Two mutations in the multidrug-resistance gene homologue of Plasmodium falciparum, pfmdr1, are not useful predictors of in-vivo or in-vitro chloroquine resistance in southern Africa

1999 ◽  
Vol 93 (3) ◽  
pp. 300-302 ◽  
Author(s):  
K.R.G. McCutcheon ◽  
J.A. Freese ◽  
J.A. Frean ◽  
B.L. Sharp ◽  
M.B. Markus
Keyword(s):  
Plasmodium Falciparum ◽  
Multidrug Resistance ◽  
Resistance Gene ◽  
Southern Africa ◽  
Chloroquine Resistance ◽  
Multidrug Resistance Gene ◽  
Resistance Gene Homologue ◽  
Gene Homologue

Transcripts of the multidrug resistance genes in chloroquine-sensitive and chloroquine-resistant Plasmodium falciparum

Parasitology ◽  
1993 ◽  
Vol 106 (2) ◽  
pp. 107-115 ◽  
Author(s):  
R. M. Ekong ◽  
K. J. H. Robson ◽  
D. A. Baker ◽  
D. C. Warhurst
Keyword(s):  
Plasmodium Falciparum ◽  
Multidrug Resistance ◽  
Resistance Gene ◽  
Resistance Genes ◽  
Copy Number ◽  
Chloroquine Resistance ◽  
Multidrug Resistance Gene ◽  
Genetic Cross ◽  
Multidrug Resistance Genes

SUMMARYHomologues of the mammalian multidrug resistance gene have been identified in isolates and clones of Plasmodium falciparum and designated pfmdr1 and pfmdr2. Mutations in pfmdr1 have been associated with chloroquine resistance but confirmation could not be obtained in a genetic cross. We have examined the copy number and expression of pfmdr1 and pfmdr2 in chloroquine-sensitive and -resistant P. falciparum and have found no relationship between the copy number of either gene and chloroquine resistance. However, a marked correlation was seen between levels of mRNA transcribed for each gene and chloroquine resistance. Two transcripts of pfmdr1 were detected, and in the asexual blood cycle an 8 kb transcript appeared first, followed by the appearance of a 7 kb species.

Several alleles of the multidrug-resistance gene are closely linked to chloroquine resistance in Plasmodium falciparum

Nature ◽  
1990 ◽  
Vol 345 (6272) ◽  
pp. 255-258 ◽  
Author(s):  
S. J. Foote ◽  
D. E. Kyle ◽  
R. K. Martin ◽  
A. M. J. Oduola ◽  
K. Forsyth ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Multidrug Resistance ◽  
Resistance Gene ◽  
Chloroquine Resistance ◽  
Multidrug Resistance Gene

Selection of Keratinocytes Transduced with the Multidrug Resistance Gene in an in Vitro Skin Model Presents a Strategy for Enhancing Gene Expression in Vivo

1999 ◽  
Vol 10 (17) ◽  
pp. 2811-2821 ◽  
Author(s):  
Wolfgang Pfutzner ◽  
Ulrich R. Hengge ◽  
Mohamed A. Joari ◽  
Ruth-Ann Foster ◽  
Jonathan C. Vogel
Keyword(s):  
Gene Expression ◽  
Multidrug Resistance ◽  
Resistance Gene ◽  
Skin Model ◽  
Multidrug Resistance Gene ◽  
Selection Of ◽  
In Vitro Skin Model

scholarly journals Plasmodium falciparum Multidrug Resistance Proteins (pfMRPs)

2021 ◽  
Vol 12 ◽  
Author(s):  
José Pedro Gil ◽  
Cláudia Fançony
Keyword(s):  
Drug Resistance ◽  
Plasmodium Falciparum ◽  
Multidrug Resistance ◽  
Multi Drug Resistance ◽  
Multidrug Resistance Proteins ◽  
Resistance Proteins ◽  
Diverse Groups ◽  
Endogenous Substances

The capacity of the lethal Plasmodium falciparum parasite to develop resistance against anti-malarial drugs represents a central challenge in the global control and elimination of malaria. Historically, the action of drug transporters is known to play a pivotal role in the capacity of the parasite to evade drug action. MRPs (Multidrug Resistance Protein) are known in many phylogenetically diverse groups to be related to drug resistance by being able to handle a large range of substrates, including important endogenous substances as glutathione and its conjugates. P. falciparum MRPs are associated with in vivo and in vitro altered drug response, and might be important factors for the development of multi-drug resistance phenotypes, a latent possibility in the present, and future, combination therapy environment. Information on P. falciparum MRPs is scattered in the literature, with no specialized review available. We herein address this issue by reviewing the present state of knowledge.

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