Avoiding infliximab in the treatment of Crohn's disease in patients with multiple sclerosis

2003 ◽  
Vol 98 (10) ◽  
pp. 2333-2334 ◽  
Author(s):  
Shardul A. Nanavati ◽  
Gulchin A. Ergun ◽  
Jim T. Schwartz
Keyword(s):  
Multiple Sclerosis ◽  
Crohn’S Disease ◽  
Crohn's Disease

Similar birth-cohort patterns in Crohn’s disease and multiple sclerosis

2017 ◽  
Vol 24 (2) ◽  
pp. 140-149 ◽  
Author(s):  
Amnon Sonnenberg ◽  
Vladeta Ajdacic-Gross
Keyword(s):  
Risk Factors ◽  
Multiple Sclerosis ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Birth Cohort ◽  
Environmental Risk ◽  
Time Trends ◽  
The United States ◽  
Environmental Risk Factors

Background: The etiology of Crohn’s disease and multiple sclerosis is unknown. Genetic susceptibility and environmental factors are believed to play a role in both diseases. Objectives: To compare the long-term time trends of the two diseases and thus gain insight about their etiology. Methods: We analyzed mortality data of Crohn’s disease and multiple sclerosis from Canada, England, Italy, the Netherlands, Switzerland, and the United States during the past 60 years. Age–period–cohort (APC) analyses based on logit models served to disentangle the separate influences of age, period, and cohort effects on the overall time trends. Results: The long-term time trends of Crohn’s disease and multiple sclerosis have been shaped by strikingly similar birth-cohort patterns. In both diseases alike, mortality increased in all generations born prior to 1910. It peaked among generations born between 1910 and 1930 and then declined in all subsequent generations. Similar birth-cohort patterns of Crohn’s disease and multiple sclerosis were found in each country analyzed separately. Conclusion: The birth-cohort patterns indicate that the development of Crohn’s disease and multiple sclerosis is influenced by exposure to environmental risk factors during an early period of life. These environmental risk factors may be similar or even identical in Crohn’s disease and multiple sclerosis.

scholarly journals Correction: CD40: Novel Association with Crohn's Disease and Replication in Multiple Sclerosis Susceptibility

PLoS ONE ◽  
2010 ◽  
Vol 5 (8) ◽  
Author(s):  
Fiona Blanco-Kelly ◽  
Fuencisla Matesanz ◽  
Antonio Alcina ◽  
María Teruel ◽  
Lina M. Díaz-Gallo ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Multiple Sclerosis Susceptibility ◽  
Novel Association

scholarly journals CD40: Novel Association with Crohn's Disease and Replication in Multiple Sclerosis Susceptibility

PLoS ONE ◽  
2010 ◽  
Vol 5 (7) ◽  
pp. e11520 ◽  
Author(s):  
Fiona Blanco-Kelly ◽  
Fuencisla Matesanz ◽  
Antonio Alcina ◽  
María Teruel ◽  
Lina M. Díaz-Gallo ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Multiple Sclerosis Susceptibility ◽  
Novel Association

scholarly journals Crohn's disease and multiple sclerosis: A single case report

1994 ◽  
Vol 15 (6) ◽  
pp. 303-306 ◽  
Author(s):  
G. P. Buccino ◽  
G. Corrente ◽  
D. Visintini
Keyword(s):  
Multiple Sclerosis ◽  
Crohn’S Disease ◽  
Case Report ◽  
Crohn's Disease ◽  
Single Case ◽  
Single Case Report

The zoonotic potential ofMycobacterium aviumssp.paratuberculosis: a systematic review and meta-analyses of the evidence

2015 ◽  
Vol 143 (15) ◽  
pp. 3135-3157 ◽  
Author(s):  
L. A. WADDELL ◽  
A. RAJIĆ ◽  
K. D. C. STÄRK ◽  
S. A. McEWEN
Keyword(s):  
Multiple Sclerosis ◽  
Systematic Review ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Significant Proportion ◽  
Positive Association ◽  
Detection Methods ◽  
Zoonotic Potential ◽  
Sampling Frame ◽  
Significant Positive Association

SUMMARYThis systematic review–meta-analysis appraises and summarizes all the available research (128 papers) on the zoonotic potential ofMycobacterium aviumssp.paratuberculosis.The latter has been debated for a century due to pathogenic and clinical similarities between Johne's disease in ruminants and Crohn's disease (108 studies) in humans and recently for involvement in other human diseases; human immunodeficiency virus (HIV) infection (2), sarcoidosis (3), diabetes mellitus type 1 (T1DM) (7) and type 2 (3), multiple sclerosis (5) and Hashimoto's thyroiditis (2). Meta-analytical results indicated a significant positive association, consistently across different laboratory methods for Crohn's disease [odds ratio (OR) range 4·26–8·44], T1DM (OR range 2·91–9·95) and multiple sclerosis (OR range 6·5–7·99). The latter two and the thyroiditis hypothesis require further investigation to confirm the association. Meta-regression of Crohn's disease studies using DNA detection methods indicated that choice of primers and sampling frame (e.g. general populationvs. hospital-based sample) explained a significant proportion of heterogeneity. Other epidemiological studies demonstrated a lack of association between high-risk occupations and development of Crohn's disease. Due to knowledge gaps in understanding the role ofM. paratuberculosisin the development or progression of human disease, the evidence at present is not strong enough to inform the potential public health impact ofM. paratuberculosisexposure.

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