Increasing evidence that Epstein-Barr virus may be involved in the pathogenesis of undifferentiated carcinoma of the salivary glands

1996 ◽  
Vol 27 (12) ◽  
pp. 1381 ◽  
Author(s):  
Oreste Gallo
Keyword(s):  
Salivary Glands ◽  
Epstein Barr Virus ◽  
Undifferentiated Carcinoma ◽  
Barr Virus ◽  
Epstein Barr

Undifferentiated Carcinoma with Lymphoid Stroma of the Major Salivary Glands

1990 ◽  
Vol 99 (3) ◽  
pp. 236-238 ◽  
Author(s):  
Karen R. Cleary ◽  
John G. Batsakis
Keyword(s):  
Salivary Glands ◽  
Epstein Barr Virus ◽  
Undifferentiated Carcinoma ◽  
Response To Therapy ◽  
Lymphoepithelial Carcinoma ◽  
Lymphoepithelial Lesion ◽  
Barr Virus ◽  
Lymphoid Stroma ◽  
Major Salivary Glands ◽  
Epstein Barr

Undifferentiated carcinoma with lymphoid stroma or lymphoepithelial carcinoma of the major salivary glands is a demographically and histopathologically unique malignancy. Although whites may have the disease, it is preponderantly a carcinoma of North American Eskimos and native Greenlanders. The carcinoma shares many features with undifferentiated nasopharyngeal carcinomas, from which it must be distinguished: histologic appearance, putative relationship with Epstein-Barr virus, predilection for mongoloid races, and response to therapy. In some cases, the carcinoma appears to have evolved from a lymphoepithelial lesion.

scholarly journals Histological and Electron Microscopic Studies of Endemic Ethmoidal Carcinomas in Cattle

1979 ◽  
Vol 16 (2) ◽  
pp. 180-190 ◽  
Author(s):  
A. Pospischil ◽  
T. Haenichen ◽  
H. Schaeffler
Keyword(s):  
Epstein Barr Virus ◽  
Undifferentiated Carcinoma ◽  
Olfactory Mucosa ◽  
Lymphoid Cells ◽  
Electron Microscopic ◽  
Barr Virus ◽  
Human Nasopharyngeal Carcinoma ◽  
Microscopic Studies ◽  
Epstein Barr ◽  
Tumor Types

In five cases of endemic ethmoidal carcinoma in cattle from the Dominican Republic three tumor types could be classified: undifferentiated carcinoma (3), adenocarcinoma (1), and squamous cell carcinoma (1). Electron microscopy showed that the tumor cells in undifferentiated carcinomas closely resembled the cells of the normal olfactory mucosa. This was especially true for the dark cells of Bowman's gland. Ultrastructurally, the lymphoid cells of the undifferentiated bovine carcinoma resembled the lymphoid cells of human nasopharyngeal carcinoma being closely associated with Epstein-Barr Virus. This and epidemiological observations suggested a viral cause of endemic ethmoidal carcinoma.

Clinical value of Epstein–Barr virus DNA levels in peripheral blood samples of Italian patients with Undifferentiated Carcinoma of Nasopharyngeal Type

2006 ◽  
Vol 233 (2) ◽  
pp. 247-254 ◽  
Author(s):  
Maria Teresa Bortolin ◽  
Chiara Pratesi ◽  
Riccardo Dolcetti ◽  
Ettore Bidoli ◽  
Emanuela Vaccher ◽  
...  
Keyword(s):  
Peripheral Blood ◽  
Epstein Barr Virus ◽  
Undifferentiated Carcinoma ◽  
Clinical Value ◽  
Blood Samples ◽  
Barr Virus ◽  
Epstein Barr

Absence of Epstein-Barr virus encoded RNA and latent membrane protein (LMP1) in salivary gland neoplasms

1999 ◽  
Vol 113 (10) ◽  
pp. 906-908 ◽  
Author(s):  
A. M. Pollock ◽  
M. Toner ◽  
M. McMenamin ◽  
J. Walker ◽  
C. I. Timon
Keyword(s):  
Salivary Gland ◽  
Membrane Protein ◽  
Epstein Barr Virus ◽  
Undifferentiated Carcinoma ◽  
Latent Membrane Protein ◽  
Positive Signal ◽  
Salivary Gland Tumours ◽  
Barr Virus ◽  
Epstein Barr

AbstractA series of 55 (42 benign and 13 malignant) salivary gland tumours were investigated by immunohistochemistry, to detect Epstein-Barr virus (EBV) latent membrane protein (LMP1) and byin situhybridization for EBV-encoded RNA. Non-neoplastic gland from all the patients with tumours and 15 control glands were also examined. All cases, both neoplastic and non-neoplastic were negative for LMP1 and failed to show any positive signal byin situhybridization for EBV RNA. One undifferentiated carcinoma from a European patient was included in the group. These results confirm previous reports of an ethnic association between EBV and undifferentiated carcinomas of the salivary gland. They do not support an aetiological role for EBV in other salivary gland tumours.

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