Expression of epstein-barr virus in carcinomas of major salivary glands: A strong association with lymphoepithelioma-like carcinoma

1996 ◽  
Vol 27 (3) ◽  
pp. 258-262 ◽  
Author(s):  
Chien-chen Tsai ◽  
Chi-long Chen ◽  
Hey-chi Hsu
Keyword(s):  
Salivary Glands ◽  
Epstein Barr Virus ◽  
Strong Association ◽  
Barr Virus ◽  
Major Salivary Glands ◽  
Epstein Barr

Undifferentiated Carcinoma with Lymphoid Stroma of the Major Salivary Glands

1990 ◽  
Vol 99 (3) ◽  
pp. 236-238 ◽  
Author(s):  
Karen R. Cleary ◽  
John G. Batsakis
Keyword(s):  
Salivary Glands ◽  
Epstein Barr Virus ◽  
Undifferentiated Carcinoma ◽  
Response To Therapy ◽  
Lymphoepithelial Carcinoma ◽  
Lymphoepithelial Lesion ◽  
Barr Virus ◽  
Lymphoid Stroma ◽  
Major Salivary Glands ◽  
Epstein Barr

Undifferentiated carcinoma with lymphoid stroma or lymphoepithelial carcinoma of the major salivary glands is a demographically and histopathologically unique malignancy. Although whites may have the disease, it is preponderantly a carcinoma of North American Eskimos and native Greenlanders. The carcinoma shares many features with undifferentiated nasopharyngeal carcinomas, from which it must be distinguished: histologic appearance, putative relationship with Epstein-Barr virus, predilection for mongoloid races, and response to therapy. In some cases, the carcinoma appears to have evolved from a lymphoepithelial lesion.

Epstein-Barr Virus–Associated Lymphoepithelioma-like Gastric Carcinoma

2008 ◽  
Vol 132 (4) ◽  
pp. 706-709
Author(s):  
Chaturika Harshini Pavithra Herath ◽  
Runjan Chetty
Keyword(s):  
Polymerase Chain Reaction ◽  
Gastric Carcinoma ◽  
Microsatellite Instability ◽  
Epstein Barr Virus ◽  
Strong Association ◽  
Polymerase Chain Reaction Analysis ◽  
Chain Reaction ◽  
Barr Virus ◽  
Polymerase Chain ◽  
Epstein Barr

Abstract This article provides an overview of the pathology of Epstein-Barr virus (EBV)–associated lymphoepithelioma-like gastric carcinoma, highlighting its unique morphology and clinical features. Lymphoepithelioma-like gastric carcinoma is a rare neoplasm of the stomach with a better prognosis than conventional adenocarcinoma. Most lymphoepithelioma-like gastric carcinomas are associated with EBV infection, while a subset is associated with microsatellite instability. Even though there is a very strong association with EBV, its exact role in carcinogenesis still remains to be elucidated in those cancers that harbor EBV. Distinctive histology and demonstration of EBV using in situ hybridization, polymerase chain reaction, or Southern blotting and immunohistochemistry for the DNA mismatch repair genes or polymerase chain reaction analysis of microsatellite loci to assess microsatellite instability helps to make the diagnosis.

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