S1153 Preoperative Infliximab and Risk of Postoperative Complications in Patients with Inflammatory Bowel Disease: Meta-Analysis of Observational Studies

2009 ◽  
Vol 136 (5) ◽  
pp. A-201
Author(s):  
Venkataraman Subramanian ◽  
Chris J. Hawkey
Keyword(s):  
Inflammatory Bowel Disease ◽  
Postoperative Complications ◽  
Bowel Disease ◽  
Observational Studies ◽  
Meta Analysis ◽  
Inflammatory Bowel

scholarly journals Sarcopenia as an independent predictor of the surgical outcomes of patients with inflammatory bowel disease: a meta-analysis

Surgery Today ◽  
2019 ◽  
Vol 50 (10) ◽  
pp. 1138-1150 ◽  
Author(s):  
Adrienn Erős ◽  
Alexandra Soós ◽  
Péter Hegyi ◽  
Zsolt Szakács ◽  
Márton Benke ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Postoperative Complications ◽  
Early Detection ◽  
Confidence Interval ◽  
Bowel Disease ◽  
Surgical Outcomes ◽  
Independent Predictor ◽  
Meta Analysis ◽  
Random Effects Models ◽  
Inflammatory Bowel

Abstract Patients with inflammatory bowel disease (IBD) are at risk of sarcopenia, which is associated with poor clinical outcomes. We conducted this study to assess whether sarcopenia predicts the need for surgery and postoperative complications in patients with IBD. We performed a systematic search of four electronic databases, last updated in March, 2019. Data from studies comparing rates of surgery and postoperative complications in sarcopenic IBD patients versus non-sarcopenic IBD patients were pooled with the random-effects models. We calculated the odds ratios (OR) with a 95% confidence interval (CI). Ten studies with a collective total of 885 IBD patients were included in our meta-analysis. Although the analysis of raw data did not reveal significant differences between the two groups with respect to the rate of surgery and postoperative complications (OR = 1.826; 95% CI 0.913–3.654; p = 0.089 and OR = 3.265; 95% CI 0.575–18.557; p = 0.182, respectively), the analysis of adjusted data identified sarcopenia as an independent predictor for both of the undesirable outcomes (OR = 2.655; 95% CI 1.121–6.336; p = 0.027 and OR = 6.097; 95% CI 1.756–21.175; p = 0.004, respectively). Thus, early detection of sarcopenia in patients with IBD is important to prevent undesirable outcomes.

Systematic Review and Meta-analysis: Vedolizumab and Postoperative Complications in Inflammatory Bowel Disease

2018 ◽  
Vol 24 (11) ◽  
pp. 2327-2338 ◽  
Author(s):  
Diana E Yung ◽  
Nir Horesh ◽  
Amy L Lightner ◽  
Shomron Ben-Horin ◽  
Rami Eliakim ◽  
...  
Keyword(s):  
Systematic Review ◽  
Inflammatory Bowel Disease ◽  
Postoperative Complications ◽  
Bowel Disease ◽  
Meta Analysis ◽  
Inflammatory Bowel

Systematic Review and Meta-Analysis: Preoperative Vedolizumab Treatment and Postoperative Complications in Patients with Inflammatory Bowel Disease

2018 ◽  
Vol 12 (5) ◽  
pp. 538-545 ◽  
Author(s):  
Cindy C Y Law ◽  
Alisha Narula ◽  
Amy L Lightner ◽  
Nicholas P McKenna ◽  
Jean-Frederic Colombel ◽  
...  
Keyword(s):  
Systematic Review ◽  
Inflammatory Bowel Disease ◽  
Postoperative Complications ◽  
Bowel Disease ◽  
Meta Analysis ◽  
Inflammatory Bowel

scholarly journals Association betweenFaecalibacterium prausnitziiReduction and Inflammatory Bowel Disease: A Meta-Analysis and Systematic Review of the Literature

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Yuan Cao ◽  
Jun Shen ◽  
Zhi Hua Ran
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Observational Studies ◽  
Meta Analysis ◽  
Laboratory Data ◽  
Bacterial Count ◽  
Healthy Controls ◽  
Inclusion Criteria ◽  
Inflammatory Bowel ◽  
Review Manager

Background. Laboratory data suggests a reduction ofFaecalibacterium prausnitzii(F. prausnitzii) is confirmed both in fecal samples in inflammatory bowel disease (IBD) patients. Numerous observational studies have suspected dysbiosis, an imbalance between protective and harmful bacteria to be relevant to the etiology and pathogenesis of IBD.Methods. Medline, EMBASE, Pubmed, and others. were searched by 2 independent reviewers. Of 48 abstracts reviewed, 11 studies met our inclusion criteria (subjectN=1180). Meta-analysis was performed with Review Manager 5.2.Results. The bacterial count ofF. prausnitziiin IBD patients was significantly lower (6.7888±1.8875) log10 CFU/g feces than healthy controls (7.5791±1.5812) log10 CFU/g feces;P<0.0001. The Standardization Mean Difference ofF. prausnitziiin IBD patients was −0.94 (95% confidence interval [CI]: −1.07–−0.80). Subgroup analyses revealed a trend toward a greater effect for CD (SMD: −1.13, 95% CI: −1.32–−0.94) when compared to UC (SMD: −0.78, 95% CI: −0.97–−0.60).Conclusions. The abundance ofF. prausnitziiwas decreased in IBD patients compared with healthy controls. Furthermore, the reduction ofF. prausnitziiand misbalance of the intestinal microbiota are particularly higher in CD patients with ileal involvement.

Association between Thiopurines Use and Pregnancy Outcomes in Female Patients with Inflammatory Bowel Disease: A Meta-analysis

2020 ◽  
Vol 26 ◽  
Author(s):  
Yang Zhang ◽  
Dandan Li ◽  
Heng Guo ◽  
Weina Wang ◽  
Xingang Li ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Preterm Birth ◽  
Spontaneous Abortion ◽  
Bowel Disease ◽  
Pregnancy Outcomes ◽  
Congenital Malformations ◽  
Meta Analysis ◽  
Adverse Pregnancy Outcomes ◽  
Inflammatory Bowel ◽  
Adverse Pregnancy

Background: Conflicting data exist regarding the influence of thiopurines exposure on adverse pregnancy outcomes in female patients with inflammatory bowel disease (IBD). Objective: The aim of this study was to provide an up-to-date and comprehensive assessment of the safety of thiopurines in pregnant IBD women. Methods: All relevant articles reporting pregnancy outcomes in women with IBD received thiopurines during pregnancy were identified from the databases (PubMed, Embase, Cochrane Library, and ClinicalTrials.gov) with the publication data up to April 2020. Data of included studies were extracted to calculate the relative risk (RR) of multiple pregnancy outcomes: congenital malformations, low birth weight (LBW), preterm birth, small for gestational age (SGA), and spontaneous abortion. The meta-analysis was performed using the random-effects model. Results: Eight studies matched with the inclusion criteria and a total of 1201 pregnant IBD women who used thiopurines and 4189 controls comprised of women with IBD received drugs other than thiopurines during pregnancy were included. Statistical analysis results demonstrated that the risk of preterm birth was significantly increased in the thiopurine-exposed group when compared to IBD controls (RR, 1.34; 95% CI, 1.00-1.79; p=0.049; I 2 =41%), while no statistically significant difference was observed in the incidence of other adverse pregnancy outcomes. Conclusion: Thiopurines’ use in women with IBD during pregnancy is not associated with congenital malformations, LBW, SGA, or spontaneous abortion, but appears to have an association with an increased risk of preterm birth.

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