Multifocal Choroiditis and Choroidal Neovascularization Associated with the Multiple Evanescent White Dot and Acute Idiopathic Blind Spot Enlargement Syndrome

We report a 40-year-old Caucasian male presenting sudden bilateral Choroidal Neovascularization (CNV) along with Chorioretinal Lesions (CRL). He presented previous ocular history of relapsing idiopathic bilateral anterior uveitis.

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Neovessel as first manifestation of relapse of associated multifocal choroiditis and MEWDS

International Journal of Retina and Vitreous ◽

10.1186/s40942-019-0175-x ◽

2019 ◽

Vol 5 (1) ◽

Author(s):

Eduardo Morizot ◽

Camila Schiavo Froner

Keyword(s):

Optical Coherence Tomography ◽

Choroidal Neovascularization ◽

Inflammatory Diseases ◽

Clinical Findings ◽

Optical Coherence ◽

Retrospective Case ◽

Multifocal Choroiditis ◽

White Dot Syndrome ◽

Contralateral Eye ◽

The Right

Abstract Purpose To report a case of multifocal choroiditis (MC) that has relapsed as choroidal neovascularization in the contralateral eye followed by a mixed aspect of multiple evanescent white dot syndrome (MEWDS) and MC. Methods Retrospective case report and literature review. The clinical findings were documented by fluorescein angiography, optical coherence tomography, and optical coherence tomography angiography (OCT-A). Results The authors describe the case of a 39-year-old woman with prior ocular history of presumed MEWDS in her left eye, which developed into MC 7 years later in the same eye and 11 years later in the right eye, starting as choroidal neovascularization and developing into MEWDS. OCT-A showed neovessel in a supposedly active MC area outside the macular region in right and left eyes. OCT showed increased choroidal thickness in both eyes and a choroidal neovascularization in the right eye, treated using anti- VEGF therapy. Conclusion This case corroborates the proximity of some inflammatory diseases such as MC and MEWDS. OCT-A has opened new horizons for the better understanding of some retinal diseases by providing more thorough and promising morphological analyses using enhanced tools.

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Optical coherence tomography angiography and choroidal neovascularization in multifocal choroiditis: A descriptive study

European Journal of Ophthalmology ◽

10.1177/1120672118759623 ◽

2018 ◽

Vol 28 (5) ◽

pp. 614-621 ◽

Cited By ~ 4

Author(s):

Cyril Dutheil ◽

Jean-François Korobelnik ◽

Marie-Noëlle Delyfer ◽

Marie-Bénédicte Rougier

Keyword(s):

Optical Coherence Tomography ◽

Choroidal Neovascularization ◽

Morphological Analysis ◽

Optical Coherence Tomography Angiography ◽

Descriptive Study ◽

Optical Coherence ◽

Dead Tree ◽

Dark Ring ◽

Multifocal Choroiditis ◽

Feeder Vessel

Purpose: To analyze the ability of optical coherence tomography angiography to identify choroidal neovascularization in multifocal choroiditis and to describe active and inactive choroidal neovascularization findings. Methods: Retrospective study of consecutive patients with multifocal choroiditis and choroidal neovascularization examined between January and November 2016. In addition to usual exams, optical coherence tomography angiography (AngioPlex™ CIRRUS™ HD-OCT model 5000; Carl Zeiss Meditec, Inc., Dublin, CA, USA) images were assessed for morphological analysis: choroidal neovascularization size, choroidal neovascularization margin (well or poorly circumscribed), choroidal neovascularization shape (tangled or interlacing), choroidal neovascularization core (feeder vessel) and dark ring around the choroidal neovascularization. Results: A total of 10 eyes were included. Optical coherence tomography angiography identified all choroidal neovascularization. Active choroidal neovascularization had well-circumscribed margins (67%), interlacing shape (83%), and a surrounding dark ring (83%). Inactive choroidal neovascularization had rather poorly circumscribed margins (75%), tangled shape, and “dead tree” appearance (50%) with less frequently a surrounding dark ring (50%). Conclusion: Optical coherence tomography angiography is adapted to confirm the diagnosis of choroidal neovascularization complicating multifocal choroiditis, but it is still insufficient to differentiate active and inactive lesions.

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BEVACIZUMAB (AVASTIN) AND RANIBIZUMAB (LUCENTIS) FOR CHOROIDAL NEOVASCULARIZATION IN MULTIFOCAL CHOROIDITIS

Retina ◽

10.1097/iae.0b013e318187aff9 ◽

2009 ◽

Vol 29 (1) ◽

pp. 8-12 ◽

Cited By ~ 58

Author(s):

HOWARD F. FINE ◽

INNA ZHITOMIRSKY ◽

K BAILEY FREUND ◽

GAETANO R. BARILE ◽

BELINDA L. SHIRKEY ◽

...

Keyword(s):

Choroidal Neovascularization ◽

Multifocal Choroiditis

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RESVEGA, a Nutraceutical Omega-3/Resveratrol Supplementation, Reduces Angiogenesis in a Preclinical Mouse Model of Choroidal Neovascularization

International Journal of Molecular Sciences ◽

10.3390/ijms222011023 ◽

2021 ◽

Vol 22 (20) ◽

pp. 11023

Author(s):

Flavie Courtaut ◽

Virginie Aires ◽

Niyazi Acar ◽

Lionel Bretillon ◽

Ida Chiara Guerrera ◽

...

Keyword(s):

Choroidal Neovascularization ◽

Blind Spot ◽

Pleiotropic Effect ◽

Resistance Mechanisms ◽

Age Related Macular Degeneration ◽

Omega 3 Fatty Acids ◽

Omega 3 ◽

Proteomic Approach ◽

Age Related

Age-related macular degeneration (AMD) is an eye disease that is characterized by damage to the central part of the retina, the macula, and that affects millions of people worldwide. At an advanced stage, a blind spot grows in the center of vision, severely handicapping patients with this degenerative condition. Despite therapeutic advances thanks to the use of anti-VEGF, many resistance mechanisms have been found to accentuate the visual deficit. In the present study, we explored whether supplementation with Resvega®, a nutraceutical formulation composed of omega-3 fatty acids and resveratrol, a well-known polyphenol in grapes, was able to counteract laser-induced choroidal neovascularization (CNV) in mice. We highlight that Resvega® significantly reduced CNV in mice compared with supplementations containing omega-3 or resveratrol alone. Moreover, a proteomic approach confirmed that Resvega® could counteract the progression of AMD through a pleiotropic effect targeting key regulators of neoangiogenesis in retina cells in vivo. These events were associated with an accumulation of resveratrol metabolites within the retina. Therefore, a supplementation of omega-3/resveratrol could improve the management or slow the progression of AMD in patients with this condition.

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The “Sponge sign”: A novel feature of inflammatory choroidal neovascularization

European Journal of Ophthalmology ◽

10.1177/1120672120917621 ◽

2020 ◽

pp. 112067212091762

Author(s):

Chiara Giuffrè ◽

Alessandro Marchese ◽

Giovanni Fogliato ◽

Elisabetta Miserocchi ◽

Giulio Maria Modorati ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Choroidal Neovascularization ◽

Choroidal Thickness ◽

Enhanced Depth Imaging ◽

Clinical Activity ◽

Optical Coherence ◽

Punctate Inner Choroidopathy ◽

Myopic Choroidal Neovascularization ◽

Multifocal Choroiditis ◽

Imaging Optical Coherence Tomography

Introduction: To investigate choroidal thickness changes related to the clinical activity of inflammatory choroidal neovascularization in punctate inner choroidopathy/multifocal choroiditis as compared to myopic choroidal neovascularization. Materials and methods: Consecutive inflammatory choroidal neovascularization secondary to punctate inner choroidopathy/multifocal choroiditis, and myopic choroidal neovascularization were retrospectively reviewed. By means of enhanced-depth imaging optical coherence tomography, choroidal thickness was assessed at the same location before choroidal neovascularization development, at choroidal neovascularization onset (baseline), and after treatment. Results: Eleven eyes with inflammatory choroidal neovascularization and 11 eyes with myopic choroidal neovascularization were analyzed. Choroidal thickness beneath inflammatory choroidal neovascularization significantly increased at baseline and decreased after therapy (“Sponge sign”), reaching preclinical values. In particular, mean choroidal thickness under inflammatory choroidal neovascularization was 145 ± 85 µm at the preclinical stage, increased to 210 ± 103 µm at baseline (p = 0.006), and decreased to 136 ± 87 µm after treatment (p = 0.017). Conversely, no significant choroidal thickness changes were disclosed in myopic choroidal neovascularization eyes, under any location. Conclusion: Optical coherence tomography–based choroidal thickness evaluation may represent an additional useful tool to monitor inflammatory choroidal neovascularization activity. Moreover, choroidal thickness under choroidal neovascularizations could be used to discriminate the origin of choroidal neovascular membrane, either inflammatory or myopic, in doubtful cases and guide the therapeutic management.

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