Natalizumab Use in Patients With Crohn's Disease and Relapsing Multiple Sclerosis: Updated Utilization and Safety Results From the Touch® Prescribing Program, the Pregnancy Registry, and the Inform and TYGRIS Studies

2011 ◽  
Vol 140 (5) ◽  
pp. S-275
Author(s):  
Anthony M. Pepio ◽  
Lori Taylor ◽  
Gary S. Hogge ◽  
Gary Bloomgren ◽  
Lynda M. Cristiano ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Relapsing Multiple Sclerosis ◽  
Pregnancy Registry

Natalizumab use in patients with Crohn's disease and relapsing multiple sclerosis

2011 ◽  
Vol 17 (suppl_1) ◽  
pp. S56-S57
Author(s):  
A Pepio ◽  
L Taylor ◽  
M Kooijmans ◽  
L Cristiano ◽  
C Bozic ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Relapsing Multiple Sclerosis

Avoiding infliximab in the treatment of Crohn's disease in patients with multiple sclerosis

2003 ◽  
Vol 98 (10) ◽  
pp. 2333-2334 ◽  
Author(s):  
Shardul A. Nanavati ◽  
Gulchin A. Ergun ◽  
Jim T. Schwartz
Keyword(s):  
Multiple Sclerosis ◽  
Crohn’S Disease ◽  
Crohn's Disease

Similar birth-cohort patterns in Crohn’s disease and multiple sclerosis

2017 ◽  
Vol 24 (2) ◽  
pp. 140-149 ◽  
Author(s):  
Amnon Sonnenberg ◽  
Vladeta Ajdacic-Gross
Keyword(s):  
Risk Factors ◽  
Multiple Sclerosis ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Birth Cohort ◽  
Environmental Risk ◽  
Time Trends ◽  
The United States ◽  
Environmental Risk Factors

Background: The etiology of Crohn’s disease and multiple sclerosis is unknown. Genetic susceptibility and environmental factors are believed to play a role in both diseases. Objectives: To compare the long-term time trends of the two diseases and thus gain insight about their etiology. Methods: We analyzed mortality data of Crohn’s disease and multiple sclerosis from Canada, England, Italy, the Netherlands, Switzerland, and the United States during the past 60 years. Age–period–cohort (APC) analyses based on logit models served to disentangle the separate influences of age, period, and cohort effects on the overall time trends. Results: The long-term time trends of Crohn’s disease and multiple sclerosis have been shaped by strikingly similar birth-cohort patterns. In both diseases alike, mortality increased in all generations born prior to 1910. It peaked among generations born between 1910 and 1930 and then declined in all subsequent generations. Similar birth-cohort patterns of Crohn’s disease and multiple sclerosis were found in each country analyzed separately. Conclusion: The birth-cohort patterns indicate that the development of Crohn’s disease and multiple sclerosis is influenced by exposure to environmental risk factors during an early period of life. These environmental risk factors may be similar or even identical in Crohn’s disease and multiple sclerosis.

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