Worm kinetics and serum IgE in Hooded Lister rats infected with the acanthocephalan Moniliformis moniliformis and the nematode Nippostrongylus brasiliensis

1996 ◽  
Vol 26 (11) ◽  
pp. 1287-1294 ◽  
Author(s):  
Ole Hindsbo ◽  
Per Aagåard Andersen ◽  
Peter Lind
Keyword(s):  
Nippostrongylus Brasiliensis ◽  
Serum Ige ◽  
Moniliformis Moniliformis

scholarly journals Research Note. Occurrence of gastrointestinal helminths in commensal rodents from Tabasco, Mexico

2017 ◽  
Vol 54 (2) ◽  
pp. 170-173 ◽  
Author(s):  
N. Cigarroa-Toledo ◽  
Y. De Los Santos-Martinez ◽  
C. V. Zaragoza-Vera ◽  
M. M. Garcia-Rodriguez ◽  
C. M. Baak-Baak ◽  
...  
Keyword(s):  
Rattus Rattus ◽  
Hymenolepis Diminuta ◽  
Nippostrongylus Brasiliensis ◽  
Gastrointestinal Helminths ◽  
Trichuris Muris ◽  
Heligmosomoides Polygyrus ◽  
Syphacia Muris ◽  
Commensal Rodents ◽  
Syphacia Obvelata ◽  
Moniliformis Moniliformis

Summary The aim of this study was to determine the prevalence and species composition of helminths in commensal rodents captured inside private residences in the city of Villahermosa in Tabasco, Mexico. Trapping was performed at each house for three consecutive nights from October to December 2015. Fifty commensal rodents were captured: 23 Rattus norvegicus, 16 Mus musculus and 11 Rattus rattus. Rodents were transported alive to the laboratory and held in cages until they defecated. Feces were analyzed for helminth eggs using the Sheather’s flotation technique. The overall prevalence of helminths in rodents was 60 %: R. norvegicus was more likely to be parasitized (87.0 %) than R. rattus (63.6 %) and M. musculus (18.8 %). Eggs from at least 13 species of helminths were identified: Hymenolepis diminuta, Rodentolepis nana, Moniliformis moniliformis, Heligmosomoides polygyrus, Heterakis spumosa, Mastophorus muris, Nippostrongylus brasiliensis, Strongyloides ratti, Syphacia obvelata, Syphacia muris, Toxocara sp., Trichosomoides crassicauda, and Trichuris muris. This is the first study to report the presence of H. polygyrus, S. ratti and T. crassicauda in commensal rodents in Mexico. In conclusion, our results suggest that helminths commonly infect commensal rodents in Villahermosa and therefore rodents present a health risk to inhabitants in this region.

Biotic and abiotic effects on the intestinal helminth community of the brown ratRattus norvegicusfrom Rio de Janeiro, Brazil

2014 ◽  
Vol 90 (1) ◽  
pp. 21-27 ◽  
Author(s):  
R.O. Simões ◽  
J.L. Luque ◽  
R. Gentile ◽  
M.C.S. Rosa ◽  
S. Costa-Neto ◽  
...  
Keyword(s):  
Community Structure ◽  
Rio De Janeiro ◽  
Abundant Species ◽  
Helminth Species ◽  
Intestinal Helminth ◽  
Nippostrongylus Brasiliensis ◽  
Helminth Community ◽  
Public Health Importance ◽  
Strongyloides Venezuelensis ◽  
Moniliformis Moniliformis

AbstractRattus norvegicushas attracted much attention because of its role as a reservoir of zoonotic pathogens. This work aimed to identify the intestinal helminth species inR. norvegicusand to analyse the effects of temperature, rainfall, host age and sex on the helminth community structure. Moreover, this study investigated the possible associations among helminth species in an urban population ofR. norvegicusin São Gonçalo, Rio de Janeiro, sampled during the rainy and dry seasons over a span of 2 years. A total of 112 rats were infected by six species of helminths. The nematodeNippostrongylus brasiliensiswas the most prevalent and abundant species, with high mean intensity in both seasons, followed byStrongyloides venezuelensis,Heterakis spumosa,Raillietinasp.,Hymenolepis nanaandMoniliformis moniliformis.Co-occurrence was found betweenN. brasiliensisandS. venezuelensisand betweenN. brasiliensisandH. spumosa.The occurrence ofS. venezuelensiswas related to rainfall. The understanding of the helminth community structure in this synanthropic rat provides basic information on parasites of public health importance, as two helminth species (H. nanaandM. moniliformis) recovered from rats in the urban area studied can infect humans.

Interspecific effects betweenMoniliformis(Acanthocephala),Hymenolepis(Cestoda) andNippostrongylus(Nematoda) in the laboratory rat

Parasitology ◽  
1987 ◽  
Vol 94 (3) ◽  
pp. 567-581 ◽  
Author(s):  
Celia Holland
Keyword(s):  
Dry Weight ◽  
Hymenolepis Diminuta ◽  
Single Infection ◽  
Nippostrongylus Brasiliensis ◽  
Laboratory Rat ◽  
Concurrent Infections ◽  
Parasite Infections ◽  
Moniliformis Moniliformis

Rats harbouring 35-day-old primary infections ofMoniliformis moniliformisandHymenolepis diminutawere inoculated with equal doses ofNippostrongylus brasiliensisand were autopsied 10 days later. Significant reductions were found in the dry weight ofMoniliformisandHymenolepisand in the numbers ofNippostrongylusrecovered compared with single infections. Similarly, in infections with two parasites, the numbers ofNippostrongyluswere reduced when concurrent withMoniliformisand the dry weights ofMoniliformisandHymenolepisdecreased in the presence of each other. A comparison of the concurrent infections themselves revealed thatMoniliformisweighed significantly less in the presence ofHymenolepisthan in the three parasite infections. Parasite interactions and their possible mechanism are discussed and comparisons are made with the relevant single infection for each parasite.

scholarly journals Interleukin (IL)-4-independent immunoglobulin class switch to immunoglobulin (Ig)E in the mouse.

1996 ◽  
Vol 184 (5) ◽  
pp. 1651-1661 ◽  
Author(s):  
R A Morawetz ◽  
L Gabriele ◽  
L V Rizzo ◽  
N Noben-Trauth ◽  
R Kühn ◽  
...  
Keyword(s):  
Elevated Serum ◽  
Cell Contact ◽  
Nippostrongylus Brasiliensis ◽  
Class Switching ◽  
Antibody Treatment ◽  
Simultaneous Treatment ◽  
Retroviral Infection ◽  
Serum Ige ◽  
Class Switch ◽  
Immunodeficiency Syndrome

Immunoglobulin (Ig) class switching in B cells is regulated by stimuli transduced by cytokines and cell-cell contact. Among these stimuli, interleukin (IL)-4 has been considered an absolute prerequisite for class switching to IgE in the mouse. Here we report that IL-4-deficient (IL-4-/-) and wildtype mice had comparably elevated serum IgE levels during the course of a murine retrovirus-induced immunodeficiency syndrome, MAIDS. IgE switching in IL-4-/- mice was also induced by injection of anti-IgD antibody. Treatment with anti-IgD induced germline epsilon (g epsilon) transcripts with comparable efficiency in IL-4-/- mice and controls, but the levels of productive epsilon transcripts (p epsilon) were lower by a factor of 200 and serum IgE levels were lower by a factor of 300 in IL-4-/- mice as compared with controls. Induction of g epsilon after anti-IgD treatment of IL-4-/- mice was unaffected by simultaneous treatment with monoclonal antibodies to IL-4 and IL-4 receptor alpha chain. Infection of IL-4-/- mice with Nippostrongylus brasiliensis, a potent stimulus for IgE production, resulted in induction of g epsilon transcripts; however, p epsilon transcripts were barely detectable and serum IgE was not detected. These findings establish a novel IL-4-independent pathway for IgE switching in the mouse that is strongly activated in retroviral infection but weakly in nematode infection. This pathway appears to be dependent on distinct factors that separately control induction of g epsilon transcription and switch recombination to p epsilon.

scholarly journals R. rattus y R. norvegicus, como reservorio de endoparásitos zoonóticos en Ecuador

2021 ◽  
Vol 26 (3) ◽  
pp. e1260
Author(s):  
Luis Fernando Solorzano-Alava ◽  
Francisco Ivan Sanchez-Amador ◽  
Sunny Sanchez-Giler ◽  
Jaime Pizarro V
Keyword(s):  
Hymenolepis Diminuta ◽  
Nippostrongylus Brasiliensis ◽  
Cysticercus Fasciolaris ◽  
Moniliformis Moniliformis

Objetivo. Recolectar información sobre la presencia de parasitosis intestinales en roedores, con énfasis en parásitos de importancia médica en humanos. Materiales y métodos. Se realizó un estudio parasitológico para detectar la presencia de helmintos en roedores en zonas urbanas y rurales de cinco provincias del Ecuador entre el 2014 y 2017. Los roedores fueron capturados y transportados al Centro Referencia Nacional de Parasitología del Instituto Nacional de Investigación en Salud Pública – Guayaquil, para su posterior análisis. Resultados. Se encontraron 125/211 (59.2%) ratas con endoparásitos, 13/20 (65%) R. rattus y 112/191 (58.6%) R. norvegicus. El nemátodo más prevalente fue Nippostrongylus brasiliensis (para ambas especies de roedores), y Heterakis spumosa, seguido por los cestodos: Hymenolepis diminuta, H. nana, Moniliformis moniliformis y Cysticercus fasciolaris. Conclusiones. La presencia de cuatro especies de cestodos zoonóticos en los roedores muestreados que viven cerca comunidades humanas, representan un riesgo potencial de infecciónpara los habitantes, especialmente en el caso de R. norvegicus (presento mayor diversidad de especies parasitarias).Por lo tanto, el control de la población de roedores en las áreas residenciales y las recomendaciones a la población local sobre el riesgo de transmisión de enfermedades a través de roedores parece ser totalmente necesario.

Serum immunoglobulin E reactivity to cross-reacting panallergen components in north-eastern Poland patients pollen sensitized

2020 ◽  
Vol 41 (3) ◽  
pp. 183-191
Author(s):  
Krzysztof Kowal ◽  
Agnieszka Pampuch ◽  
Ewa Sacharzewska ◽  
Ewa Swiebocka ◽  
Zenon Siergiejko ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Allergen Immunotherapy ◽  
Immunoglobulin E ◽  
Pollen Allergy ◽  
Serum Ige ◽  
Ige Reactivity ◽  
Allergen Components ◽  
North Eastern ◽  
Allergen Sources ◽  
Seasonal Pollen

Background: The presence of immunoglobulin E (IgE), which cross-reacts with allergen components, such as profilins, polcalcins, and cross-reacting carbohydrate determinants (CCD), creates a problem when selecting patients for allergen immunotherapy by using conventional methods. The aim of this study was to evaluate the prevalence of sensitization to profilins, polcalcins, and CCDs in patients with seasonal pollen allergic rhinitis. Methods: The study was performed on a group of 112 patients with seasonal pollen allergic rhinitis, ages 14 to 55 years, with sensitization to at least one seasonal allergen (IgE > 0.7 kUA/L). The presence of IgE sensitization to recombinant (r) Bet v 2, rPhl p 12, rBet v 4, rPhl p 7, and CCDs, in addition to rBet v 1, rPhl p 1, rPhl p 5, was evaluated by using a multiparameter immunoblot. Results: Among the studied patients, 64.3, 80.4, and 41.1% were sensitized to birch, timothy grass, and mugwort pollen, respectively. Sensitization to profilins rBet v 2/Phl p 12 was demonstrated in 28.6%, to polcalcins Bet v 4/Phl p 7 in 8.9%, and to CCDs in 25%. In 29.3%, serum IgE reactivity to any of the cross-reactive components could be demonstrated. Serum IgE reactivity to rBet v 2 was always accompanied by IgE reactivity to rPhl p 12, and IgE reactivity to rBet v 4 was always accompanied by IgE reactivity to rPhl p 7. Among the patients with pollinosis co-sensitized to at least two allergen sources according to extract-based diagnosis, possible false-positive results due to sensitization to cross-reactive components were detected in 17.9%. Conclusion: Evaluation of sensitization to cross-reacting components may be useful in evaluation of patients with pollen allergy who are being assessed for allergen immunotherapy to optimize the constitution of their immunotherapy vaccines.

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