Sa1122 Impact of Infliximab on Short-Term Postoperative Outcomes in Patients With Crohn's Disease Undergoing Ileocolic Resection

2015 ◽  
Vol 148 (4) ◽  
pp. S-232
Author(s):  
Azah Althumairi ◽  
Jonathan E. Efron ◽  
Brindusa Truta ◽  
Joseph K. Canner ◽  
Susan Gearhart ◽  
...  
2006 ◽  
Vol 23 (5-6) ◽  
pp. 346-357 ◽  
Author(s):  
Sebastiaan W. Polle ◽  
Jan Wind ◽  
Dirk T. Ubbink ◽  
Daan W. Hommes ◽  
Dirk J. Gouma ◽  
...  

2009 ◽  
Vol 23 (8) ◽  
pp. 1876-1881 ◽  
Author(s):  
Mattias Soop ◽  
David W. Larson ◽  
Kishore Malireddy ◽  
Robert R. Cima ◽  
Tonia M. Young-Fadok ◽  
...  

2009 ◽  
Vol 12 (10Online) ◽  
pp. e298-e303 ◽  
Author(s):  
S. Riss ◽  
C. Bittermann ◽  
S. Zandl ◽  
I. Kristo ◽  
A. Stift ◽  
...  

2018 ◽  
Vol 108 (1) ◽  
pp. 42-48 ◽  
Author(s):  
V. Celentano ◽  
F. Sagias ◽  
K. G. Flashman ◽  
J. Conti ◽  
J. Khan

Purposes: Over 80% of patients with primary ileocolic Crohn’s disease have a surgical resection within 10 years of diagnosis, and 40%–50% of them need further surgery within 15 years. Laparoscopic surgery can be challenging due to a thickened mesentery and the potential for fistulas, abscesses, and phlegmons. Aim of this study is to analyze the short-term outcomes of laparoscopic redo ileocolic resections for Crohn’s disease in patients with previous multiple laparotomies. Methods: All patients undergoing laparoscopic surgery for ileocolic Crohn’s disease from March 2006 to February 2017 were prospectively evaluated. Short term outcomes of laparoscopic ileocolic resection were compared between patients with previous multiple major surgeries and recurrent Crohn’s disease, and patients undergoing surgery for the first presentation of Crohn’s disease and no history of previous surgery. Conversion rate and 30-day morbidity were the primary outcomes. Reoperations, readmissions, operating time and length of stay were the secondary outcomes. Results: 29 patients with recurrent Crohn’s disease and previous multiple laparotomies were included: the number of laparotomies these patients previously underwent was 2 in 19 cases (65.5%), 3 in 9 (31%), and 4 in 1 (3.5%). In total, 90 patients with no history of any previous abdominal surgery, who underwent laparoscopic ileocecal resection for Crohn’s disease, represented the control group. No differences were found in morbidity and conversion rate. Operating time was longer in patients with history of previous abdominal surgery. Conclusion: Laparoscopic redo ileocolic resection for Crohn’s disease is feasible and safe in patients with previous multiple laparotomies at the expense of longer operating time.


2020 ◽  
Author(s):  
Benichou Benjamin ◽  
Rahili Mohamed Amine ◽  
Bernard Jean Louis ◽  
Hébuterne Xavier ◽  
Schneider Stéphane ◽  
...  

Author(s):  
Giacomo Calini ◽  
Solafah Abdalla ◽  
Mohamed A. Abd El Aziz ◽  
Hamedelneel A. Saeed ◽  
Anne-Lise D. D’Angelo ◽  
...  

2019 ◽  
Vol 26 (7) ◽  
pp. 1050-1058 ◽  
Author(s):  
Robert P Hirten ◽  
Ryan C Ungaro ◽  
Daniel Castaneda ◽  
Sarah Lopatin ◽  
Bruce E Sands ◽  
...  

Abstract Background Crohn’s disease recurrence after ileocolic resection is common and graded with the Rutgeerts score. There is controversy whether anastomotic ulcers represent disease recurrence and should be included in the grading system. The aim of this study was to determine the impact of anastomotic ulcers on Crohn’s disease recurrence in patients with prior ileocolic resections. Secondary aims included defining the prevalence of anastomotic ulcers, risk factors for development, and their natural history. Methods We conducted a retrospective cohort study of patients undergoing an ileocolic resection between 2008 and 2017 at a large academic center, with a postoperative colonoscopy assessing the neoterminal ileum and ileocolic anastomosis. The primary outcome was disease recurrence defined as endoscopic recurrence (>5 ulcers in the neoterminal ileum) or need for another ileocolic resection among patients with or without an anastomotic ulcer in endoscopic remission. Results One hundred eighty-two subjects with Crohn’s disease and an ileocolic resection were included. Anastomotic ulcers were present in 95 (52.2%) subjects. No factors were associated with anastomotic ulcer development. One hundred eleven patients were in endoscopic remission on the first postoperative colonoscopy. On multivariable analysis, anastomotic ulcers were associated with disease recurrence (adjusted hazard ratio [aHR] 3.64; 95% CI, 1.21–10.95; P = 0.02). Sixty-six subjects with anastomotic ulcers underwent a second colonoscopy, with 31 patients (79.5%) having persistent ulcers independent of medication escalation. Conclusion Anastomotic ulcers occur in over half of Crohn’s disease patients after ileocolic resection. No factors are associated with their development. They are associated with Crohn’s disease recurrence and are persistent.


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