Bovine skeletal growth factor stimulates protein phosphorylation of chicken bone cells in vitro

1988 ◽  
Vol 20 (12) ◽  
pp. 1443-1450 ◽  
Author(s):  
K.-H. William Lau ◽  
John C. Jennings ◽  
David J. Baylink
Keyword(s):  
Growth Factor ◽  
Protein Phosphorylation ◽  
Bone Cells ◽  
Skeletal Growth ◽  
Chicken Bone ◽  
Skeletal Growth Factor

Human skeletal growth factor: characterization of the mitogenic effect on bone cells in vitro

Biochemistry ◽  
1982 ◽  
Vol 21 (14) ◽  
pp. 3508-3513 ◽  
Author(s):  
John R. Farley ◽  
T. Masuda ◽  
J. E. Wergedal ◽  
David J. Baylink
Keyword(s):  
Growth Factor ◽  
Bone Cells ◽  
Skeletal Growth ◽  
Mitogenic Effect ◽  
Skeletal Growth Factor

Purification of a skeletal growth factor from human bone

Biochemistry ◽  
1982 ◽  
Vol 21 (14) ◽  
pp. 3502-3507 ◽  
Author(s):  
John R. Farley ◽  
David J. Baylink
Keyword(s):  
Growth Factor ◽  
Human Bone ◽  
Skeletal Growth ◽  
Skeletal Growth Factor

scholarly journals Increased serum and bone matrix levels of transforming growth factor β1 in patients with GH deficiency in response to GH treatment

2011 ◽  
Vol 165 (3) ◽  
pp. 393-400 ◽  
Author(s):  
Thor Ueland ◽  
Tove Lekva ◽  
Kari Otterdal ◽  
Tuva B Dahl ◽  
Nicoleta Cristina Olarescu ◽  
...  
Keyword(s):  
Growth Factor ◽  
Cortical Bone ◽  
Transforming Growth Factor ◽  
Bone Cells ◽  
Gh Deficiency ◽  
Bone Matrix ◽  
Transforming Growth Factor Β1 ◽  
Gh Treatment

ObjectivePatients with adult onset GH deficiency (aoGHD) have secondary osteoporosis, which is reversed by long-term GH substitution. Transforming growth factor β1 (TGFβ1 or TGFB1) is abundant in bone tissue and could mediate some effects of GH/IGFs on bone. We investigated its regulation by GH/IGF1in vivoandin vitro.Design and methodsThe effects of GH substitution (9–12 months, placebo controlled) on circulating and cortical bone matrix contents of TGFβ1 were investigated in patients with aoGHD. The effects of GH/IGF1 on TGFβ1 secretion in osteoblasts (hFOB), adipocytes, and THP-1 macrophages as well as the effects on release from platelets were investigatedin vitro.ResultsIn vivoGH substitution increased TGFβ1 protein levels in cortical bone and serum.In vitro, GH/IGF1 stimulation induced a significant increase in TGFβ1 secretion in hFOB. In contrast, no major effect of GH/IGF1 on TGFβ1 was found in adipocytes and THP-1 macrophages. Finally, a minor modifying effect on SFLLRN-stimulated platelet release of TGFβ1 was observed in the presence of IGF1.ConclusionGH substitution increases TGFβ1in vivoandin vitro, and this effect could contribute to improved bone metabolism during such therapy, potentially reflecting direct effect of GH/IGF1 on bone cells.

Human skeletal growth factor isolated

Science ◽  
1982 ◽  
Vol 217 (4562) ◽  
pp. 819-819 ◽  
Author(s):  
T. Maugh
Keyword(s):  
Growth Factor ◽  
Skeletal Growth ◽  
Skeletal Growth Factor

scholarly journals Role of the Latent Transforming Growth Factor β-Binding Protein 1 in Fibrillin-Containing Microfibrils in Bone Cells In Vitro and In Vivo

2000 ◽  
Vol 15 (1) ◽  
pp. 68-81 ◽  
Author(s):  
Sarah L. Dallas ◽  
Douglas R. Keene ◽  
Scott P. Bruder ◽  
Juha Saharinen ◽  
Lynn Y. Sakai ◽  
...  
Keyword(s):  
Growth Factor ◽  
Transforming Growth Factor ◽  
Bone Cells ◽  
Binding Protein ◽  
Transforming Growth Factor Β
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