scholarly journals High density lipoproteins influence cholesterol homeostasis in cultured virus-transformed human lymphoblastoid cells. Dependence on the lipoprotein concentration in the medium.

1982 ◽  
Vol 257 (23) ◽  
pp. 14280-14287
Author(s):  
A I Leikin ◽  
M Mihovilovic ◽  
A M Scanu
Keyword(s):  
High Density ◽  
Cholesterol Homeostasis ◽  
High Density Lipoproteins ◽  
Lymphoblastoid Cells ◽  
Lipoprotein Concentration

scholarly journals X-Irradiation and Lipoprotein Metabolism in Various Species

1956 ◽  
Vol 185 (2) ◽  
pp. 257-264 ◽  
Author(s):  
John E. Hewitt ◽  
Thomas L. Hayes
Keyword(s):  
Lipoprotein Metabolism ◽  
Low Density Lipoproteins ◽  
High Density ◽  
High Density Lipoproteins ◽  
Low Density ◽  
Pronounced Decrease ◽  
Density Class ◽  
Lipoprotein Concentration ◽  
X Irradiation ◽  
Quantitative Changes

The changes in lipoprotein concentration following x-irradiation have been presented for the rabbit, dog, rat and mouse. The most striking lipoprotein changes in the four species were: a) a large increase in the concentration of the low density lipoproteins of the rabbit at 30 hours postirradiation; b) increased concentrations of the two lower density classes and decreased concentrations in the highest density class in the dog at 10–13 days postirradiation; c) elevated concentrations of the high density lipoproteins at 3 days and the low density lipoproteins at 8 days in the rat; d) a pronounced decrease in the concentrations of the high density lipoproteins of the mouse at 4 days. Hyperlipoproteinemia is associated with higher average flotation rates for the lipoprotein molecules, indicating qualitative as well as quantitative changes in the metabolism of lipids in the irradiated animal. A relatively large increase in the concentration of the low density lipoproteins precedes death from irradiation in the rabbit, rat and dog.

scholarly journals Importance of Apolipoprotein A-I and A-II Composition in HDL and Its Potential for Studying COVID-19 and SARS-CoV-2

Medicines ◽  
2021 ◽  
Vol 8 (7) ◽  
pp. 38
Author(s):  
Kyung-Hyun Cho
Keyword(s):  
Antiviral Activity ◽  
High Density ◽  
High Density Lipoproteins ◽  
Potent Antiviral Activity ◽  
Apolipoprotein A ◽  
Putative Role

The composition and properties of apolipoprotein (apo) A-I and apoA-II in high-density lipoproteins (HDL) might be critical to SARS-CoV-2 infection via SR-BI and antiviral activity against COVID-19. HDL containing native apoA-I showed potent antiviral activity, while HDL containing glycated apoA-I or other apolipoproteins did not. However, there has been no report to elucidate the putative role of apoA-II in the antiviral activity of HDL.

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