Preparation and characterization of poly(lactic acid)–poly(ethylene glycol)–poly(lactic acid) (PLA–PEG–PLA) microspheres for controlled release of paclitaxel

Biomaterials ◽  
2003 ◽  
Vol 24 (27) ◽  
pp. 5037-5044 ◽  
Author(s):  
Gang Ruan ◽  
Si-Shen Feng
Keyword(s):  
Lactic Acid ◽  
Controlled Release ◽  
Ethylene Glycol ◽  
Poly Lactic Acid ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

scholarly journals Instantaneous Degelling Thermoresponsive Hydrogel

Gels ◽  
2021 ◽  
Vol 7 (4) ◽  
pp. 169
Author(s):  
Noam Y. Steinman ◽  
Abraham J. Domb
Keyword(s):  
Lactic Acid ◽  
Controlled Release ◽  
Ethylene Glycol ◽  
Disulfide Bonds ◽  
Hydrolytic Degradation ◽  
Poly Lactic Acid ◽  
Hydrolytic Cleavage ◽  
Poly Ethylene Glycol ◽  
Thermoresponsive Polymer ◽  
Poly Ethylene

Responsive polymeric hydrogels have found wide application in the clinic as injectable, biocompatible, and biodegradable materials capable of controlled release of therapeutics. In this article, we introduce a thermoresponsive polymer hydrogel bearing covalent disulfide bonds. The cold aqueous polymer solution forms a hydrogel upon heating to physiological temperatures and undergoes slow degradation by hydrolytic cleavage of ester bonds. The disulfide functionality allows for immediate reductive cleavage of the redox-sensitive bond embedded within the polymer structure, affording the option of instantaneous hydrogel collapse. Poly (ethylene glycol)-b-poly (lactic acid)-S-S-poly (lactic acid)-b-poly (ethylene glycol) (PEG-PLA-SS-PLA-PEG) copolymer was synthesized by grafting PEG to PLA-SS-PLA via urethane linkages. The aqueous solution of the resultant copolymer was a free-flowing solution at ambient temperatures and formed a hydrogel above 32 °C. The immediate collapsibility of the hydrogel was displayed via reaction with NaBH4 as a relatively strong reducing agent, yet stability was displayed even in glutathione solution, in which the polymer degraded slowly by hydrolytic degradation. The polymeric hydrogel is capable of either long-term or immediate degradation and thus represents an attractive candidate as a biocompatible material for the controlled release of drugs.

scholarly journals Characterization of poly (lactic acid) / poly (ethylene) glycol blends prepared for melt drawn spinning process

2019 ◽  
Vol 17 ◽  
pp. 889-897
Author(s):  
M.A. Nur Atiqah ◽  
I.S.S. Sharifah ◽  
F.B Yose ◽  
O. Maizatulnisa ◽  
S. Norhashimah
Keyword(s):  
Lactic Acid ◽  
Ethylene Glycol ◽  
Poly Lactic Acid ◽  
Poly Ethylene Glycol ◽  
Spinning Process ◽  
Poly Ethylene

The effect of poly(ethylene glycol) as plasticizer in blends of poly(lactic acid) and poly(butylene succinate)

2015 ◽  
Vol 133 (8) ◽  
pp. n/a-n/a ◽  
Author(s):  
Weraporn Pivsa-Art ◽  
Kazunori Fujii ◽  
Keiichiro Nomura ◽  
Yuji Aso ◽  
Hitomi Ohara ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Ethylene Glycol ◽  
Poly Lactic Acid ◽  
Poly Ethylene Glycol ◽  
Butylene Succinate ◽  
Poly Ethylene
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