Transient receptor potential (TRP) channels as potential drug targets in respiratory disease

Cell Calcium ◽  
2003 ◽  
Vol 33 (5-6) ◽  
pp. 551-558 ◽  
Author(s):  
Su Li ◽  
John Westwick ◽  
Chris Poll
Keyword(s):  
Respiratory Disease ◽  
Drug Targets ◽  
Transient Receptor Potential ◽  
Trp Channels ◽  
Receptor Potential ◽  
Potential Drug ◽  
Transient Receptor ◽  
Potential Drug Targets

scholarly journals Evidence for Transient Receptor Potential (TRP) Channel Contribution to Arthritis Pain and Pathogenesis

2018 ◽  
Vol 11 (4) ◽  
pp. 105 ◽  
Author(s):  
Tabitha Galindo ◽  
Jose Reyna ◽  
Andy Weyer
Keyword(s):  
Rheumatoid Arthritis ◽  
Drug Targets ◽  
Transient Receptor Potential ◽  
Trp Channels ◽  
Receptor Potential ◽  
Trp Channel ◽  
Potential Drug ◽  
Current State ◽  
Transient Receptor ◽  
Potential Drug Targets

Based on clinical and preclinical evidence, Transient Receptor Potential (TRP) channels have emerged as potential drug targets for the treatment of osteoarthritis, rheumatoid arthritis, and gout. This review summarizes the relevant data supporting a role for various TRP channels in arthritis pain and pathogenesis, as well as the current state of pharmacological efforts to ameliorate arthritis symptoms in patient populations.

scholarly journals TRP Channels as Drug Targets to Relieve Itch

2018 ◽  
Vol 11 (4) ◽  
pp. 100 ◽  
Author(s):  
Zili Xie ◽  
Hongzhen Hu
Keyword(s):  
Drug Targets ◽  
Transient Receptor Potential ◽  
Trp Channels ◽  
Current Knowledge ◽  
Receptor Potential ◽  
Protective Role ◽  
Chronic Itch ◽  
Transient Receptor

Although acute itch has a protective role by removing irritants to avoid further damage, chronic itch is debilitating, significantly impacting quality of life. Over the past two decades, a considerable amount of stimulating research has been carried out to delineate mechanisms of itch at the molecular, cellular, and circuit levels. There is growing evidence that transient receptor potential (TRP) channels play important roles in itch signaling. The purpose of this review is to summarize our current knowledge about the role of TRP channels in the generation of itch under both physiological and pathological conditions, thereby identifying them as potential drug targets for effective anti-itch therapies.

scholarly journals TRPV4: an exciting new target to promote alveolocapillary barrier function

2014 ◽  
Vol 307 (11) ◽  
pp. L817-L821 ◽  
Author(s):  
Rory E. Morty ◽  
Wolfgang M. Kuebler
Keyword(s):  
Lung Injury ◽  
Drug Targets ◽  
Transient Receptor Potential ◽  
Trp Channels ◽  
Pulmonary Inflammation ◽  
Receptor Potential ◽  
Blood Oxygenation ◽  
Chlorine Gas ◽  
Transient Receptor ◽  
Gas Exposure

Transient receptor potential (TRP) channels are emerging as important players and drug targets in respiratory disease. Amongst the vanilloid-type TRP channels (which includes the six members of the TRPV family), target diseases include cough, asthma, cancer, and more recently, pulmonary edema associated with acute respiratory distress syndrome. Here, we critically evaluate a recent report that addresses TRPV4 as a candidate target for the management of acute lung injury that develops as a consequence of aspiration of gastric contents, or acute chlorine gas exposure. By use of two new TRPV4 inhibitors (GSK2220691 or GSK2337429A) and a trpv4−/−mouse strain, TRPV4 was implicated as a key mediator of pulmonary inflammation after direct chemical insult. Additionally, applied therapeutically, TRPV4 inhibitors exhibited vasculoprotective effects after chlorine gas exposure, inhibiting vascular leakage, and improving blood oxygenation. These observations underscore TRPV4 channels as candidate therapeutic targets in the management of lung injury, with the added need to balance these against the potential drawbacks of TRPV4 inhibition, such as the danger of limiting the immune response in settings of pathogen-provoked injury.

scholarly journals TRP Channels in Digestive Tract Cancers

2020 ◽  
Vol 21 (5) ◽  
pp. 1877 ◽  
Author(s):  
Paulina Stokłosa ◽  
Anna Borgström ◽  
Sven Kappel ◽  
Christine Peinelt
Keyword(s):  
Digestive Tract ◽  
Drug Targets ◽  
Transient Receptor Potential ◽  
Trp Channels ◽  
Current Knowledge ◽  
Divalent Cations ◽  
Receptor Potential ◽  
Selective Permeability ◽  
Candidate Drug ◽  
Transient Receptor

Cancers of the digestive tract are among the most prevalent types of cancer. These types of cancers are often diagnosed at a late stage, which results in a poor prognosis. Currently, many biomedical studies focus on the role of ion channels, in particular transient receptor potential (TRP) channels, in cancer pathophysiology. TRP channels show mostly non-selective permeability to monovalent and divalent cations. TRP channels are often dysregulated in digestive tract cancers, which can result in alterations of cancer hallmark functions, such as enhanced proliferation, migration, invasion and the inability to induce apoptosis. Therefore, TRP channels could serve as potential diagnostic biomarkers. Moreover, TRP channels are mostly expressed on the cell surface and ion channel targeting drugs do not need to enter the cell, making them attractive candidate drug targets. In this review, we summarize the current knowledge about TRP channels in connection to digestive tract cancers (oral cancer, esophageal cancer, liver cancer, pancreatic cancer, gastric cancer and colorectal cancer) and give an outlook on the potential of TRP channels as cancer biomarkers or therapeutic targets.

The TRP channel superfamily: insights into how structure, protein–lipid interactions and localization influence function

2007 ◽  
Vol 35 (1) ◽  
pp. 77-80 ◽  
Author(s):  
B.J. Reaves ◽  
A.J. Wolstenholme
Keyword(s):  
Cell Biology ◽  
Drug Targets ◽  
Transient Receptor Potential ◽  
Trp Channels ◽  
Receptor Potential ◽  
Trp Channel ◽  
Therapeutic Drug ◽  
Lively Discussion ◽  
Transient Receptor ◽  
The University

TRP (transient receptor potential) cationic channels are key molecules that are involved in a variety of diverse biological processes ranging from fertility to osmosensation and nociception. Increasing our knowledge of these channels will help us to understand a range of physiological and pathogenic processes, as well as highlighting potential therapeutic drug targets. The founding members of the TRP family, Drosophila TRP and TRPL (TRP-like) proteins, were identified within the last two decades and there has been a subsequent explosion in the number and type of TRP channel described. Although information is accumulating as to the function of some of the TRP channels, the activation and inactivation mechanisms, structure, and interacting proteins of many, if not most, are awaiting elucidation. The Cell and Molecular Biology of TRP Channels Meeting held at the University of Bath included speakers working on a number of the different subfamilies of TRP channels and provided a basis for highlighting both similarities and differences between these groups. As the TRP channels mediate diverse functions, this meeting also brought together an audience with wide-ranging research interests, including biochemistry, cell biology, physiology and neuroscience, and inspired lively discussion on the issues reviewed herein.

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