Tu1093 Enteral Nutrition Therapy for the Induction of Crohn's Disease in the Pediatric Population: A Systematic Review and Meta-Analysis

Inflammatory bowel disease (IBD) is a chronic disease mediated by the immune system and is characterized by inflammation of the gastrointestinal tract. One of the possible treatments for this pathology is a change in the type of diet, of which enteral nutrition (EN) is one. This study is to understand how the use of EN can affect the adult population diagnosed with IBD. We conducted a systematic review, meta-analysis, and a meta-regression. On the different databases (MEDLINE, Scopus, Cochrane, LILACS, CINAHL, WOS), we found 363 registers with an accuracy of 12% (44 registers). After a full-text review, only 30 research studies were selected for qualitative synthesis and 11 for meta-analysis and meta-regression. The variables used were Crohn’s disease activity index (CDAI), C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR). EN has been shown to have efficacy for the treatment of Crohn’s disease and is compatible with other medicines. As for the CDAI or rates of remission, there were no differences between enteral and parenteral nutrition. Polymeric formulas have shown better results with respect to the CRP. The long-term treatment could dilute the good CDAI results that are obtained at the start of the EN treatment.

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IDDF2019-ABS-0105 Systematic review with meta-analysis: partial enteral nutrition for maintenance of remission in crohn’s disease

10.1136/gutjnl-2019-iddfabstracts.148 ◽

2019 ◽

Author(s):

Hongsheng Yang ◽

Yun Qiu ◽

Rui Feng ◽

Shu Xu ◽

Xiuxue Hao ◽

...

Keyword(s):

Systematic Review ◽

Crohn’S Disease ◽

Crohn's Disease ◽

Enteral Nutrition ◽

Meta Analysis ◽

Maintenance Of Remission

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Specialized enteral nutrition therapy in Crohn’s disease patients on maintenance infliximab therapy: a meta-analysis

Therapeutic Advances in Gastroenterology ◽

10.1177/1756283x15578607 ◽

2015 ◽

Vol 8 (4) ◽

pp. 168-175 ◽

Cited By ~ 40

Author(s):

Douglas L. Nguyen ◽

Lena B. Palmer ◽

Emily T. Nguyen ◽

Stephen A. McClave ◽

Robert G. Martindale ◽

...

Keyword(s):

Crohn’S Disease ◽

Crohn's Disease ◽

Enteral Nutrition ◽

Meta Analysis ◽

Nutrition Therapy ◽

Infliximab Therapy

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ORAL AND ENTERAL NUTRITION THERAPY IN INFLAMMATORY BOWEL DISEASES AMONG THE PEDIATRIC POPULATION: A LITERATURE REVIEW

Revista Paulista de Pediatria ◽

10.1590/1984-0462/2020/38/2019032 ◽

2020 ◽

Vol 38 ◽

Author(s):

Gabriela Neves de Souza ◽

Patrícia Ferrante Draghi ◽

Glauce Hiromi Yonamine

Keyword(s):

Crohn’S Disease ◽

Crohn's Disease ◽

Enteral Nutrition ◽

Latin American ◽

Inflammatory Bowel Diseases ◽

Pediatric Population ◽

Nutrition Therapy ◽

Exclusive Enteral Nutrition ◽

Bowel Diseases ◽

Inflammatory Bowel

ABSTRACT Objectives: To review the literature on oral and enteral nutrition therapy and investigate the evidence of its efficacy as a treatment, as well as in preventing relapses and reducing symptoms of inflammatory bowel diseases in the pediatric population. Data source: We performed a bibliographic search in the PubMed, Web of Science, and Latin American and Caribbean Health Sciences Literature (Literatura Latino-Americana e do Caribe em Ciências da Saúde - Lilacs) databases, using the keywords “inflammatory bowel disease,” “diet,” and “diet therapy” in English and Portuguese, with filters for pediatric studies published in the previous five years. Data summary: We selected 16 articles for this study, nine on exclusive and/or partial enteral nutrition and seven on modified oral diets, such as the specific carbohydrate diet (SCD) and the Crohn’s Disease exclusion diet (CDED). The studies found evaluated the anthropometric profile of patients and the inflammatory profile of diseases in children before and after the introduction of each specific nutrition therapy. All interventions presented positive changes in these parameters; however, the results were inconclusive regarding the efficacy of SCD and CDED in the treatment and prevention of relapses. Conclusions: Exclusive enteral nutrition has proven to be effective in inducing remission of Crohn’s Disease, and the use of partial enteral nutrition for maintenance treatment has shown promising results. Other modified oral diets are inconclusive concerning their effectiveness, requiring further randomized controlled clinical trials.

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