780: Carbonic Anhydrase IX (CAIX) Expression and VHL Gene Alteration as Predictors of Survival in Renal Cell Carcinoma

2004 ◽  
Vol 171 (4S) ◽  
pp. 206-207 ◽  
Author(s):  
Hideki Mukouyama ◽  
Masahiro Yao ◽  
David B. Seligson ◽  
John S. Lam ◽  
Yoji Nagashima ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Carbonic Anhydrase ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Carbonic Anhydrase Ix ◽  
Vhl Gene ◽  
Gene Alteration ◽  
Caix Expression

Prognostic and predictive values of carbonic anhydrase IX (CAIX) and pathologic features in patients with metastatic clear cell renal cell carcinoma receiving targeted therapy

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. e16067-e16067
Author(s):  
T. K. Choueiri ◽  
M. Regan ◽  
W. Oh ◽  
J. Clement ◽  
A. Amato ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Targeted Therapy ◽  
Carbonic Anhydrase ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Carbonic Anhydrase Ix ◽  
Tumor Shrinkage ◽  
Cell Component ◽  
Caix Expression

e16067 Background: Tumor Carbonic Anhydrase IX (CAIX) expression and histologic features can predict outcome in patients with metastatic renal cell carcinoma (mRCC) treated with immunotherapy. We sought to investigate the prognostic and predictive utility of such features in patients receiving VEGF-targeted therapy. Methods: We identified 118 patients with mRCC initiating first- line VEGF-targeted therapy including 94 with clinical data, clear cell histology and available tissue. Tumors were evaluated for specific histologic features and for CAIX expression by immunohistochemistry using the MN75 antibody. The relationship between these pathology findings and tumor shrinkage and other treatment outcomes was assessed. Results: Higher tumor clear cell component was independently associated with greater tumor shrinkage (p=0.02), response (p=0.02) and treatment duration (p=0.02). Patients with high vs. low tumor CAIX expression had mean tumor shrinkages of -12% vs. -5%, respectively (p=.38). There was heterogeneity in tumor responsiveness to sunitinib or sorafenib according to CAIX status (p=0.055 for interaction): mean shrinkage was -17% vs. -25% (mean difference +8%, 95% CI -14% to +31%) for sunitinib-treated patients with high vs. low tumor CAIX expression compared to -13% vs. +9% (mean difference -22%, 95% CI -42% to -1%) for sorafenib-treated patients. Conclusions: Patients with higher clear cell component in their tumors are likely to experience superior clinical benefit from VEGF-targeted therapy. Although CAIX expression was not found to be of prognostic value in patients with clear cell mRCC treated with VEGF-targeted therapy, it may be a predictive biomarker for response to sorafenib treatment. [Table: see text]

Prognostic value of carbonic anhydrase IX and HIF-1α in renal cell carcinoma

2012 ◽  
Vol 38 (1) ◽  
pp. 1-7
Author(s):  
Bilal Gunaydin ◽  
Asif Yildirim ◽  
Ebru Zemheri ◽  
Seyma Ozkanli ◽  
Serhat Gocer ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Carbonic Anhydrase ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Prognostic Value ◽  
Carbonic Anhydrase Ix

scholarly journals Carbonic Anhydrase IX is Not a Predictor of Outcomes in Non-Metastatic Clear Cell Renal Cell Carcinoma - A Digital Analysis of Tissue Microarray

2013 ◽  
Vol 39 (4) ◽  
pp. 484-492 ◽  
Author(s):  
Marcelo Zerati ◽  
Katia R. M. Leite ◽  
Jose Pontes-Junior ◽  
Cesar Camara Segre ◽  
Sabrina Thalita Reis ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Carbonic Anhydrase ◽  
Cell Carcinoma ◽  
Tissue Microarray ◽  
Renal Cell ◽  
Clear Cell ◽  
Carbonic Anhydrase Ix ◽  
Digital Analysis ◽  
Cell Renal Cell Carcinoma

Carbonic Anhydrase IX Expression in Renal Cell Carcinoma An Immunohistochemical Study

2019 ◽  
Vol 10 (11) ◽  
pp. 2462
Author(s):  
Deepika Chandrasekaran ◽  
Anukiran ◽  
Gurunandha Raja ◽  
Sandhya Sundaram ◽  
R. Padmavathi ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Carbonic Anhydrase ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Immunohistochemical Study ◽  
Carbonic Anhydrase Ix

scholarly journals MP39-05 INHIBITION OF CARBONIC ANHYDRASE IX CONFERS RADIATION SENSITIVITY TO RENAL CELL CARCINOMA

2015 ◽  
Vol 193 (4S) ◽  
Author(s):  
Jehonathan Pinthus ◽  
Sarah Hopmans ◽  
Daniel Gallino ◽  
Carrie Gerdes ◽  
Diana Glennie ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Carbonic Anhydrase ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Radiation Sensitivity ◽  
Carbonic Anhydrase Ix
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