Role of p53 in the sensitization of tumor cells to apoptotic cell death

2002 ◽  
Vol 38 (12-13) ◽  
pp. 977-980 ◽  
Author(s):  
Jérôme Thiery ◽  
Hamid Echchakir ◽  
Guillaume Dorothée ◽  
Maya Ameyar-Zazoua ◽  
Heddi Haddada ◽  
...  
Keyword(s):  
Cell Death ◽  
Tumor Cells ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death

Non-apoptotic cell death in malignant tumor cells and natural compounds

2018 ◽  
Vol 420 ◽  
pp. 210-227 ◽  
Author(s):  
Jing Ye ◽  
Ruonan Zhang ◽  
Fan Wu ◽  
Lijuan Zhai ◽  
Kaifeng Wang ◽  
...  
Keyword(s):  
Cell Death ◽  
Tumor Cells ◽  
Malignant Tumor ◽  
Apoptotic Cell ◽  
Natural Compounds ◽  
Apoptotic Cell Death

scholarly journals Chemoproteomic Discovery of a Ritanserin-Targeted Kinase Network Mediating Apoptotic Cell Death of Lung Tumor Cells

2018 ◽  
Vol 94 (5) ◽  
pp. 1246-1255 ◽  
Author(s):  
Sean T. Campbell ◽  
Caroline E. Franks ◽  
Adam L. Borne ◽  
Myungsun Shin ◽  
Liuzhi Zhang ◽  
...  
Keyword(s):  
Cell Death ◽  
Tumor Cells ◽  
Lung Tumor ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death

Apoptosis And Resistance To Anti-Microtubule Agents

1998 ◽  
Vol 4 (S2) ◽  
pp. 1036-1037
Author(s):  
M. C. Willingham
Keyword(s):  
Cell Death ◽  
Tumor Cells ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death ◽  
Mitotic Spindles ◽  
Trade Name ◽  
Anti Cancer ◽  
M Phase ◽  
Target Treatment ◽  
Microtubule Networks

Several clinically important anti-cancer agents exert their effects on tumor cells through interference with the function of microtubules. In addition to the Vinca alkaloids, such as vinblastine and vincristine, the taxanes, such as paclitaxel (Trade Name: Taxol), kill tumor cells through a microtubular target. Treatment with taxol leads to the inability of microtubules to depolymerize, leading to the formation of large intracellular microtubular bundles. In tumor cells that progress through the cell cycle, this leads to the inability of these cells to disassembly interphase microtubule networks and a failure to form functional mitotic spindles. These cells arrest in M phase, from which they eventually progress, either by the induction of apoptotic cell death, or by micronucleation and the formation of tetraploid cells. There is also the possibility that taxol has other effects on the regulation of genes or other systems to enhance cell killing, perhaps through lowering the threshold of cells to the induction of apoptotic cell death.

Role of Apoptotic Cell Death in Sepsis

2003 ◽  
Vol 35 (9) ◽  
pp. 585-592 ◽  
Author(s):  
Richard S. Hotchkiss ◽  
Kevin W. Tinsley ◽  
Irene E. Karl
Keyword(s):  
Cell Death ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death
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