558 The Therapeutic Potential of Rat Umbilical Mesenchymal Stem Cells From Wharton's Jelly in the Treatment of Rat Chronic Pancreatitis and Subsequent Pancreatic Fibrosis Induced by DBTC

2012 ◽  
Vol 142 (5) ◽  
pp. S-112-S-113
Author(s):  
Wang Shaofeng ◽  
Zhou Chunhua ◽  
Qin Ailan
2009 ◽  
Vol 15 (5) ◽  
pp. 484-495 ◽  
Author(s):  
Pei-Chun Tsai ◽  
Tz-Win Fu ◽  
Yi-Ming Arthur Chen ◽  
Tsui-Ling Ko ◽  
Tien-Hua Chen ◽  
...  

Author(s):  
Malgorzata Witkowska-Zimny ◽  
Edyta Wrobel

AbstractRecently, stem cell biology has become an interesting topic, especially in the context of treating diseases and injuries using transplantation therapy. Several varieties of human stem cells have been isolated and identified in vivo and in vitro. Ideally, stem cells for regenerative medical application should be found in abundant quantities, harvestable in a minimally invasive procedure, then safely and effectively transplanted to either an autologous or allogenic host. The two main groups of stem cells, embryonic stem cells and adult stem cells, have been expanded to include perinatal stem cells. Mesenchymal stem cells from perinatal tissue may be particularly useful in the clinic for autologous transplantation for fetuses and newborns, and after banking in later stages of life, as well as for in utero transplantation in case of genetic disorders.This review highlights the characteristics and therapeutic potential of three human mesenchymal stem cell types obtained from perinatal sources: Wharton’s jelly, the amnion, and the chorion.


Theranostics ◽  
2019 ◽  
Vol 9 (22) ◽  
pp. 6646-6664 ◽  
Author(s):  
Kuo-An Chu ◽  
Shih-Yao Wang ◽  
Chang-Ching Yeh ◽  
Tz-Win Fu ◽  
Yu-Yi Fu ◽  
...  

2021 ◽  
Vol 22 (2) ◽  
pp. 845
Author(s):  
Sungho Shin ◽  
Jeongmin Lee ◽  
Yumi Kwon ◽  
Kang-Sik Park ◽  
Jae-Hoon Jeong ◽  
...  

Mesenchymal stem cells (MSCs) have the potential to be a viable therapy against various diseases due to their paracrine effects, such as secretion of immunomodulatory, trophic and protective factors. These cells are known to be distributed within various organs and tissues. Although they possess the same characteristics, MSCs from different sources are believed to have different secretion potentials and patterns, which may influence their therapeutic effects in disease environments. We characterized the protein secretome of adipose (AD), bone marrow (BM), placenta (PL), and Wharton’s jelly (WJ)-derived human MSCs by using conditioned media and analyzing the secretome by mass spectrometry and follow-up bioinformatics. Each MSC secretome profile had distinct characteristics depending on the source. However, the functional analyses of the secretome from different sources showed that they share similar characteristics, such as cell migration and negative regulation of programmed cell death, even though differences in the composition of the secretome exist. This study shows that the secretome of fetal-derived MSCs, such as PL and WJ, had a more diverse composition than that of AD and BM-derived MSCs, and it was assumed that their therapeutic potential was greater because of these properties.


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