Profiles of chemically-induced tumors in rodents: quantitative relationships

1998 ◽  
Vol 421 (1) ◽  
pp. 93-107 ◽  
Author(s):  
Romualdo Benigni ◽  
Anna Pino
Keyword(s):  
Chemically Induced ◽  
Induced Tumors

TAp73 opposes tumor angiogenesis by promoting hypoxia-inducible factor 1α degradation

2020 ◽  
Author(s):  
Lungwani Muungo
Keyword(s):  
Cancer Progression ◽  
Hypoxia Inducible Factor ◽  
Tumor Hypoxia ◽  
Human Lung Cancer ◽  
Regulatory Subunit ◽  
Patients With Cancer ◽  
Hypoxia Inducible Factor 1 ◽  
Chemically Induced ◽  
Induced Tumors ◽  
Patient Prognosis

Tumor hypoxia and hypoxia-inducible factor 1 (HIF-1) activationare associated with cancer progression. Here, we demonstrate thatthe transcription factor TAp73 opposes HIF-1 activity through anontranscriptional mechanism, thus affecting tumor angiogenesis.TAp73-deficient mice have an increased incidence of spontaneousand chemically induced tumors that also display enhanced vascularization.Mechanistically, TAp73 interacts with the regulatory subunit(α) of HIF-1 and recruits mouse double minute 2 homolog intothe protein complex, thus promoting HIF-1α polyubiquitination andconsequent proteasomal degradation in an oxygen-independentmanner. In human lung cancer datasets, TAp73 strongly predictsgood patient prognosis, and its expression is associated with lowHIF-1 activation and angiogenesis. Our findings, supported by invivo and clinical evidence, demonstrate a mechanism for oxygenindependentHIF-1 regulation, which has important implicationsfor individualizing therapies in patients with cancer.

Immunotherapy of Chemically-Induced Tumors in the Hamster Cheek Pouch with Dinitrochlorobenzene

1978 ◽  
Vol 57 (4) ◽  
pp. 625-630 ◽  
Author(s):  
Martin Marshack ◽  
Patrick Toto ◽  
Ronald Kerman
Keyword(s):  
Defense Mechanisms ◽  
Immune Defense ◽  
Lymphoid Cells ◽  
Cheek Pouch ◽  
Hamster Cheek Pouch ◽  
Time Intervals ◽  
Tumor Induction ◽  
Chemically Induced ◽  
Induced Tumors ◽  
Tumor Area

Immune stimulation with an agent such as dinitrochlorobenzene (DNCB) may delay chemcal carcinogenesis. Dimethylbenzanthracene (DMBA) was used to chemically induce tumors in the hamster buccal pouch. Hamsters were studied for the effect of DNCB sensitization in the buccal pouch prior to or after DMBA tumor induction. At appropriate time intervals the hamsters were sacrificed and each cheek pouch was examined histologically for the development of DMBA-induced tumors and for the presence of lymphoid cells infiltrating the tumor site. The results show that DNCB immunotherapy or immunoprophylaxis prior to or following DMBA tumor induction can alter the type of tumor produced and stimulate an infiltration of lymphoid cells into the tumor area probably invoking immune defense mechanisms.

scholarly journals Impact of TCR Diversity on the Development of Transplanted or Chemically Induced Tumors

2019 ◽  
Vol 8 (2) ◽  
pp. 192-202 ◽  
Author(s):  
Karin Schreiber ◽  
Theodore G. Karrison ◽  
Steven P. Wolf ◽  
Kazuma Kiyotani ◽  
Madeline Steiner ◽  
...  
Keyword(s):  
Chemically Induced ◽  
Induced Tumors ◽  
Tcr Diversity

scholarly journals Glutathione S-Transferases in Chemically Induced Tumors

1984 ◽  
Vol 12 (4) ◽  
pp. 344-349
Author(s):  
Pavel Kraus ◽  
Rolf Schulte-Hermann ◽  
Irene Timmermann-Trosiener ◽  
Jöurg Schuppler
Keyword(s):  
Chemically Induced ◽  
Induced Tumors ◽  
Glutathione S Transferases

Evaluation of mutant frequencies of chemically induced tumors and normal tissues in ?/cII transgenic mice

2005 ◽  
Vol 45 (1) ◽  
pp. 17-35 ◽  
Author(s):  
Jon C. Mirsalis ◽  
Julie A. Shimon ◽  
Alphonso Johnson ◽  
David Fairchild ◽  
Nathan Kanazawa ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Normal Tissues ◽  
Chemically Induced ◽  
Induced Tumors

Relation Between Latent Period and Growth Rate in Chemically Induced Tumors

1939 ◽  
Vol 42 (2) ◽  
pp. 374-377 ◽  
Author(s):  
A. M. Brues ◽  
A. E. Weiner ◽  
H. B. Andervont
Keyword(s):  
Growth Rate ◽  
Latent Period ◽  
Chemically Induced ◽  
Induced Tumors
Sign in / Sign up

Export Citation Format

Share Document