Role of genotype in the adaptation of the brain dopamine system to stress

Dopamine is a neurotransmitter that is produced in the substantia nigra, ventral tegmental area, and hypothalamus of the brain. Dysfunction of the dopamine system has been implicated in different nervous system diseases. The level of dopamine transmission increases in response to any type of reward and by a large number of strongly additive drugs. The role of dopamine dysfunction as a consequence of oxidative stress is involved in health and disease. Introduce new potential targets for the development of therapeutic interventions based on antioxidant compounds. The present review focuses on the therapeutic potential of antioxidant compounds as a coadjuvant treatment to conventional neurological disorders is discussed.

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Characteristics of the brain dopamine system in mice with the neurological quaking mutation

Bulletin of Experimental Biology and Medicine ◽

10.1007/bf00840388 ◽

1988 ◽

Vol 106 (2) ◽

pp. 1159-1162

Author(s):

�. M. Nikulina ◽

Yu. A. Skrinskaya ◽

N. K. Popova

Keyword(s):

Brain Dopamine ◽

Dopamine System ◽

The Brain

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ISDN2014_0049: Effect of GDNF on the brain dopamine system in genetically predisposed to behavioral disorders mouse strains

International Journal of Developmental Neuroscience ◽

10.1016/j.ijdevneu.2015.04.037 ◽

2015 ◽

Vol 47 (Part_A) ◽

pp. 10-10

Author(s):

V.S. Naumenko ◽

E.M. Kondaurova ◽

A.S. Tsybko ◽

T.V. Il'chibaeva ◽

D.V. Bazovkina

Keyword(s):

Behavioral Disorders ◽

Mouse Strains ◽

Brain Dopamine ◽

Dopamine System ◽

The Brain

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Implication of the brain dopamine system in the regulation of genetically-defined aggressive behavior in rats

European Neuropsychopharmacology ◽

10.1016/j.euroneuro.2018.11.827 ◽

2019 ◽

Vol 29 ◽

pp. S556-S557

Author(s):

T. Ilchibaeva ◽

D. Eremin ◽

R. Kozhemyakina ◽

V. Naumenko ◽

A. Tsybko

Keyword(s):

Aggressive Behavior ◽

Brain Dopamine ◽

Dopamine System ◽

The Brain

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Disorders of Sleep and Aggression Trait in Women Associated: What Underlies Staying “Woke”?

Gynecology and Women's Health Research ◽

10.16966/2689-3096.112 ◽

2019 ◽

Vol 1 (1) ◽

Author(s):

Hobgood DK

Keyword(s):

Nervous System ◽

Sleep Apnea ◽

Sympathetic Nervous System ◽

Dopamine System ◽

Patient Falls ◽

Online Test ◽

Sympathetic Nervous ◽

Sleep Centers ◽

The Brain

Narcolepsy is a sleep disorder where the patient falls asleep unwillingly. It is thought to be related to hyper functioning central sleep centers in the brain. Sleep apnea is a disorder of breathing disruption during sleep. Genes of the dopamine system have been implicated with high dopamine: norepinephrine ratio. Since dopamine has also been associated with personality traits, the hypothesis we studied herein was that patients with narcolepsy and sleep apnea would score low in catecholamine settings causing aggression trait. We found that narcolepsy and sleep apnea diagnoses showed significantly lower aggression trait using an online test. The conclusion is that narcolepsy and sleep apnea patients are not aggressive in personality, and since aggressiveness is related to sympathetic nervous system activity, this would be predictable given the role of sympathetic nervous system in wakefulness.

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The Role of Mitochondria in the Genesis of Neuroaxonal Dystrophy in the Brains of Aging Mice

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100115481 ◽

1975 ◽

Vol 33 ◽

pp. 372-373

Author(s):

J.E. Johnson

Keyword(s):

Electron Microscopy ◽

Present Report ◽

Light And Electron Microscopy ◽

Dorsal Column ◽

Neuroaxonal Dystrophy ◽

Nucleus Gracilis ◽

Dystrophic Axons ◽

The Brain ◽

Nucleus Cuneatus

Although neuroaxonal dystrophy (NAD) has been examined by light and electron microscopy for years, the nature of the components in the dystrophic axons is not well understood. The present report examines nucleus gracilis and cuneatus (the dorsal column nuclei) in the brain stem of aging mice.Mice (C57BL/6J) were sacrificed by aldehyde perfusion at ages ranging from 3 months to 23 months. Several brain areas and parts of other organs were processed for electron microscopy.At 3 months of age, very little evidence of NAD can be discerned by light microscopy. At the EM level, a few axons are found to contain dystrophic material. By 23 months of age, the entire nucleus gracilis is filled with dystrophic axons. Much less NAD is seen in nucleus cuneatus by comparison. The most recurrent pattern of NAD is an enlarged profile, in the center of which is a mass of reticulated material (reticulated portion; or RP).

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