scholarly journals Bilateral lower limb weakness in acute severe ulcerative colitis

The Lancet ◽  
2016 ◽  
Vol 388 (10039) ◽  
pp. 101-102 ◽  
Author(s):  
Ruairi W Lynch ◽  
Timothy Soane ◽  
Rod Gibson ◽  
Suvankar Pal ◽  
Charlie W Lees
Keyword(s):  
Ulcerative Colitis ◽  
Lower Limb ◽  
Limb Weakness ◽  
Severe Ulcerative Colitis ◽  
Lower Limb Weakness ◽  
Bilateral Lower Limb

scholarly journals Bilateral lower limb weakness: a cerebrovascular consequence of covid-19 or a complication associated with it?

2020 ◽  
Vol 15 (5) ◽  
pp. 901-905 ◽  
Author(s):  
J. B. Morjaria ◽  
F. Omar ◽  
R. Polosa ◽  
G. Gulli ◽  
P. U. Dalal ◽  
...  
Keyword(s):  
Lower Limb ◽  
Limb Weakness ◽  
Lower Limb Weakness ◽  
Bilateral Lower Limb

scholarly journals Primary spinal peripheral primitive neuroectodermal tumor with acute presentation: A case report and review of literature

2019 ◽  
Vol 10 (3) ◽  
pp. 59-61
Author(s):  
Abta Bachchan ◽  
Kaushik Roy ◽  
Suniti Kumar Saha ◽  
Debajyoti Pathak ◽  
Partha Ghosh ◽  
...  
Keyword(s):  
Lower Limb ◽  
Bowel Dysfunction ◽  
Review Of Literature ◽  
Peripheral Primitive Neuroectodermal Tumor ◽  
Thoracic Region ◽  
Radiological Findings ◽  
Limb Weakness ◽  
Lower Limb Weakness ◽  
Neuroectodermal Tumors ◽  
Bilateral Lower Limb

Primary spinal primitive neuroectodermal tumors (PNET) is a rare occurrence and carries a poor prognosis. A 13-year old female patient acutely presented with pain in the thoracic region, bilateral lower limb weakness, bladder and bowel dysfunction. Clinically paraplegia with truncal weakness, lower limb deep tendon reflexes of both side were absent and planter reflexes equivocal bilaterally. Preoperative MRI of thoracic spine revealed D4-D6 extradural SOL. A D4-D5 Laminectomy and left Cortico transversectomy done. Pathological findings were consistent with PNET. The clinical, histopathological, and radiological findings of the patient are presented.

scholarly journals Spontaneous spinal epidural hematoma: a case report

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Ooi Chin Sheng ◽  
Ren-Chieh Wu ◽  
I-Hsin Chang
Keyword(s):  
Lower Limb ◽  
Epidural Hematoma ◽  
Lower Limbs ◽  
Spinal Epidural Hematoma ◽  
Limb Weakness ◽  
Female Ratio ◽  
Spontaneous Spinal Epidural Hematoma ◽  
Lower Limb Weakness ◽  
Bilateral Lower Limb ◽  
Spinal Epidural

Abstract Background Spinal epidural hematomas usually occur under certain conditions; they rarely occur spontaneously. The prevalence of spontaneous spinal epidural hematoma is ~ 0.1 per 100,000, and the male-to-female ratio is approximately 1.4 to 1. Herein, we describe a rare case of spontaneous spinal epidural hematoma. Case presentation A 63-year-old Taiwanese woman, with underlying hypertension, anemia, and a history of cardiovascular accident without sequela, was admitted to our emergency department with a chief complaint of sudden bilateral weakness in the lower limbs. Magnetic resonance imaging revealed a spontaneous epidural hematoma. The patient underwent emergency surgery to remove the epidural hematoma and laminectomy for decompression. The bilateral lower limb weakness was alleviated immediately after the surgery. Conclusion In patients with no risk factors related to spinal epidural hematoma, symptoms of bilateral lower limb weakness must be investigated carefully because this condition may occur spontaneously.

scholarly journals Familial Hemophagocytic Lymphohistiocytosis Secondary to PRF1 Mutation

2021 ◽  
Vol 2021 ◽  
pp. 1-5
Author(s):  
Albaraa T. Alfaraidi ◽  
Abdulaziz A. Alqarni ◽  
Mohammed T. Aqeel ◽  
Turki A. Albalawi ◽  
Ahmed S. Hejazi
Keyword(s):  
Lower Limb ◽  
Hemophagocytic Lymphohistiocytosis ◽  
Multiorgan Failure ◽  
Unknown Origin ◽  
High Fever ◽  
Intrathecal Methotrexate ◽  
Limb Weakness ◽  
Lower Limb Weakness ◽  
Bilateral Lower Limb ◽  
The Brain

Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening hyperinflammatory syndrome that causes systemic inflammation which can progress to multiorgan failure and death. Symptoms and signs commonly seen in HLH include high fever, hepatosplenomegaly, pancytopenia, and hypertriglyceridemia. This report describes the 8-month clinical course of a 17-year-old male with G6PD deficiency who presented with intermittent high fever of unknown origin for 8 months accompanied by pancytopenia and bilateral lower limb weakness. A pathogenic homozygous missense mutation (c.1081A > T p.(Arg361Trp)) in the PRF1 gene was detected by whole exome sequencing (WES). The brain and the whole spine MRI showed leptomeningeal enhancement at different levels involving both the brain and the spine. Therefore, a diagnosis of familial HLH type 2 with CNS involvement was confirmed. Accordingly, treatment with dexamethasone, cyclosporin, and etoposide in addition to intrathecal methotrexate and hydrocortisone was given. The patient showed a dramatic response with significant neurological improvement of the bilateral lower limb weakness. Genetic analysis has helped the patient’s family with appropriate genetic counselling. This case highlights the importance of immediate treatment with immunosuppressants and the high clinical suspicion of physicians regarding HLH in areas where consanguinity is common.

scholarly journals Postpartum femoral neuropathy: managing the next pregnancy

2019 ◽  
Vol 12 (12) ◽  
pp. e232967 ◽  
Author(s):  
Cathy Rowland ◽  
Daniel Kane ◽  
Maeve Eogan
Keyword(s):  
Caesarean Section ◽  
Motor Function ◽  
Lower Limb ◽  
Elective Caesarean Section ◽  
Mode Of Delivery ◽  
Primiparous Woman ◽  
Limb Weakness ◽  
Femoral Neuropathy ◽  
Lower Limb Weakness ◽  
Spontaneous Labour

A 34-year-old primiparous woman presented in spontaneous labour and had an unassisted vaginal birth of a 3.5 kg infant. Postnatally, the patient experienced lower limb weakness and was unable to mobilise unassisted. A diagnosis of postpartum femoral neuropathy was made. Full recovery of normal motor function was not achieved until 5 months postpartum. She returned in her next pregnancy, seeking advice on how to avoid this complication from reoccurring. It was decided that an elective caesarean section was an appropriate mode of delivery, which she underwent at 39 weeks without complication and without recurrence of the femoral neuropathy.

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