Role of constitutive nitric oxide synthase and peroxynitrite production in a rat model of splanchnic artery occlusion shock

Life Sciences ◽  
1998 ◽  
Vol 63 (9) ◽  
pp. 789-799 ◽  
Author(s):  
Salvatore Cuzzocrea ◽  
Basilia Zingarelli ◽  
Achille P. Caputi
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Rat Model ◽  
Artery Occlusion ◽  
Splanchnic Artery ◽  
Constitutive Nitric Oxide Synthase ◽  
Oxide Synthase

scholarly journals Effects of S-ethylisothiourea, a potent inhibitor of nitric oxide synthase, alone or in combination with a nitric oxide donor in splanchnic artery occlusion shock

1996 ◽  
Vol 119 (1) ◽  
pp. 23-28 ◽  
Author(s):  
Francesco Squadrito ◽  
Domenica Altavilla ◽  
Giovanni Squadrito ◽  
Giuseppe M. Campo ◽  
Mariapatrizia Ioculano ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Potent Inhibitor ◽  
Artery Occlusion ◽  
Nitric Oxide Donor ◽  
Splanchnic Artery ◽  
Oxide Synthase

Expression of Nitric Oxide Synthase Type 3 in Reflux-Induced Esophageal Lesions

2001 ◽  
Vol 124 (4) ◽  
pp. 442-447 ◽  
Author(s):  
Rakesh Chandra ◽  
G. Kenneth Haines ◽  
Brandon G. Bentz ◽  
Pinky Shah ◽  
Alan M. Robinson ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Squamous Epithelium ◽  
Adenocarcinoma Of The Esophagus ◽  
Squamous Mucosa ◽  
Constitutive Nitric Oxide Synthase ◽  
Oxide Synthase ◽  
Type 3 ◽  
Glandular Metaplasia

BACKGROUND: The expression of endothelial constitutive nitric oxide synthase (NOS3) by squamous dysplasia and carcinomas of the head and neck has previously been described. We sought to compare NOS3 expression in squamous mucosa, glandular metaplasia, and adenocarcinoma of the esophagus. METHODS: Forty paraffin-embedded specimens from 20 patients with adenocarcinoma were stained with anti-NOS3 monoclonal antibody. The percentage of cells stained and the intensity of staining were determined for squamous epithelium, metaplasia, and adenocarcinoma. Staining characteristics were statistically analyzed according to clinical variables. RESULTS: NOS3 expression was significantly higher in adenocarcinoma and squamous epithelium compared with glandular metaplasia. Among the carcinomas, larger tumor size (T3/4), nodal positivity, and advanced TNM stage (III/IV) significantly correlated with increased NOS3 expression. CONCLUSIONS: NOS3 is expressed in refluxinduced lesions of the esophagus. Glandular metaplasia shows basal levels of NOS3 that significantly increase with malignant transformation and tumor progression. The role of free radicals in carcinogenesis is being actively studied.

scholarly journals The role of GluN1 activated nitric oxide synthase in a rat model of post-traumatic stress disorder

2016 ◽  
Vol 29 (2) ◽  
pp. 67
Author(s):  
Beycan Gözde Ayhan ◽  
Aslı Aykaç ◽  
Kutlay Gür ◽  
Banu Aydın ◽  
Ece Seçgin ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Rat Model ◽  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Stress Disorder ◽  
Post Traumatic Stress ◽  
Post Traumatic ◽  
Oxide Synthase
Sign in / Sign up

Export Citation Format

Share Document