Sudden Bilateral Inflammatory and Neovascular Lesions in Multifocal Choroiditis

We report a 40-year-old Caucasian male presenting sudden bilateral Choroidal Neovascularization (CNV) along with Chorioretinal Lesions (CRL). He presented previous ocular history of relapsing idiopathic bilateral anterior uveitis.

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Choroidal Neovascularization in Multifocal Choroiditis after Dabrafenib and Trametinib

European Journal of Ophthalmology ◽

10.5301/ejo.5001013 ◽

2017 ◽

Vol 27 (6) ◽

pp. e184-e186 ◽

Cited By ~ 3

Author(s):

Giorgia C. Albertini ◽

Eleonora Corbelli ◽

Maurizio Battaglia Parodi ◽

Francesco Bandello

Keyword(s):

Combination Therapy ◽

Metastatic Melanoma ◽

Choroidal Neovascularization ◽

Multimodal Imaging ◽

Vision Loss ◽

Functional Improvement ◽

Multifocal Choroiditis ◽

History Of ◽

The Right

Purpose To describe a case of bilateral choroidal neovascularization (CNV) in multifocal choroiditis (MFC) associated with dabrafenib and trametinib chemotherapy for metastatic melanoma. Case We present a case of a 57-year-old man with MFC who underwent combination therapy with dabrafenib plus trametinib for metastatic melanoma. The patient presented to our ophthalmology department complaining of bilateral vision loss of 2 days’ duration. He underwent multimodal imaging showing a MFC reactivation complicated by bilateral CNV. The patient underwent 3 ranibizumab injections in the right eye and 7 ranibizumab injections in the left eye. Anatomical and functional improvement has been observed. Conclusions This report emphasizes the importance of strict ophthalmologic follow-up in patients with metastatic melanoma treated with dabrafenib plus trametinib since rare severe ocular toxicities can occur, especially in patients with a history of uveitis.

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Faculty Opinions recommendation of Bevacizumab vs photodynamic therapy for choroidal neovascularization in multifocal choroiditis.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.9579956.10240054 ◽

2011 ◽

Author(s):

Chi-Chao Chan ◽

Hatice Nida Sen

Keyword(s):

Photodynamic Therapy ◽

Choroidal Neovascularization ◽

Multifocal Choroiditis

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Oriental Cholangiohepatitis in a Caucasian male

SAGE Open Medical Case Reports ◽

10.1177/2050313x211035573 ◽

2021 ◽

Vol 9 ◽

pp. 2050313X2110355

Author(s):

Laura Suzanne K Suarez ◽

Larnelle N Simms ◽

Khaled Deeb ◽

Curtis E Scott

Keyword(s):

Abdominal Pain ◽

South Korea ◽

Southeast Asia ◽

Biliary Decompression ◽

Caucasian Male ◽

Extensive Evaluation ◽

Recurrent Pyogenic Cholangitis ◽

History Of

Recurrent pyogenic cholangitis (RPC) is a condition found almost exclusively in individuals who lived in Southeast Asia. We report a case of a Caucasian veteran diagnosed with RPC after presenting with a 5-year history of recurrent fevers and abdominal pain 20 years after serving in Japan, South Korea, and Guam. Extensive evaluation led to the diagnosis of RPC with improvement after biliary decompression and antibiotics. Although rare, RPC should be considered in individuals who present with recurrent bouts of abdominal pain and fevers regardless of race.

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Multifocal Choroiditis and Choroidal Neovascularization Associated with the Multiple Evanescent White Dot and Acute Idiopathic Blind Spot Enlargement Syndrome

Ophthalmology ◽

10.1016/s0161-6420(92)31755-5 ◽

1992 ◽

Vol 99 (11) ◽

pp. 1678-1685 ◽

Cited By ~ 59

Author(s):

David Callanan ◽

J. Donald M. Gass

Keyword(s):

Choroidal Neovascularization ◽

Blind Spot ◽

Multifocal Choroiditis

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Neovessel as first manifestation of relapse of associated multifocal choroiditis and MEWDS

International Journal of Retina and Vitreous ◽

10.1186/s40942-019-0175-x ◽

2019 ◽

Vol 5 (1) ◽

Author(s):

Eduardo Morizot ◽

Camila Schiavo Froner

Keyword(s):

Optical Coherence Tomography ◽

Choroidal Neovascularization ◽

Inflammatory Diseases ◽

Clinical Findings ◽

Optical Coherence ◽

Retrospective Case ◽

Multifocal Choroiditis ◽

White Dot Syndrome ◽

Contralateral Eye ◽

The Right

Abstract Purpose To report a case of multifocal choroiditis (MC) that has relapsed as choroidal neovascularization in the contralateral eye followed by a mixed aspect of multiple evanescent white dot syndrome (MEWDS) and MC. Methods Retrospective case report and literature review. The clinical findings were documented by fluorescein angiography, optical coherence tomography, and optical coherence tomography angiography (OCT-A). Results The authors describe the case of a 39-year-old woman with prior ocular history of presumed MEWDS in her left eye, which developed into MC 7 years later in the same eye and 11 years later in the right eye, starting as choroidal neovascularization and developing into MEWDS. OCT-A showed neovessel in a supposedly active MC area outside the macular region in right and left eyes. OCT showed increased choroidal thickness in both eyes and a choroidal neovascularization in the right eye, treated using anti- VEGF therapy. Conclusion This case corroborates the proximity of some inflammatory diseases such as MC and MEWDS. OCT-A has opened new horizons for the better understanding of some retinal diseases by providing more thorough and promising morphological analyses using enhanced tools.

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Is a positive family history of spondyloarthritis relevant for diagnosing axial spondyloarthritis once HLA-B27 status is known?

Rheumatology ◽

10.1093/rheumatology/kez095 ◽

2019 ◽

Vol 58 (9) ◽

pp. 1649-1654 ◽

Cited By ~ 7

Author(s):

Miranda van Lunteren ◽

Désirée van der Heijde ◽

Alexandre Sepriano ◽

Inger J Berg ◽

Maxime Dougados ◽

...

Keyword(s):

Back Pain ◽

Family History ◽

Anterior Uveitis ◽

Chronic Back Pain ◽

Axial Spondyloarthritis ◽

Positive Family History ◽

Hla B27 ◽

Acute Anterior Uveitis ◽

Negative Results ◽

History Of

Abstract Objectives A positive family history (PFH) of spondyloarthritis, in particular a PFH of AS or acute anterior uveitis, is associated with HLA-B27 carriership in chronic back pain patients. As it is unknown, the study aimed to investigate if a PFH contributes to diagnosing axial spondyloarthritis (axSpA) once HLA-B27 status is known. Methods In axSpA-suspected patients from the Assessment of SpondyloArthritis international Society (ASAS), DEvenir des Spondyloarthropathies Indifférenciéés Récentes (DESIR) and SPondyloArthritis Caught Early (SPACE) cohorts, logistic regression analyses were performed with HLA-B27 status and PFH according to the ASAS definition (ASAS-PFH) as determinants and clinical axSpA diagnosis as outcome at baseline. Analyses were repeated with a PFH of AS or acute anterior uveitis. Results In total, 1818 patients suspected of axSpA were analysed (ASAS n = 594, DESIR n = 647, and SPACE n = 577). In patients from the ASAS, DESIR and SPACE cohorts, respectively 23%, 39% and 38% had an ASAS-PFH, 52%, 58% and 43% were HLA-B27 positive, and 62%, 47% and 54% were diagnosed with axSpA. HLA-B27 was independently associated with an axSpA diagnosis in each cohort but an ASAS-PFH was not [ASAS cohort: HLA-B27 odds ratio (OR): 6.9 (95% CI: 4.7, 10.2), ASAS-PFH OR: 0.9 (95% CI: 0.6, 1.4); DESIR: HLA-B27 OR: 2.1 (95% CI: 1.5, 2.9), ASAS-PFH OR: 1.0 (95% CI 0.7, 1.3); SPACE: HLA-B27 OR: 10.4 (95% CI: 6.9, 15.7), ASAS-PFH OR: 1.0 (95% CI: 0.7, 1.5)]. Similar negative results were found for PFH of AS and acute anterior uveitis. Conclusion In three independent cohorts with different ethnical backgrounds, ASAS, DESIR and SPACE, a PFH was not associated independently of HLA-B27 with a diagnosis of axSpA. This indicates that in the vast majority of patients presenting with back pain, a PFH does not contribute to the likelihood of an axSpA diagnosis if HLA-B27 status is known.

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Scrotal Abscess Drained by Iatrogenic Urethral Fistula in an Adult Diabetic Male

Case Reports in Urology ◽

10.1155/2017/9820245 ◽

2017 ◽

Vol 2017 ◽

pp. 1-3 ◽

Cited By ~ 2

Author(s):

Marco Stizzo ◽

Davide Arcaniolo ◽

Carmelo Quattrone ◽

Raffaele Balsamo ◽

Marco Terribile ◽

...

Keyword(s):

Early Detection ◽

Clinical Examination ◽

Improve Outcome ◽

Caucasian Male ◽

Urethral Fistula ◽

Fluoroscopic Control ◽

Catheter Tip ◽

History Of ◽

Scrotal Swelling ◽

Incision Drainage

A 46-year-old Caucasian male has been transferred to our urology department with a history of septic fever, uncompensated diabetes, pain, and scrotal swelling. On clinical examination, the left inguinal and scrotal area was swollen, tender, and painful; scrotal MR had been performed, showing the catheter tip in scrotal cavity and presence of gas. The case was diagnosed as scrotal abscess with urethroscrotal fistula. He was successfully treated with scrotal incision, drainage, catheter repositioning under fluoroscopic control, antibiotics, and insulin. This patient developed an infection of scrotum, which led to subcutaneous abscess getting worse by a poorly controlled glycemia. In this case, an iatrogenic fistula, caused by wrong catheterization, stops the evolving to a Fournier’s Gangrene. Early detection and intervention provide opportunities to improve outcome of this disease.

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Optical coherence tomography angiography and choroidal neovascularization in multifocal choroiditis: A descriptive study

European Journal of Ophthalmology ◽

10.1177/1120672118759623 ◽

2018 ◽

Vol 28 (5) ◽

pp. 614-621 ◽

Cited By ~ 4

Author(s):

Cyril Dutheil ◽

Jean-François Korobelnik ◽

Marie-Noëlle Delyfer ◽

Marie-Bénédicte Rougier

Keyword(s):

Optical Coherence Tomography ◽

Choroidal Neovascularization ◽

Morphological Analysis ◽

Optical Coherence Tomography Angiography ◽

Descriptive Study ◽

Optical Coherence ◽

Dead Tree ◽

Dark Ring ◽

Multifocal Choroiditis ◽

Feeder Vessel

Purpose: To analyze the ability of optical coherence tomography angiography to identify choroidal neovascularization in multifocal choroiditis and to describe active and inactive choroidal neovascularization findings. Methods: Retrospective study of consecutive patients with multifocal choroiditis and choroidal neovascularization examined between January and November 2016. In addition to usual exams, optical coherence tomography angiography (AngioPlex™ CIRRUS™ HD-OCT model 5000; Carl Zeiss Meditec, Inc., Dublin, CA, USA) images were assessed for morphological analysis: choroidal neovascularization size, choroidal neovascularization margin (well or poorly circumscribed), choroidal neovascularization shape (tangled or interlacing), choroidal neovascularization core (feeder vessel) and dark ring around the choroidal neovascularization. Results: A total of 10 eyes were included. Optical coherence tomography angiography identified all choroidal neovascularization. Active choroidal neovascularization had well-circumscribed margins (67%), interlacing shape (83%), and a surrounding dark ring (83%). Inactive choroidal neovascularization had rather poorly circumscribed margins (75%), tangled shape, and “dead tree” appearance (50%) with less frequently a surrounding dark ring (50%). Conclusion: Optical coherence tomography angiography is adapted to confirm the diagnosis of choroidal neovascularization complicating multifocal choroiditis, but it is still insufficient to differentiate active and inactive lesions.

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The impact of certolizumab pegol treatment on the incidence of anterior uveitis flares in patients with axial spondyloarthritis: 48-week interim results from C-VIEW

RMD Open ◽

10.1136/rmdopen-2019-001161 ◽

2020 ◽

Vol 6 (1) ◽

pp. e001161 ◽

Cited By ~ 2

Author(s):

Irene van der Horst-Bruinsma ◽

Rianne van Bentum ◽

Frank D Verbraak ◽

Thomas Rath ◽

James T Rosenbaum ◽

...

Keyword(s):

Incidence Rate ◽

Anterior Uveitis ◽

Poisson Regression ◽

Axial Spondyloarthritis ◽

Certolizumab Pegol ◽

Tnf Inhibitor ◽

Open Label ◽

Before And After ◽

History Of ◽

The Impact

BackgroundAcute anterior uveitis (AAU) is the most common extra-articular manifestation in patients with axial spondyloarthritis (axSpA). C-VIEW investigates the impact of the Fc-free TNF inhibitor certolizumab pegol (CZP) on AAU flares in patients with active axSpA at high risk of recurrent AAU.MethodsC-VIEW (NCT03020992) is a 96-week ongoing, multicentre, open-label, phase 4 study. Included patients had an axSpA diagnosis, a history of recurrent AAU (≥2 AAU flares, ≥1 flare in the year prior to study entry), HLA-B27 positivity, active disease, and failure of ≥2 non-steroidal anti-inflammatory drugs. Patients received CZP 400 mg at Weeks 0/2/4, then 200 mg every 2 weeks up to 96 weeks. This 48-week pre-planned interim analysis compares AAU flare incidence in the 48 weeks before and after initiation of CZP treatment, using Poisson regression to account for possible within-patient correlations.ResultsIn total, 89 patients were included (male: 63%; radiographic/non-radiographic axSpA: 85%/15%; mean axSpA disease duration: 8.6 years). During 48 weeks’ CZP treatment, 13 (15%) patients experienced 15 AAU flares, representing an 87% reduction in AAU incidence rate (146.6 per 100 patient-years (PY) in the 48 weeks pre-baseline to 18.7 per 100 PY during CZP treatment). Poisson regression analysis showed that the incidence rate of AAU per patient reduced from 1.5 to 0.2 (p<0.001). No new safety signals were identified.ConclusionsThere was a significant reduction in the AAU flare rate during 48 weeks of CZP treatment, indicating that CZP is a suitable treatment option for patients with active axSpA and a history of recurrent AAU.

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