scholarly journals THE INFLUENCE OF THE SODIUM AND POTASSIUM CONTENT OF THE DIET UPON THE SODIUM CONCENTRATION OF HUMAN CENTRIFUGED RED BLOOD CELLS

1934 ◽  
Vol 106 (1) ◽  
pp. 107-112
Author(s):  
Allan M. Butler ◽  
Eaton M. MacKay
1977 ◽  
Vol 57 (4) ◽  
pp. 193-198
Author(s):  
L. Vettore ◽  
M.C. de Matteis ◽  
G. del Conte

1979 ◽  
Vol 73 (1) ◽  
pp. 61-71 ◽  
Author(s):  
V Castranova ◽  
J F Hoffman

After incubation in isotonic KCl, dog red blood cells can be separated by centrifugation into subgroups which assume different cell volumes and possess different transport characteristics. Those red cells which swell in isotonic KCl exhibit a higher permeability to K and possess a greater volume dependence for transport of K than those red cells which shrink. A high Na permeability characterizes cells which shrink in isotonic KCl and these cells exhibit a larger volume-dependent Na flux than those red cells which swell. These two subgroups of red cells do not seem to represent two cell populations of different age. The results indicate that the population of normal cells is evidently heterogeneous in that the volume-dependent changes in Na and K permeability are distributed between differnt cell types rather than representing a single cell type which reciprocally changes its selectivity to Na and K.


1975 ◽  
Vol 65 (1) ◽  
pp. 84-96 ◽  
Author(s):  
J C Parker ◽  
H J Gitelman ◽  
P S Glosson ◽  
D L Leonard

Dog red blood cells (RBC) are shown to regulate their volume in anisosmotic media. Extrusion of water from osmotically swollen cells requires external calcium and is associated with net outward sodium movement. Accumulation of water by osmotically shrunken cells is not calcium dependent and is associated with net sodium uptake. Net movements of calcium are influenced by several variables including cell volume, pH, medium sodium concentration, and cellular sodium concentration. Osmotic swelling of cells increases calcium permeability, and this effect is diminished at acid pH. Net calcium flux in either direction between cells and medium is facilitated when the sodium concentrations is low in the compartment from which calcium moves and/or high in the compartment to which calcium moves. The hypothesis is advanced that energy for active sodium extrusion in dog RBC comes from passive, inward flow of calcium through a countertransport mechanism.


Nature ◽  
1955 ◽  
Vol 176 (4473) ◽  
pp. 171-171 ◽  
Author(s):  
J. V. EVANS ◽  
J. W. B. KING

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