MORPHOLOGICAL ANALYSIS AND CLASSIFICATION OF LATENT PROSTATE CANCER USING A 3-DIMENSIONAL COMPUTER ALGORITHM: ANALYSIS OF TUMOR VOLUME, GRADE, TUMOR DOUBLING TIME AND LIFE EXPECTANCY

Objective:To evaluate inuence of volumetric tumor doubling time on survival of patients with intracranial tumors. Study design: 20 patients with intracranial tumor of either sex and any age were included, if two imaging scans were available/could be done in which change in tomor volume was appreciable and the tumor margins were well demarcated. Based on change in tumor volume, tumor doubling time (DT) and predictive survival time (PST) were calculated. Patients were followed up for 6 months or longer for actual survival time (AST). Results: The histological grade was found to have a signicant correlation with DT (P value 0.046) and PST of the tumor (P value 0.038). DT and PSTwere found to be signicantly lower in high grade astrocytomas. Age, gender, tumor location and initial tumor volume were not found to have a signicant correlation with DTand PST. When DTwas compared to PST, excellent correlation was seen which was statistically signicant (Pvalue < 0.001) and suggested a linear relationship. Conclusion: Computed Tomography (CT) & Magnetic Resonance Imaging (MRI) can accurately dene the intracranial tumors and can reliably measure their volume. Calculation of tumor volume, change in tumor volume, DT and PST based on imaging studies is easy and reproducible. DT and PST have an excellent correlation & there is a linear relationship between the two. Histological grade and DT are the signicant prognostic factors while age, gender, tumor location and initial tumor volume are not signicant prognostic factors in patients with brain tumors.

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PSA doubling times in patients with prostate cancer, a potentially useful reflection of tumor doubling time

International Journal of Radiation Oncology*Biology*Physics ◽

10.1016/0360-3016(92)90175-h ◽

1992 ◽

Vol 24 ◽

pp. 148 ◽

Cited By ~ 2

Author(s):

Gerald E. Hanks ◽

Barry E. Epstein ◽

Ruth Peter ◽

Timothy E. Schultheiss

Keyword(s):

Prostate Cancer ◽

Doubling Time ◽

Tumor Doubling Time ◽

Doubling Times

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Consensus on the Treatment and Follow-Up for the Nonmetastatic Castration-Resistant Prostate Cancer: A Report From the First Prostate Cancer Consensus Conference for Developing Countries

JCO Global Oncology ◽

10.1200/go.20.00507 ◽

2021 ◽

pp. 545-549

Author(s):

Felipe Moraes Toledo Pereira ◽

Adriano Gonçalves e Silva ◽

Aldo Lourenço Abbade Dettino ◽

Ana Paula Garcia Cardoso ◽

Andre Deeke Sasse ◽

...

Keyword(s):

Prostate Cancer ◽

Developing Countries ◽

Life Expectancy ◽

Biochemical Recurrence ◽

Doubling Time ◽

Consensus Conference ◽

Castration Resistant Prostate Cancer ◽

Pelvic Mri ◽

Castration Resistant

PURPOSE To present a summary of the recommendations for the treatment and follow-up for the biochemical recurrence of castration-resistant prostate cancer (PCa) as acquired through a questionnaire administered at the Prostate Cancer Consensus Conference for Developing Countries. METHODS A total of 27 questions were identified as relating to this topic. Responses from the clinician were tallied and are presented in percentage format. Topics included the use of imaging in staging, treatment recommendations across different patient scenarios of life expectancy and prostate-specific antigen (PSA) doubling time, and follow-up for nonmetastatic castration-resistant PCa. RESULTS A consensus agreed that in optimal conditions, positron emission tomography-computed tomography with prostate-specific membrane antigen would be used although in limited resource situations the combined use of CT of the abdomen and pelvic (or pelvic MRI), a bone scan, and a CT of the thorax or chest x-ray was recommended. In cases when PSA levels double in < 10 months, more than 90% of clinicians agreed on the use of apalutamide or enzalutamide, regardless of life expectancy. With a doubling time of more than 10 months, > 54% of experts recommended no treatment independent of life expectancy. More than half of the experts, regardless of resources, recommended follow-up with a physical examination and PSA levels every 3-6 months and imaging only in the case of symptoms. CONCLUSION The voting results and recommendations presented in this document can be used by physicians to support management for biochemical recurrence of castration-resistant PCa in areas of limited resources. Individual clinical decision making should be supported by available data.

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Prostatic-specific antigen doubling times in patients with prostate cancer: A potentially useful reflection of tumor doubling time

International Journal of Radiation Oncology*Biology*Physics ◽

10.1016/0360-3016(93)90429-y ◽

1993 ◽

Vol 27 (1) ◽

pp. 125-127 ◽

Cited By ~ 68

Author(s):

Gerald E. Hanks ◽

Anthony D'amico ◽

Barry E. Epstein ◽

Timothy E. Schultheiss

Keyword(s):

Prostate Cancer ◽

Doubling Time ◽

Specific Antigen ◽

Prostatic Specific Antigen ◽

Tumor Doubling Time ◽

Doubling Times

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395: Nomogram Predicting 10 year Life Expectancy after Radical Prostatectomy or Radiation Therapy for Prostate Cancer

The Journal of Urology ◽

10.1016/s0022-5347(18)30648-7 ◽

2007 ◽

Vol 177 (4S) ◽

pp. 131-132 ◽

Cited By ~ 1

Author(s):

Jochen Wafz ◽

Andrea Gallina ◽

Aldo M. Bocciardi ◽

Sascha Ahyai ◽

Paul Perrotta ◽

...

Keyword(s):

Prostate Cancer ◽

Radiation Therapy ◽

Radical Prostatectomy ◽

Life Expectancy

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665: Baseline PSA and PSA Doubling Time Predict the Risk of Objective Progression and Death in Patients with T0-4 N0-2 M0 Prostate Cancer on Watchful Waiting

The Journal of Urology ◽

10.1016/s0022-5347(18)32911-2 ◽

2006 ◽

Vol 175 (4S) ◽

pp. 215-215 ◽

Cited By ~ 2

Author(s):

Urs E. Studer ◽

Laurence Collette ◽

Peter Whelan ◽

Walter Albrecht ◽

Jacques Casselman ◽

...

Keyword(s):

Prostate Cancer ◽

Doubling Time ◽

Watchful Waiting ◽

Psa Doubling Time ◽

Baseline Psa

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The tumor doubling time is a useful parameter for predicting the histological type of thymic epithelial tumors

Surgery Today ◽

10.1007/s00595-019-01822-9 ◽

2019 ◽

Vol 49 (8) ◽

pp. 656-660 ◽

Cited By ~ 1

Author(s):

Koichi Fukumoto ◽

Takayuki Fukui ◽

Koji Kawaguchi ◽

Shota Nakamura ◽

Shuhei Hakiri ◽

...

Keyword(s):

Doubling Time ◽

Histological Type ◽

Tumor Doubling Time ◽

Thymic Epithelial Tumors ◽

Epithelial Tumors

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Preparation of Catechin Nanoemulsion from Oolong Tea Leaf Waste and Its Inhibition of Prostate Cancer Cells DU-145 and Tumors in Mice

Molecules ◽

10.3390/molecules26113260 ◽

2021 ◽

Vol 26 (11) ◽

pp. 3260

Author(s):

Yu-Hsiang Lin ◽

Chi-Chung Wang ◽

Ying-Hung Lin ◽

Bing-Huei Chen

Keyword(s):

Prostate Cancer ◽

Cancer Cells ◽

Tumor Volume ◽

Tween 80 ◽

Prostate Cancer Cells ◽

Caspase 9 ◽

Oolong Tea ◽

Induced Tumors ◽

Anti Cancer ◽

Tea Leaf

Anti-cancer activity of catechin nanoemulsions prepared from Oolong tea leaf waste was studied on prostate cancer cells DU-145 and DU-145-induced tumors in mice. Catechin nanoemulsions composed of lecithin, Tween-80 and water in an appropriate proportion was prepared with high stability, particle size of 11.3 nm, zeta potential of −67.2 mV and encapsulation efficiency of 83.4%. Catechin nanoemulsions were more effective than extracts in inhibiting DU-145 cell growth, with the IC50 being 13.52 and 214.6 μg/mL, respectively, after 48 h incubation. Furthermore, both catechin nanoemulsions and extracts could raise caspase-8, caspase-9 and caspase-3 activities for DU-145 cell apoptosis, arresting the cell cycle at S and G2/M phases. Compared to control, catechin nanoemulsion at 20 μg/mL and paclitaxel at 10 μg/mL were the most effective in reducing tumor volume by 41.3% and 52.5% and tumor weight by 77.5% and 90.6% in mice, respectively, through a decrease in EGF and VEGF levels in serum.

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