Low doses of AMPA exert anticonvulsant effects on pentylenetetrazol-kindled seizures

2001 ◽  
Vol 70 (2-3) ◽  
pp. 421-426 ◽  
Author(s):  
Axel Becker ◽  
Gisela Grecksch ◽  
Helmut Schroeder
Keyword(s):  
Low Doses ◽  
Kindled Seizures ◽  
Anticonvulsant Effects

The anticonvulsant effects of progesterone and its metabolites on amygdala-kindled seizures in male rats

2006 ◽  
Vol 1101 (1) ◽  
pp. 110-116 ◽  
Author(s):  
Deborah Lonsdale ◽  
Kirk Nylen ◽  
W. McIntyre Burnham
Keyword(s):  
Male Rats ◽  
Kindled Seizures ◽  
Anticonvulsant Effects

scholarly journals The Anticonvulsant Effects of Vitamin E: A Further Evaluation

1992 ◽  
Vol 19 (2) ◽  
pp. 201-203 ◽  
Author(s):  
Sheldon L. Levy ◽  
W.M. Burnham ◽  
A. Bishai ◽  
Paul A. Hwang
Keyword(s):  
Vitamin E ◽  
Partial Epilepsy ◽  
Maximal Electroshock ◽  
Partial Seizures ◽  
Ferrous Chloride ◽  
Complex Partial Seizures ◽  
Complex Partial Epilepsy ◽  
Kindled Seizures ◽  
Standard Animal ◽  
Anticonvulsant Effects

ABSTRACT:Vitamin E (d-α-tocopherol) has proven to be a useful adjunct to anticonvulsant drugs in clinical studies. Improvement has occurred even in patients with complex partial seizures, which are often resistant to drug therapy. In animals, vitamin E is effective against ferrous chloride seizures, hyperbaric oxygen seizures and penicillin-induced seizures. It has failed, however, to show anticonvulsant effects in the standard animal models used for drug screening – the maximal electroshock and threshold pentylenetetrazol tests. The present experiments were designed to further explore the anti-epileptic actions of vitamin E in animals. Three models related to complex partial epilepsy were used: 1) the development of amygdala-kindled seizures; 2) the development of electrically-induced status in kindled animals; and 3) the development of kainic-acid seizures. Vitamin E failed to produce significant effects in any of the models.

Anticonvulsant effect of A1 but not A2A adenosine receptors of piriform cortex in amygdala-kindled rats

2007 ◽  
Vol 85 (6) ◽  
pp. 606-612 ◽  
Author(s):  
Mohammad Ebrahim Rezvani ◽  
Javad Mirnajafi-Zadeh ◽  
Yaghoub Fathollahi ◽  
Mohammad Reza Palizvan
Keyword(s):  
Electrical Stimulation ◽  
Adenosine Receptors ◽  
Piriform Cortex ◽  
Anticonvulsant Effect ◽  
Seizure Duration ◽  
A2a Adenosine Receptors ◽  
Stage 4 ◽  
Kindled Seizures ◽  
Anticonvulsant Effects ◽  
Stimulation Of

In this study, the effect of A1 and A2A adenosine receptor activity of the piriform cortex (PC) on amygdala-kindled seizures was investigated in rats. Animals were kindled by daily electrical stimulation of the amygdala. In fully kindled rats, N6-cyclohexyladenosine (CHA, a selective A1 agonist), 8-cyclopentyl-1,3-dimethylxanthine (CPT, a selective A1 antagonist), CGS21680 hydrochloride (CGS, a selective A2A agonist), and ZM241385 (ZM, a selective A2A antagonist) were microinjected bilaterally into the PC. Rats were stimulated 5 min post-drug microinjection and seizure parameters were measured. Results showed that intra-PC CHA (10 and 100 μmol/L) decreased the duration of both afterdischarge and stage 5 seizure and significantly increased the latency to stage 4 seizure. Intra-PC CPT increased afterdischarge and stage 5 seizure duration at the dose of 20 μmol/L. The anticonvulsant effect of CHA (100 μmol/L) was eliminated by CPT (10 μmol/L) pretreatment. On the other hand, neither intra-PC CGS nor ZM had a significant effect on kindled seizures. These results suggest that activity of A1, but not A2A, receptors of the PC have anticonvulsant effects on kindled seizures elicited from electrical stimulation of the amygdala.

scholarly journals Vigabatrin in Low Doses Selectively Suppresses the Clonic Component of Audiogenically Kindled Seizures in Rats

Epilepsia ◽  
2005 ◽  
Vol 46 (6) ◽  
pp. 800-810 ◽  
Author(s):  
Ludmilla V. Vinogradova ◽  
Galina D. Kuznetsova ◽  
Alla B. Shatskova ◽  
Clementina M. van Rijn
Keyword(s):  
Low Doses ◽  
Kindled Seizures

Potent and long-lasting anticonvulsant effects of 1-naphthylacetyl spermine, an analogue of Joro spider toxin, against amygdaloid kindled seizures in rats

1996 ◽  
Vol 706 (1) ◽  
pp. 173-176 ◽  
Author(s):  
Akira Takazawa ◽  
Osamu Yamazaki ◽  
Hirohiko Kanai ◽  
Nobuya Ishida ◽  
Nobumasa Kato ◽  
...  
Keyword(s):  
Spider Toxin ◽  
Kindled Seizures ◽  
Anticonvulsant Effects

Anticonvulsant effects of adenosine analogues on amygdaloid-kindled seizures in rats

1984 ◽  
Vol 46 (3) ◽  
pp. 317-322 ◽  
Author(s):  
Robin A. Barraco ◽  
Thomas H. Swanson ◽  
John W. Phillis ◽  
Robert F. Berman
Keyword(s):  
Adenosine Analogues ◽  
Kindled Seizures ◽  
Anticonvulsant Effects

The effect of taurine on kindled seizures in the rat

1978 ◽  
Vol 56 (3) ◽  
pp. 497-500 ◽  
Author(s):  
W. M. Burnham ◽  
P. Albright ◽  
R. J. Racine
Keyword(s):  
Amino Acid ◽  
Anticonvulsant Drugs ◽  
Threshold Levels ◽  
Kindled Seizures ◽  
The Brain ◽  
Anticonvulsant Effects ◽  
Near Threshold

Recently, it has been reported that taurine, an amino acid with anticonvulsant properties, does not suppress experimental seizures generated by the 'kindling' technique. This finding seems somewhat paradoxical since taurine antagonizes other sorts of experimental convulsion and since kindled seizures are easily suppressed by other anticonvulsant drugs. Further tests were therefore conducted during which taurine's anticonvulsant effects were assessed: (1) when kindling stimulation was dropped to near-threshold levels; (2) when cortical as well as limbic kindled foci were stimulated; (3) when developing as well as fully kindled seizures were involved; and (4) when taurine was introduced directly into the ventricles of the brain. Even in these tests which were specifically designed to favour the appearance of anticonvulsant effects, no taurine antagonism of kindled seizures was found.

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