scholarly journals Validation of a rabbit model of irradiated bone healing: preliminary report

2020 ◽  
Vol 26 (2) ◽  
pp. 24
Author(s):  
Aline Desoutter ◽  
Stephan Langonnet ◽  
Sophie Deneuve ◽  
Jean-Christophe Bera ◽  
Anne-Gaëlle Chaux-Bodard

Introduction: External radiotherapy can lead to severe bone alteration. The aim of this pilot study was to validate a model for assessment of postextractional bone healing in the irradiated rabbit mandible. Material and method: The radiation protocol consisted of 5 sessions delivering 8.5 Gy each. Surgery was performed immediately after completion of radiotherapy. Sacrifices were performed from Day 0 to Day 42. Results: The bone mineral density and the trabecular number were decreased after radiotherapy whereas trabecular separation increased. The main differences between irradiated and non-irradiated rabbits were observed at Day 28 and 42. Discussion: Radiation seems to cause a delay in bone healing. It decreases bone quality and bone mineral density. Five sessions seem to be a valuable compromise between tissues effect and feasibility of the experiment. Conclusion: This model seems to be valuable for evaluating postextractional bone healing in the irradiated rabbit mandible.

2021 ◽  
Vol 120 ◽  
pp. 111775
Author(s):  
Gustavo Antonio Correa Momesso ◽  
Tarik Ocon Braga Polo ◽  
William Phillip Pereira da Silva ◽  
Stéfany Barbosa ◽  
Gileade P. Freitas ◽  
...  

Gene ◽  
2013 ◽  
Vol 526 (2) ◽  
pp. 295-298 ◽  
Author(s):  
Sophie Brunner-Ziegler ◽  
Georgiana-Aura Giurgea ◽  
Raute Sunder-Plassmann ◽  
Alexandra Hammer ◽  
Christian Margeta ◽  
...  

2003 ◽  
Vol 8 (6) ◽  
pp. 772-776 ◽  
Author(s):  
Jukkas Kettunen ◽  
Heikki Kröger ◽  
Mark Bowditch ◽  
Jaakko Joukainen ◽  
Olavi Suomalainen

2015 ◽  
Vol 8 (6) ◽  
pp. 526-531
Author(s):  
S. Hadhrami ◽  
J. Sulaimi ◽  
D. Kindi ◽  
O. Elshafie ◽  
S. Hussien ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document