scholarly journals In situ Phosphorylation of Platelet Actin-binding Protein by cAMP-dependent Protein Kinase Stabilizes It against Proteolysis by Calpain

1989 ◽  
Vol 264 (24) ◽  
pp. 14282-14289 ◽  
Author(s):  
M Chen ◽  
A Stracher
Keyword(s):  
Protein Kinase ◽  
Binding Protein ◽  
Actin Binding ◽  
Dependent Protein Kinase ◽  
Actin Binding Protein ◽  
Camp Dependent Protein Kinase ◽  
Dependent Protein

In situ regulation of cell-cell communication by the cAMP-dependent protein kinase and protein kinase C

1993 ◽  
pp. 293-307 ◽  
Author(s):  
Angela J. Godwin ◽  
Lora M. Green ◽  
Michael P. Walsh ◽  
John R. McDonald ◽  
Donal A. Walsh ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Cell Communication ◽  
Dependent Protein Kinase ◽  
Camp Dependent Protein Kinase ◽  
Kinase C ◽  
Dependent Protein ◽  
Cell Cell

Determination of a cAMP-Dependent Protein Kinase Phosphorylation Site in the C-Terminal Region of Human Endothelial Actin-Binding Protein

2000 ◽  
Vol 377 (1) ◽  
pp. 80-84 ◽  
Author(s):  
David Jay ◽  
Elizabeth J. García ◽  
José Enrique Lara ◽  
Miguel Angel Medina ◽  
María de la Luz Ibarra
Keyword(s):  
Protein Kinase ◽  
Phosphorylation Site ◽  
Terminal Region ◽  
Actin Binding ◽  
Dependent Protein Kinase ◽  
Actin Binding Protein ◽  
Dependent Protein ◽  
Kinase Phosphorylation ◽  
Protein Kinase Phosphorylation Site

Regulation of lung epithelial cell morphology by cAMP-dependent protein kinase type I isozyme

2001 ◽  
Vol 280 (6) ◽  
pp. L1282-L1289 ◽  
Author(s):  
Stephanie E. Porter ◽  
Lori D. Dwyer-Nield ◽  
Alvin M. Malkinson
Keyword(s):  
Protein Kinase ◽  
Cell Junctions ◽  
Actin Binding ◽  
Regulatory Subunit ◽  
Type I ◽  
Stable Transfection ◽  
Dependent Protein Kinase ◽  
Camp Dependent Protein Kinase ◽  
Lung Epithelial ◽  
Dependent Protein

Cell shape is mediated in part by the actin cytoskeleton and the actin-binding protein vinculin. These proteins in turn are regulated by protein phosphorylation. We assessed the contribution of cAMP-dependent protein kinase A isozyme I (PKA I) to lung epithelial morphology using the E10/E9 sibling cell lines. PKA I concentration is high in flattened, nontumorigenic E10 cells but low in their round E9 transformants. PKA I activity was lowered in E10 cells by stable transfection with a dominant negative RIα mutant of the PKA I regulatory subunit and was raised in E9 cells by stable transfection with a wild-type Cα catalytic subunit construct. Reciprocal changes in morphology ensued. E10 cells became rounder and grew in colonies, their actin microfilaments were disrupted, and vinculin localization at cell-cell junctions was diminished. The converse occurred in E9 cells on elevating their PKA I content. Demonstration that PKA I is responsible for the dichotomy in these cellular behaviors suggests that manipulating PKA I concentrations in lung cancer would provide useful adjuvant therapy.

Actin binding of human LIM and SH3 Protein (LASP) is regulated by cGMP-and cAMP-dependent protein kinase phosphorylation on serine 146

2003 ◽  
Vol 3 (S2) ◽  
Author(s):  
Elke Butt ◽  
Christian Kaicher ◽  
Stepan Gambaryan ◽  
Nina Göttfert ◽  
Annette Galler ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Actin Binding ◽  
Dependent Protein Kinase ◽  
Camp Dependent Protein Kinase ◽  
Dependent Protein ◽  
Kinase Phosphorylation
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