the satisfactory number of oocytes.Objective. We aim to evaluate the status of coagulation and fibrinolytic system in PCOS patients undergoing controlled ovarian hyperstimulation (COH) process.Method. Of the 97 women, 30 patients with PCOS composed the study group; 67 women of child-bearing age with normal endocrine function composed the control group. All participants underwent GnRH agonist standard long protocol, and plasma HCY, FVIII, FX, and D-dimer levels as well as hormone parameters were measured at day of full downregulation, hCG priming, and embryos transfer.Results. On day of full downregulation, FX levels were significantly higher in PCOS group (P<0.01). On hCG priming day, FX and estrogen levels in PCOS group were higher than in the control group and FVIII levels were significantly lower on day of embryos transfer whereas FX and E2 levels were significantly higher in PCOS group.Conclusion. Hypercoagulable state during peri-implantation phase would probably lead to poor microcirculation of endometrium and be one of the most important disadvantages of successful implantation and subsequent clinical pregnancy.

scholarly journals Effect of gonadotropins and endometrial thickness on pregnancy outcome in patients with unexplained infertility or polycystic ovarian syndrome undergoing intrauterine insemination

2020 ◽  
Vol 48 (10) ◽  
pp. 030006052096653
Author(s):  
Qing Li ◽  
Maoling Zhu ◽  
Zhuxiu Deng ◽  
Lihua Wang ◽  
Yi Huang ◽  
...  
Keyword(s):  
Pregnancy Rate ◽  
Pregnancy Outcome ◽  
Polycystic Ovarian Syndrome ◽  
Endometrial Thickness ◽  
Intrauterine Insemination ◽  
Unexplained Infertility ◽  
Clinical Pregnancy ◽  
Clinical Pregnancy Rates ◽  
Ovarian Syndrome ◽  
Endometrial Proliferation

Objective The purpose of this study was to investigate the effect of gonadotropin dose and endometrial thickness (EMT) on pregnancy outcome in patients undergoing intrauterine insemination (IUI). Methods We retrospectively analyzed data from 361 patients with unexplained infertility or polycystic ovarian syndrome (PCOS) who underwent 930 IUI cycles treated with gonadotropins. Then, we measured the effects of gonadotropins and EMT on the clinical pregnancy rate. Finally, we assessed the association of various doses of gonadotropins on EMT. Results The dose of gonadotropins given and thickness of the endometrium were higher in the pregnancy group than in the nonpregnancy group (636.0 vs. 600.0 IU for gonadotropin dose; 9.15 vs. 8.70 mm for EMT). Clinical pregnancy rates were significantly improved by increasing the dose of gonadotropins (9.1%, <450 IU; 16.2%, 450–599 IU; 18.6%, 600–749 IU, and 17.3%, ≥750 IU), or by increased EMT (0%, <5.0 mm; 12.2%, 5.0–6.9 mm; 15.5%, 7.0–14.0 mm; and 33.3%, >14.0 mm). Conclusion Increasing the dose of gonadotropins to stimulate one follicle to develop may benefit endometrial proliferation and improve IUI outcomes.

scholarly journals Role of Serum miRNAs in the Prediction of Ovarian Hyperstimulation Syndrome in Polycystic Ovarian Syndrome Patients

2015 ◽  
Vol 35 (3) ◽  
pp. 1086-1094 ◽  
Author(s):  
Chun Zhao ◽  
Xiaoguang Liu ◽  
Zhonghua Shi ◽  
Jing Zhang ◽  
Junqiang Zhang ◽  
...  
Keyword(s):  
Ovarian Hyperstimulation Syndrome ◽  
Polycystic Ovarian Syndrome ◽  
Positive Association ◽  
Controlled Ovarian Hyperstimulation ◽  
Ovarian Hyperstimulation ◽  
Altered Expression ◽  
Serum Mirnas ◽  
Increased Risk ◽  
Ovarian Syndrome ◽  
Severe Ohss

Background: Polycystic ovarian syndrome (PCOS) causes a significantly increased risk of ovarian hyperstimulation syndrome (OHSS). Here, we focused on the altered expression of serum miRNAs and their predictive value for OHSS in PCOS patients. Methods: We used the TaqMan low density array followed by individual quantitative reverse transcription-polymerase chain reaction to identify and validate the expression of serum miRNAs in PCOS patients likely to develop severe OHSS. Results: The miR-16 and miR-223 expression levels were significantly reduced in the patients who were likely to develop severe OHSS than in the control subjects who were likely to develop mild or no OHSS. The sensitivity and specificity of the basal LH, basal LH/FSH, and body mass index (BMI) as OHSS predictors were also evaluated. miR-16 was the most efficient for OHSS prediction as it yielded the highest AUC. Logistic binary regression analyses revealed a positive association of miR-223 and BMI. Conclusion: Serum miRNAs are differentially expressed in PCOS patients likely to suffer from severe OHSS. We identified and validated two serum miRNAs that have potential for use as novel noninvasive biomarkers to accurately predict OHSS before controlled ovarian hyperstimulation (COH) for PCOS patients.

Sign in / Sign up

Export Citation Format

Share Document