The serine-rich cytoplasmic domain of the interleukin-2 receptor beta chain is essential for interleukin-2-dependent tyrosine protein kinase and phosphatidylinositol-3-kinase activation.

I. Merida; P. Williamson; W.A. Kuziel; W.C. Greene; G.N. Gaulton

doi:10.1016/s0021-9258(18)53315-9

The serine-rich cytoplasmic domain of the interleukin-2 receptor beta chain is essential for interleukin-2-dependent tyrosine protein kinase and phosphatidylinositol-3-kinase activation.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)53315-9 ◽

1993 ◽

Vol 268 (9) ◽

pp. 6765-6770

Author(s):

I. Merida ◽

P. Williamson ◽

W.A. Kuziel ◽

W.C. Greene ◽

G.N. Gaulton

Keyword(s):

Protein Kinase ◽

Interleukin 2 ◽

Cytoplasmic Domain ◽

Beta Chain ◽

Phosphatidylinositol 3 Kinase ◽

Kinase Activation ◽

Interleukin 2 Receptor ◽

Tyrosine Protein Kinase ◽

Receptor Beta ◽

Phosphatidylinositol 3

Download Full-text

SH2-dependent association of phosphatidylinositol 3'-kinase 85-kDa regulatory subunit with the interleukin-2 receptor beta chain.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(17)37552-x ◽

1994 ◽

Vol 269 (8) ◽

pp. 5937-5943

Author(s):

K.E. Truitt ◽

G.B. Mills ◽

C.W. Turck ◽

J.B. Imboden

Keyword(s):

Interleukin 2 ◽

Regulatory Subunit ◽

Beta Chain ◽

Phosphatidylinositol 3 Kinase ◽

Interleukin 2 Receptor ◽

Receptor Beta ◽

Phosphatidylinositol 3

Download Full-text

The cytoplasmic domain of the interleukin-2 receptor beta chain contains both unique and functionally redundant signal transduction elements.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(17)36681-4 ◽

1994 ◽

Vol 269 (20) ◽

pp. 14698-14704 ◽

Cited By ~ 7

Author(s):

M.A. Goldsmith ◽

W. Xu ◽

M.C. Amaral ◽

E.S. Kuczek ◽

W.C. Greene

Keyword(s):

Signal Transduction ◽

Interleukin 2 ◽

Cytoplasmic Domain ◽

Beta Chain ◽

Interleukin 2 Receptor ◽

Redundant Signal ◽

Receptor Beta

Download Full-text

Phosphatidylinositol 3-Kinase Links the Interleukin-2 Receptor to Protein Kinase B and p70 S6 Kinase

Journal of Biological Chemistry ◽

10.1074/jbc.272.22.14426 ◽

1997 ◽

Vol 272 (22) ◽

pp. 14426-14433 ◽

Cited By ~ 118

Author(s):

Karin Reif ◽

Boudewijn M. T. Burgering ◽

Doreen A. Cantrell

Keyword(s):

Protein Kinase ◽

Protein Kinase B ◽

Interleukin 2 ◽

Phosphatidylinositol 3 Kinase ◽

S6 Kinase ◽

P70 S6 Kinase ◽

Interleukin 2 Receptor ◽

Phosphatidylinositol 3

Download Full-text

Insulin-induced egr-1 and c-fos expression in 32D cells requires insulin receptor, Shc, and mitogen-activated protein kinase, but not insulin receptor substrate-1 and phosphatidylinositol 3-kinase activation.

Journal of Biological Chemistry ◽

10.1074/s0021-9258(19)67421-1 ◽

2001 ◽

Vol 272 (5) ◽

pp. 3124

Author(s):

Shuko Harada ◽

Robert M. Smith ◽

Judith A. Smith ◽

Morris F. White ◽

Leonard Jarett

Keyword(s):

Protein Kinase ◽

Insulin Receptor ◽

Mitogen Activated Protein Kinase ◽

Insulin Receptor Substrate ◽

Phosphatidylinositol 3 Kinase ◽

Insulin Receptor Substrate 1 ◽

Kinase Activation ◽

Mitogen Activated Protein ◽

Fos Expression ◽

Phosphatidylinositol 3

Download Full-text

Identification of three adjacent amino acids of interleukin-2 receptor beta chain which control the affinity and the specificity of the interaction with interleukin-2.

The EMBO Journal ◽

10.1002/j.1460-2075.1992.tb05262.x ◽

1992 ◽

Vol 11 (6) ◽

pp. 2047-2053 ◽

Cited By ~ 25

Author(s):

J.L. Imler ◽

A. Miyajima ◽

G. Zurawski

Keyword(s):

Amino Acids ◽

Interleukin 2 ◽

Beta Chain ◽

Interleukin 2 Receptor ◽

Receptor Beta

Download Full-text

Interleukin-2 receptor beta chain gene: generation of three receptor forms by cloned human alpha and beta chain cDNA's

Science ◽

10.1126/science.2785715 ◽

1989 ◽

Vol 244 (4904) ◽

pp. 551-556 ◽

Cited By ~ 432

Author(s):

M Hatakeyama ◽

M Tsudo ◽

S Minamoto ◽

T Kono ◽

T Doi ◽

...

Keyword(s):

Interleukin 2 ◽

Chain Gene ◽

Beta Chain ◽

Interleukin 2 Receptor ◽

Receptor Beta

Download Full-text

Abstract 2326: LTX-315, an oncolytic peptide, increases anticancer immunity mediated by CTLA4 blockade in an interleukin-2 receptor beta-chain-dependent manner

10.1158/1538-7445.am2016-2326 ◽

2016 ◽

Author(s):

Takahiro Yamazaki ◽

Marie Vetizou ◽

Camila Flores ◽

Aurelien Marabelle ◽

Baldur Sveinbjørnsson ◽

...

Keyword(s):

Interleukin 2 ◽

Dependent Manner ◽

Beta Chain ◽

Interleukin 2 Receptor ◽

Ctla4 Blockade ◽

Receptor Beta ◽

Anticancer Immunity

Download Full-text

Protein kinase C modulates negatively the hepatocyte growth factor-induced migration, integrin expression and phosphatidylinositol 3-kinase activation

Cellular Signalling ◽

10.1016/j.cellsig.2003.09.009 ◽

2004 ◽

Vol 16 (4) ◽

pp. 505-513 ◽

Cited By ~ 6

Author(s):

Annamária Gujdár ◽

Szabolcs Sipeki ◽

Erzsébet Bander ◽

László Buday ◽

Anna Faragó

Keyword(s):

Protein Kinase C ◽

Growth Factor ◽

Protein Kinase ◽

Hepatocyte Growth Factor ◽

Integrin Expression ◽

Phosphatidylinositol 3 Kinase ◽

Kinase Activation ◽

Kinase C ◽

Hepatocyte Growth ◽

Phosphatidylinositol 3

Download Full-text

Human interleukin 2 receptor beta-chain gene: chromosomal localization and identification of 5' regulatory sequences.

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.87.9.3440 ◽

1990 ◽

Vol 87 (9) ◽

pp. 3440-3444 ◽

Cited By ~ 36

Author(s):

J. R. Gnarra ◽

H. Otani ◽

M. G. Wang ◽

O. W. McBride ◽

M. Sharon ◽

...

Keyword(s):

Chromosomal Localization ◽

Interleukin 2 ◽

Chain Gene ◽

Regulatory Sequences ◽

Beta Chain ◽

Interleukin 2 Receptor ◽

Receptor Beta

Download Full-text

c-fos gene induction by interleukin 2: identification of the critical cytoplasmic regions within the interleukin 2 receptor beta chain.

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.89.6.2022 ◽

1992 ◽

Vol 89 (6) ◽

pp. 2022-2026 ◽

Cited By ~ 31

Author(s):

M. Hatakeyama ◽

A. Kawahara ◽

H. Mori ◽

H. Shibuya ◽

T. Taniguchi

Keyword(s):

Interleukin 2 ◽

Gene Induction ◽

Beta Chain ◽

Interleukin 2 Receptor ◽

Receptor Beta

Download Full-text