1585: Prevalence and Prognostic Significance of a Tertiary Gleason Pattern in Radical Prostatectomy Specimens Among a Cohort of 3147 Consecutive Prostate Cancer Patients

2006 ◽  
Vol 175 (4S) ◽  
pp. 511-511 ◽  
Author(s):  
Thomas Steuber ◽  
Anne Brieger ◽  
Andreas Erbersdobler ◽  
Sascha Ahyai ◽  
Markus Graefen ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Radical Prostatectomy ◽  
Cancer Patients ◽  
Prognostic Significance ◽  
Gleason Pattern

PREVALENCE AND PROGNOSTIC SIGNIFICANCE OF A TERTIARY GLEASON PATTERN IN RADICAL PROSTATECTOMY SPECIMENS AMONG A CONSECUTIVE COHORT OF 3147 PROSTATE CANCER PATIENTS

2006 ◽  
Vol 5 (2) ◽  
pp. 130
Author(s):  
T. Steuber ◽  
A. Brieger ◽  
A. Erbersdobler ◽  
S. Ahyai ◽  
T. Schlomm ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Radical Prostatectomy ◽  
Cancer Patients ◽  
Prognostic Significance ◽  
Gleason Pattern

Prognostic Significance of Disseminated Tumor Cells in the Bone Marrow of Prostate Cancer Patients Treated With Neoadjuvant Hormone Treatment

2008 ◽  
Vol 26 (30) ◽  
pp. 4928-4933 ◽  
Author(s):  
Jens Köllermann ◽  
Steffen Weikert ◽  
Martin Schostak ◽  
Carsten Kempkensteffen ◽  
Klaus Kleinschmidt ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Bone Marrow ◽  
Radical Prostatectomy ◽  
Hormone Therapy ◽  
Cancer Patients ◽  
Tumor Cells ◽  
Prognostic Significance ◽  
Specific Antigen ◽  
Disseminated Tumor Cells ◽  
Significant Prognostic Factor

Purpose To explore whether the presence of occult disseminated tumor cells (DTCs) in the bone marrow before neoadjuvant hormone therapy influences the prognosis of patients with organ confined prostate cancer treated by radical prostatectomy. Patients and Methods Pretreatment bone marrow aspirates from 193 cT (1-4) pN0M0 prostate cancer patients submitted to neoadjuvant hormone therapy (mean, 8 months) followed by radical prostatectomy were immunohistochemically evaluated by anticytokeratin antibody A45-B/B3 previously validated for the detection of DTCs. Bone marrow status was compared with established clinical and histopathologic risk parameters. Patients’ outcome was evaluated using prostate-specific antigen (PSA) blood serum measurements as surrogate marker for recurrence over a median follow-up of 44 months. Results DTCs were detected in 44.6% of patients. Bone marrow status neither correlated with tumor grade and stage, nor with the pretreatment PSA risk category (all P values > .05). In the univariate Kaplan-Meier analysis, the presence of DTCs was a significant prognostic factor with respect to poor PSA progression-free survival (log-rank test P = .0035). Using a multivariable piecewise Cox regression model, the presence of DTCs was an independent predictor of PSA relapse (relative risk 1.82; P = .014). Conclusion The presence of DTCs in the bone marrow of patients with prostate cancer before neoadjuvant hormone therapy and subsequent surgery represents an independent prognostic parameter, suggesting that DTCs may contribute to the failure of current neoadjuvant hormone therapy regimens.

Prognostic significance of primary Gleason pattern in Japanese men with Gleason score 7 prostate cancer treated with radical prostatectomy

2013 ◽  
Vol 31 (8) ◽  
pp. 1511-1516 ◽  
Author(s):  
Hideaki Miyake ◽  
Mototsugu Muramaki ◽  
Junya Furukawa ◽  
Hirokazu Tanaka ◽  
Taka-aki Inoue ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Radical Prostatectomy ◽  
Gleason Score ◽  
Prognostic Significance ◽  
Japanese Men ◽  
Gleason Pattern

The Prognostic Significance of Gleason Pattern 5 in Prostate Cancer Patients Treated With Pd-103 Brachytherapy

2007 ◽  
Vol 30 (6) ◽  
pp. 597-600 ◽  
Author(s):  
Hiroki Mitsuyama ◽  
Kent Wallner ◽  
Gregory Merrick ◽  
Jeffrey Virgin ◽  
Peter Orio ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Patients ◽  
Prognostic Significance ◽  
Gleason Pattern

scholarly journals Impact of cribriform volume in Gleason pattern 4 on biochemical recurrence in prostate cancer patients who underwent robot-assisted radical prostatectomy

2020 ◽  
Vol 19 ◽  
pp. e1046-e1047
Author(s):  
K. Shimodaira ◽  
R.I. Inoue ◽  
T.H. Hashimoto ◽  
N.S. Satake ◽  
Y.N. Nakagami ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Radical Prostatectomy ◽  
Cancer Patients ◽  
Biochemical Recurrence ◽  
Robot Assisted ◽  
Gleason Pattern

Prognostic Significance of Percentage and Architectural Types of Contemporary Gleason Pattern 4 Prostate Cancer in Radical Prostatectomy

2016 ◽  
Vol 40 (10) ◽  
pp. 1400-1406 ◽  
Author(s):  
Bonnie Choy ◽  
Shane M. Pearce ◽  
Blake B. Anderson ◽  
Arieh L. Shalhav ◽  
Gregory Zagaja ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Radical Prostatectomy ◽  
Prognostic Significance ◽  
Gleason Pattern

Correlation of biologic recurrence after radical prostatectomy and a positive surgical margin with the predominant Gleason pattern on the specimen.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. e15145-e15145
Author(s):  
Yann Neuzillet ◽  
Audrey Pichon ◽  
Thierry Lebret ◽  
Jean-Pierre Raynaud ◽  
Henry Botto
Keyword(s):  
Prostate Cancer ◽  
Radical Prostatectomy ◽  
Cancer Patients ◽  
Surgical Margin ◽  
Surgical Margins ◽  
Rank Test ◽  
Multivariate Logistic Regression Model ◽  
Positive Surgical Margin ◽  
Positive Surgical Margins ◽  
Gleason Pattern

e15145 Background: The risk of biological recurrence following radical prostatectomy depends, among other factors, on surgical margins status. This study compared the prognosis of prostate cancer patients with positive surgical margins according to the predominant Gleason pattern (PrdGP). Methods: Prospective study of 247 consecutive prostate cancer patients, who underwent radical prostatectomy (RP) from 3/2007 to 12/2009, and were followed up in our institution. Pathological stage and Gleason score were determined in RP specimens by a pathological reference. Biological recurrence was defined as two consecutive values of PSA > 0.2 ng/mL. The median overall follow-up was 33 months (2 to 54 months). Biological recurrence-free survival was estimated and compared using Kaplan-Meier plots and Log rank test. A multivariate logistic regression model was done with PrdGP4, and two other predictive variables (pT≥3a, preoperative PSA level) entered as statistically significant independent predictors of biological recurrence. Results: Forty-eight patients (19.4%) had a positive surgical margins, 26 patients have PrdGP3 (54%) and 22 have PrdGP4 (46%). Whereas 7 biological recurrences were observed in PrdGP4 patients, none occurred in PrdGP3 patients. Biological recurrence-free survivals were significantly different (Log rank p=0.001). In multivariate analysis, PrdGP4 was a predictor of biological recurrence (p<0.0001, OR= 9.023, 95% CI [3.161–25.757]). Conclusions: This study demonstrates that biological recurrence after positive surgical margin are correlated with the predominant Gleason pattern assessed on radical prostatectomy specimen which s more easily evaluable than accurate margins features. Adjuvant treatment, specifically external beam radiotherapy, should be indicated in accordance to this result. [Table: see text]

The Prognostic Significance of Gleason Pattern 5 in Prostate Cancer Patients Treated with Pd 103 plus Beam Radiation Therapy

2004 ◽  
Vol 10 (5) ◽  
pp. 301-306 ◽  
Author(s):  
Tracy Sherertz ◽  
Kent Wallner ◽  
Gregory Merrick ◽  
William Cavanagh ◽  
Wayne Butler ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Radiation Therapy ◽  
Cancer Patients ◽  
Prognostic Significance ◽  
Beam Radiation ◽  
Gleason Pattern
Sign in / Sign up

Export Citation Format

Share Document