A reliable and reproducible reversed-phase high performance liquid chromatography (RP-HPLC) was developed for the
quantitative determination of Remipril drug content from marketed bulk tablets. The active ingredient of Remipril
separation achieved with C18 column using the methanol water mobile phase in the ratio of 40:60 (v/v). The active
ingredient of the drug content quantify with UV detector at 215 nm. The retention time of Remipril is 5.63 min. A good
linearity relation (R2=0.999) was obtained between drug concentration and average peak areas. The limit of detection and
limit of quantification of the instrument were calculated 0.03 and 0.09 µg/mL, respectively. The accuracy of the method
validation was determined 102.72% by recoveries method.