scholarly journals On the simultaneous binding of eukaryotic DNA topoisomerase II to a pair of double-stranded DNA helices

1993 ◽  
Vol 268 (19) ◽  
pp. 14250-14255
Author(s):  
J. Roca ◽  
J.M. Berger ◽  
J.C. Wang
Keyword(s):  
Topoisomerase Ii ◽  
Dna Topoisomerase Ii ◽  
Dna Topoisomerase ◽  
Double Stranded Dna ◽  
Eukaryotic Dna

scholarly journals ATPase Domain of Eukaryotic DNA Topoisomerase II

2001 ◽  
Vol 277 (8) ◽  
pp. 5944-5951 ◽  
Author(s):  
Tao Hu ◽  
Harvey Sage ◽  
Tao-shih Hsieh
Keyword(s):  
Topoisomerase Ii ◽  
Dna Topoisomerase Ii ◽  
Atpase Domain ◽  
Dna Topoisomerase ◽  
Eukaryotic Dna

scholarly journals Cell Cycle-Dependent Control and Roles of DNA Topoisomerase II

Genes ◽  
2019 ◽  
Vol 10 (11) ◽  
pp. 859 ◽  
Author(s):  
Joyce H. Lee ◽  
James M. Berger
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Progression ◽  
Topoisomerase Ii ◽  
Type Ii ◽  
Dna Topoisomerase Ii ◽  
Dna Topoisomerase ◽  
Cycle Progression ◽  
Double Stranded Dna ◽  
Topo Ii ◽  
Cycle Dependent

Type II topoisomerases are ubiquitous enzymes in all branches of life that can alter DNA superhelicity and unlink double-stranded DNA segments during processes such as replication and transcription. In cells, type II topoisomerases are particularly useful for their ability to disentangle newly-replicated sister chromosomes. Growing lines of evidence indicate that eukaryotic topoisomerase II (topo II) activity is monitored and regulated throughout the cell cycle. Here, we discuss the various roles of topo II throughout the cell cycle, as well as mechanisms that have been found to govern and/or respond to topo II function and dysfunction. Knowledge of how topo II activity is controlled during cell cycle progression is important for understanding how its misregulation can contribute to genetic instability and how modulatory pathways may be exploited to advance chemotherapeutic development.

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