Prenatal and perinatal factors and cerebral palsy in very low birth weight infants

1996 ◽  
Vol 128 (3) ◽  
pp. 407-414 ◽  
Author(s):  
Judith K. Grether ◽  
Karin B. Nelson ◽  
E.Stanley Emery ◽  
Susan K. Cummins
Keyword(s):  
Cerebral Palsy ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Very Low Birth Weight ◽  
Perinatal Factors ◽  
Low Birth Weight Infants

scholarly journals Neurodevelopmental outcome of preterm very low birth weight infants admitted to an Italian tertiary center over an 11-year period

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Stefania Longo ◽  
Camilla Caporali ◽  
Camilla Pisoni ◽  
Alessandro Borghesi ◽  
Gianfranco Perotti ◽  
...  
Keyword(s):  
Cerebral Palsy ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Very Low Birth Weight ◽  
Neurodevelopmental Outcome ◽  
International Studies ◽  
Perinatal Complications ◽  
Neurological Assessment ◽  
Low Birth Weight Infants ◽  
Tertiary Center

AbstractPreterm very low birth weight infants (VLBWi) are known to be at greater risk of adverse neurodevelopmental outcome. Identifying early factors associated with outcome is essential in order to refer patients for early intervention. Few studies have investigated neurodevelopmental outcome in Italian VLBWi. The aim of our longitudinal study is to describe neurodevelopmental outcome at 24 months of corrected age in an eleven-year cohort of 502 Italian preterm VLBWi and to identify associations with outcome. At 24 months, Griffiths’ Mental Developmental Scales were administered. Neurodevelopmental outcome was classified as: normal, minor sequelae (minor neurological signs, General Quotient between 76 and 87), major sequelae (cerebral palsy; General Quotient ≤ 75; severe sensory impairment). 75.3% showed a normal outcome, 13.9% minor sequelae and 10.8% major sequelae (3.8% cerebral palsy). Male gender, bronchopulmonary dysplasia, abnormal neonatal neurological assessment and severe brain ultrasound abnormalities were independently associated with poor outcome on multivariate ordered logistic regression. Rates of major sequelae are in line with international studies, as is the prevalence of developmental delay over cerebral palsy. Analysis of perinatal complications and the combination of close cUS monitoring and neurological assessment are still essential for early identification of infants with adverse outcome.

Neurodevelopmental Outcomes in Very Low-Birth-Weight Infants in Korea

2011 ◽  
Vol 26 (11) ◽  
pp. 1405-1410 ◽  
Author(s):  
Dae-Hyun Jang ◽  
In Young Sung ◽  
Jae Yong Jeon ◽  
Hye Jin Moon ◽  
Ki-Soo Kim ◽  
...  
Keyword(s):  
Cerebral Palsy ◽  
Birth Weight ◽  
Survival Rate ◽  
Low Birth Weight ◽  
Very Low Birth Weight ◽  
Low Birth Weight Infants ◽  
Neurodevelopmental Outcomes ◽  
Recent Group ◽  
Neurodevelopmental Impairment ◽  
Over Time

The authors reviewed the medical records of very low-birth-weight infants admitted from 1998 to 2007 and compared neurodevelopmental outcomes with their previously reported data from 1989 to 1997. The recent group included 824 infants, and the previous group included 471 infants. Neurodevelopmental outcomes were classified into cerebral palsy and non–cerebral palsy neurodevelopmental impairment. In the recent group, the survival rate was significantly higher (79.4% vs 66.2%), the rate of cerebral palsy was lower (7.9% vs 10.5%), and the rate of non–cerebral palsy neurodevelopmental impairment was higher (6.0% vs 4.5%) but not significant. The survival rate increased significantly over time, but there was no significant change in neurodevelopmental outcomes over time. Multivariate analysis indicated that abnormal neurosonographic findings, using assisted ventilation, vaginal delivery, and abnormal brainstem auditory evoked potential, were associated with increased risk for cerebral palsy.

Impact of Improved Survival of Very Low Birth Weight Infants on Recent Secular Trends in the Prevalence of Cerebral Palsy

PEDIATRICS ◽  
1993 ◽  
Vol 91 (6) ◽  
pp. 1094-1100
Author(s):  
Vidya Bhushan ◽  
Nigel Paneth ◽  
John L. Kiely
Keyword(s):  
United States ◽  
Cerebral Palsy ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Very Low Birth Weight ◽  
The United States ◽  
Epidemiologic Studies ◽  
Secular Trends ◽  
Industrialized Countries ◽  
Low Birth Weight Infants

Objective. To review recent secular trends in the prevalence of cerebral palsy in industrialized countries that have population-based cerebral palsy registries and to estimate such time-trends for the United States, where until recently such registries were absent. Data sources. Recent epidemiologic studies of cerebral palsy published in peer-reviewed journals in English, and US vital data bearing on the principal demographic determinants of cerebral palsy—birth rates, the birth weight distributions, birth weight-specific mortality risk, and cerebral palsy risk among survivors. Results. Most epidemiologic studies from industrialized countries show a rise in the childhood prevalence of cerebral palsy in recent decades, largely because of the increasing contribution of children of low and very low birth weight to its prevalence. The only demographic determinant of cerebral palsy prevalence that is changing rapidly in the United States is survival of low birth weight and very low birth weight infants. Based on the magnitude of change in the survival of low and very low birth weight infants, it is estimated that childhood prevalence of cerebral palsy rose about 20% between 1960 and 1986 in the United States. Conclusion. An apparently unavoidable side effect of the increasing success of newborn intensive care is a moderate rise in the childhood prevalence of cerebral palsy.

Cerebral Palsy in Very Low Birth Weight Infants, Pre-eclampsia and Magnesium Sulphate

PEDIATRICS ◽  
1996 ◽  
Vol 97 (5) ◽  
pp. 780-781
Author(s):  
Eve Blair ◽  
Lyle Palmer ◽  
Fiona Stanley
Keyword(s):  
Cerebral Palsy ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Magnesium Sulphate ◽  
Very Low Birth Weight ◽  
Causal Explanation ◽  
Controlled Trial ◽  
Retrospective Data ◽  
Low Birth Weight Infants ◽  
Randomized Controlled

Nelson and Grether1 (Pediatrics 1995;95:263-269) hypothesize that magnesium sulphate administered to mothers before delivery of very low birth weight ([VLBW] <1500 g) infants reduces their risk of cerebral palsy (CP). This hypothesis is supported by their analysis of retrospective data pertaining to VLBW Californian infants. Although it is an exciting proposition, it needs to be approached with caution. A causal explanation for the observed association needs to be confirmed with a randomized controlled trial of magnesium sulphate in preterm delivery because it is conceivable that the apparently robust association may have resulted from their study design.2

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