Ablation of renal tumors in a rabbit model with interstitial saline-augmented radiofrequency energy: preliminary report of a new technology

To construct the tissue engineering urethral material that is closest to the normal urethral structure in the true sense in vitro. Abdominal ADSC from a 2-month-old New Zealand white rabbit was extracted and directly compounded with non-woven polyglycolic acid (PGA) (control group) to induce the differentiation of myoblasts and epithelial-like cells in vitro and shaped into urethral structure lumen Observation group); After Gd chelating protein nano-labeling and VEGF-loaded sustained release, the rabbit model of a long urethral defect was replanted and cultured for 4 weeks, 8 weeks and 12 weeks, respectively. There was no difference in urinary tract patency rate, urinary tract infection, and renal dysfunction rate between the two groups (P > 0.05). The urine flow rate in the observation group was significantly higher than that in the control group, and the residual volume decreased (P < 0.05). The blood vessel density and CD31 percentage in the observation group increased (P < 0.05). Compared with the conventional ADSC directly in contact with the composite material to construct the urethra, in vitro induction of ADSC to myoblasts and epithelial-like cells respectively, and then use the cell membrane technology to build a tissue engineering urethral material that is closest to the normal urethral structure in the true sense, and loaded with VEGF Loop release technology can significantly improve urodynamic functions, optimize tissue engineering urethral structure and vascularization, and is expected to become a new technology for constructing new tissue engineering urethral materials.

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Retroperitoneoscopy-Assisted Cryoablation of Renal Tumors Using Multiple 1.5mm Ultrathin Cryoprobes: A Preliminary Report

European Urology ◽

10.1016/j.eururo.2004.12.024 ◽

2005 ◽

Vol 47 (4) ◽

pp. 474-479 ◽

Cited By ~ 28

Author(s):

Alexander Bachmann ◽

Tullio Sulser ◽

Christian Jayet ◽

Stephen Wyler ◽

Robin Ruszat ◽

...

Keyword(s):

Preliminary Report ◽

Renal Tumors

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Testing of a Novel Percutaneous Temporary Aortic Valve in a Rabbit Model of Acute Severe Aortic Regurgitation: An Experimental Study

The International Journal of Artificial Organs ◽

10.5301/ijao.5000596 ◽

2017 ◽

Vol 40 (7) ◽

pp. 361-365

Author(s):

Paul C. Ho

Keyword(s):

Aortic Valve ◽

Aortic Regurgitation ◽

New Technology ◽

Rabbit Model ◽

Hemodynamic Instability ◽

Survival Times ◽

Device Management ◽

Severe Aortic Regurgitation ◽

Body Weights ◽

The Mean

Purpose Device management of hemodynamic instability due to acute aortic regurgitation is not available. A novel, catheter-based, temporary aortic valve (TAV) has been in development. Early prototypes (balloon-based TAV) have undergone proof-of-concept studies in mathematical, bench and animal models. The redesigned membrane-based TAV prototype is evaluated in a rabbit model of acute severe aortic regurgitation. Methods Acute aortic regurgitation was simulated by deploying a self-expanding endovascular stent across the aortic annulus. Eight rabbits of body weights ranging 4.9–5.4 kg were randomly assigned to two groups: those received additional hemodynamic support with the TAV prototype immediately after aortic regurgitation was induced versus no TAV support. The survival times of the two groups were compared. Results Comparing the groups with TAV versus without TAV, the mean body weights were similar: 4.99 ± 0.06 vs. 5.10 ± 0.22 kg (p = 0.71). The mean stent sizes used to create acute aortic regurgitation were similar: 6.25 ± 0.50 vs. 6.75 ± 0.50 mm, respectively (p = 0.53). The mean survival times also did not differ significantly: 21.00 ± 15.41 vs. 8.25 ± 2.75 minutes, respectively (p = 0.45). A slight trend appeared to be in favor of longer survival in the TAV supported group. Conclusions In a rabbit model of acute massive aortic regurgitation, the use of the TAV support prototype did not hasten the animals’ death, but rather survival may be enhanced by the use of the device. Future studies specifically designed to evaluate the efficacy of the TAV catheter can be valuable in this new technology.

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Editorial Comment to Progression of hypertension after partial nephrectomy in patients with renal tumors: A preliminary report

International Journal of Urology ◽

10.1111/iju.12815 ◽

2015 ◽

Vol 22 (8) ◽

pp. 798-799

Author(s):

Toshihiko Sakurai

Keyword(s):

Editorial Comment ◽

Partial Nephrectomy ◽

Preliminary Report ◽

Renal Tumors

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Validation of a rabbit model of irradiated bone healing: preliminary report

Journal of Oral Medicine and Oral Surgery ◽

10.1051/mbcb/2020012 ◽

2020 ◽

Vol 26 (2) ◽

pp. 24

Author(s):

Aline Desoutter ◽

Stephan Langonnet ◽

Sophie Deneuve ◽

Jean-Christophe Bera ◽

Anne-Gaëlle Chaux-Bodard

Keyword(s):

Bone Mineral Density ◽

Pilot Study ◽

Bone Mineral ◽

Bone Healing ◽

Preliminary Report ◽

Rabbit Model ◽

External Radiotherapy ◽

Mineral Density ◽

Trabecular Separation ◽

Trabecular Number

Introduction: External radiotherapy can lead to severe bone alteration. The aim of this pilot study was to validate a model for assessment of postextractional bone healing in the irradiated rabbit mandible. Material and method: The radiation protocol consisted of 5 sessions delivering 8.5 Gy each. Surgery was performed immediately after completion of radiotherapy. Sacrifices were performed from Day 0 to Day 42. Results: The bone mineral density and the trabecular number were decreased after radiotherapy whereas trabecular separation increased. The main differences between irradiated and non-irradiated rabbits were observed at Day 28 and 42. Discussion: Radiation seems to cause a delay in bone healing. It decreases bone quality and bone mineral density. Five sessions seem to be a valuable compromise between tissues effect and feasibility of the experiment. Conclusion: This model seems to be valuable for evaluating postextractional bone healing in the irradiated rabbit mandible.

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