RENAL CELL CARCINOMA: MANAGEMENT OF ADVANCED DISEASE

1999 ◽  
Vol 161 (2) ◽  
pp. 381-387 ◽  
Author(s):  
ROBERT A. FIGLIN
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Advanced Disease

Using prostate specific membrane antigen (PSMA) expression in clear cell renal cell carcinoma for imaging advanced disease

Pathology ◽  
2016 ◽  
Vol 48 (6) ◽  
pp. 613-616 ◽  
Author(s):  
Handoo Rhee ◽  
Keng Lim Ng ◽  
Brian Wan-Chi Tse ◽  
Mei-Chun Yeh ◽  
Pamela J. Russell ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Advanced Disease ◽  
Prostate Specific Membrane Antigen ◽  
Cell Renal Cell Carcinoma ◽  
Specific Membrane ◽  
Psma Expression

scholarly journals Strong Expression of Chemokine ReceptorCXCR4 by Renal Cell Carcinoma Correlates with Advanced Disease

2008 ◽  
Vol 2008 ◽  
pp. 1-6 ◽  
Author(s):  
Thomas C. Wehler ◽  
Claudine Graf ◽  
Stefan Biesterfeld ◽  
Walburgis Brenner ◽  
Jörg Schadt ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Chemokine Receptor ◽  
Renal Cell ◽  
Immune Escape ◽  
Advanced Disease ◽  
Patient Characteristics ◽  
Human Renal Cell Carcinoma ◽  
Tumor Dissemination ◽  
Tumor Entities

Diverse chemokines and their receptors have been associated with tumor growth, tumor dissemination, and local immune escape. In different tumor entities, the level of chemokine receptorCXCR4 expression has been linked with tumor progression and decreased survival. The aim of this study was to evaluate the influence ofCXCR4 expression on the progression of human renal cell carcinoma.CXCR4 expression of renal cell carcinoma was assessed by immunohistochemistry in 113 patients. Intensity ofCXCR4 expression was correlated with both tumor and patient characteristics. Human renal cell carcinoma revealed variable intensities ofCXCR4 expression. StrongCXCR4 expression of renal cell carcinoma was significantly associated with advanced T-status (P=.039), tumor dedifferentiation (P= .0005), and low hemoglobin (P= .039). In summary, strongCXCR4 expression was significantly associated with advanced dedifferentiated renal cell carcinoma.

scholarly journals Clinical- pathological features and surgical outcome of renal cell carcinoma: Experience from a zonal referral hospital-northern of Tanzania

2021 ◽  
Vol 12 (2) ◽  
pp. 434-440
Author(s):  
Vitus Kajerero ◽  
Frank Bright ◽  
Orgeness J. Mbwambo ◽  
Alfred K. Mteta ◽  
Patrick Amsi ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Advanced Disease ◽  
Abdominal Mass ◽  
Significant Proportion ◽  
Flank Pain ◽  
Pathological Feature ◽  
Female Ratio

Background: Renal cell carcinoma (RCC) is the most common primary malignant tumour of kidney in adults. Recent studies from developed countries have shown that most renal tumour are currently diagnosed incidentally during screening for other disease which leads to better prognosis while few studies done in Africa still shows significant proportion of patients present with classic triad ( >10%) which is a sign of advanced disease. Objectives: This study aimed at determining clinical pathological feature and outcome of RCC in Northern zone of Tanzania. Patients and Methods: This was a hospital based descriptive retrospective cohort study conducted at Kilimanjaro Christian Medical (KCMC) from January 2002 to December 2017. Data were analysed using statistical package for social science (SPSS) version 16. 0 and summarized in tables and figures. Results: Forty three patients (43) underwent radical nephrectomy for RCC during the study period. Male to female ratio was1. 7: 1 with mean age of 53+/- 12 years. Flank pain (84%), abdominal mass (76%) and hematuria (44%) were the most common clinical presentation while classical triad was found in 40%. The most common clinical tumor stage was T3(72. 1%) whilst clear cell carcinoma was the commonest histological pattern. Five years survival length for T1, T2, T3 and T4 were 100%, 62. 5%, 32. 3% and 0% respectively. Conclusion: The most common presenting symptom of RCC in our centre is flank pain, and abdominal mass. Majority of the patients presented with advanced disease with less than five year survival rate. Clear cell type was the predominant histological type.

Renal Cell Carcinoma With Tumor Thrombus: Is Cytoreductive Nephrectomy For Advanced Disease Associated With An Increased Complication Rate?

2002 ◽  
Vol 168 (3) ◽  
pp. 962-967 ◽  
Author(s):  
Amnon Zisman ◽  
Allan J. Pantuck ◽  
Debby H. Chao ◽  
Jeff A. Wieder ◽  
Frederick Dorey ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Complication Rate ◽  
Renal Cell ◽  
Tumor Thrombus ◽  
Advanced Disease ◽  
Cytoreductive Nephrectomy

Cigarette Smoking Is Associated With Advanced Renal Cell Carcinoma

2011 ◽  
Vol 29 (15) ◽  
pp. 2027-2031 ◽  
Author(s):  
Matvey Tsivian ◽  
Daniel M. Moreira ◽  
Jorge R. Caso ◽  
Vladimir Mouraviev ◽  
Thomas J. Polascik
Keyword(s):  
Renal Cell Carcinoma ◽  
Smoking Cessation ◽  
Risk Factor ◽  
Cigarette Smoking ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Multivariate Analyses ◽  
Advanced Disease ◽  
Cumulative Exposure ◽  
Former Smokers

Purpose Cigarette smoking is a recognized risk factor for renal cell carcinoma (RCC), but little data are available on the association between smoking and RCC biology. We investigated the association between cigarette smoking and RCC stage in a large contemporary multiethnic surgical cohort. Patients and Methods We retrospectively reviewed the demographic, clinical, and pathologic data of patients undergoing surgery for RCC between 2000 and 2009. Advanced RCC was defined as metastatic disease, pathologic stage ≥ T3, and/or lymph node involvement. Self-reported smoking history included smoking status, duration, intensity, cumulative exposure, and cessation. Patient and tumor characteristics were compared between the groups in univariate and multivariate analyses. Results Of the 845 eligible patients, 19.4% and 29.1% were current and former smokers, respectively, and 207 patients (24.5%) had advanced disease. In both univariate and multivariate analyses, smoking was consistently associated with advanced RCC, and cessation reversed the risk. Current and former smokers had 1.5- and 1.6-fold increased odds of advanced disease, respectively. Heavier smoking (longer duration and exposure) was associated with increased risk of advanced RCC, whereas durable cessation reduced the odds of advanced disease. Conclusion Cigarette smoking is an independent risk factor for advanced RCC. Heavier smoking increases the likelihood of advanced disease. Durable smoking cessation attenuated the risk of advanced disease. Given that cigarette smoking is among the few modifiable risk factors for RCC, our results reinforce the importance of smoking cessation and encourage further investigation of the association between smoking and RCC biology.

scholarly journals Origins and timing of emerging lesions in advanced renal cell carcinoma

2021 ◽  
Author(s):  
Andrew Wallace ◽  
Sima Porten ◽  
Amy A. Lo ◽  
Daniel Oreper ◽  
Nicolas Lounsbury ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Primary Tumor ◽  
Renal Cell ◽  
Advanced Disease ◽  
Timing Analysis ◽  
Treatment Strategies ◽  
Disease State ◽  
Mtor Signaling ◽  
Venous Tumor Thrombus

Purpose: Renal cell carcinoma (RCC) with venous tumor thrombus (VTT) arising from the primary tumor occurs in 4-10% of cases and is associated with advanced disease. RCC with VTT and distant metastasis represents a unique clinical entity, and provides opportunities to examine the origins and relative timing of tumor lesion emergence and to identify molecular correlates with disease state. Experimental Design: We performed genomic and evolutionary analyses on 16 RCC patients with VTT, with eight also having metastases, using multi-region exome and RNA sequencing. Results: No genomic alterations were specifically associated with the VTT or metastasis lesions; each tumor had multiple hallmark driver alterations, consistent with advanced disease state. We found that 21% (3/14) of clear-cell RCC cases could be assigned a previously defined "evolutionary subtype". Somatic mutation signatures were largely consistent with previously established RCC signatures, and showed low heterogeneity across regions of each tumor. Mismatch repair and homologous recombination ("BRCA-ness") deficiency signatures consistently co-occurred across most tumors, suggesting a pervasive role for intracellular DNA damage in RCC and the potential for related treatment strategies. Phylogenetic timing analysis of metastatic cases suggested that in most tumors, metastases branched from the primary tumor prior to formation of VTT and in some cases before diversification of the primary tumor. Both VTT and the earliest metastases were predicted to emerge many years prior to diagnosis. Transcriptional landscape analysis identified key differences distinguishing each lesion type from primary tumor: VTT upregulated TNF𝛼 signaling and associated inflammatory pathways, whereas metastases upregulated MTOR signaling. Conclusions: Our results provide a map of how RCC tumors can evolve, with metastatic clones typically emerging early in RCC development and taking hold via MTOR signaling, and later formation of VTT via local inflammatory processes.

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