Context and tone conditioning are selectively impaired by ethanol in the preweanling rat: Effects of dose and time of administration

1994 ◽  
Vol 62 (3) ◽  
pp. 201-209 ◽  
Author(s):  
David L. McKinzie ◽  
Jieun Lee ◽  
Jamie H. Bronfen ◽  
Linda P. Spear ◽  
Norman E. Spear
Keyword(s):  
Time Of Administration

Application of melatonin for prevention and treatment of circadian rhythm disorders

2021 ◽  
Vol 19 (2) ◽  
pp. 34-38
Author(s):  
A. S. SAMOYLOV ◽  
◽  
N. V. RYLOVA ◽  
A. V. ZHOLINSKIY ◽  
I. V. BOLSHAKOV ◽  
...  
Keyword(s):  
Circadian Rhythm ◽  
Side Effects ◽  
Light Exposure ◽  
The Body ◽  
Optimal Dosage ◽  
Vital Activity ◽  
Time Zone ◽  
Prevention And Treatment ◽  
Time Of Administration ◽  
Circadian Rhythm Disorders

The article presents data from the Russian and foreign literature of the properties of melatonin, its role in the vital activity of the body and the regulation of circadian rhythms. The features of using the drug in desynchronosis, the optimal dosage and time of administration, as well as the possibility of its use in combination with non-pharmacological treatment methods are discussed. These methods include dosed light exposure and exercise. Additionally, new studies are considered, indicating the beneficial effect of melatonin and its agonists on the immune, cardiovascular, endocrine and nervous systems. Based on the collected data, it is asserted that melatonin can significantly accelerate the process of adaptation to a new time zone without the development of side effects. Therefore, this drug is the most effective and safe treatment for desynchronosis. It is also important to note that the study of the multifaceted effects of melatonin on body functions opens up great prospects in the treatment of many diseases.

Effects of Time of Administration and Posture on the Pharmacokinetics of Cefprozil

1993 ◽  
Vol 25 (3) ◽  
pp. 237-242 ◽  
Author(s):  
Wen Chyi Shyu ◽  
Carol R. Gleason ◽  
Rashmi H. Barbhaiya
Keyword(s):  
Time Of Administration

scholarly journals The Diagnostic Value of the Glucose Curve in Individuals with and without Diabetes

2019 ◽  
pp. 1-7
Author(s):  
Mohamed S. El-Gareb ◽  
Mohamed N. El-Naggar
Keyword(s):  
Blood Sample ◽  
Glycated Haemoglobin ◽  
Diagnostic Value ◽  
Control Group ◽  
Diabetic Patients ◽  
Measured Concentration ◽  
Normal Individuals ◽  
Edta Tube ◽  
Time Of Administration ◽  
Glucose Curve

Aim: Of this study is to demonstrate the importance of glucose curve test in monitoring pre and post-meal variation in diabetic and normal individuals. Methodology: The individuals subjected to this study mainly grouped in two categories the (DM2 group) and the (Control group), they instructed to came fasting at which blood sample will be collected in EDTA and blank tube then after 30 min. the first post-prandial blood sample collected and then after every 1,2,3,4,5,6,7,8 hours blood sample collected subsequently, then serum separated from each sample (except the EDTA tube) analysed biochemically for glucose and glycated haemoglobin HbA1c (from EDTA tube). Result: We found that, the calculated glucose based on mean glycated haemoglobin HbA1c% results underestimate the real concentrations all over the glucose curve in control group but in DM2 group it underestimate the mean and some actually measured concentration in some points of the curve which adds more burden on the diabetic patient and the responsibility of adjusting the dose and time of administration. Conclusion: from our prospect we recommend the use of blood glucose curve as a monitoring and diagnostic tool generally for glucose metabolism in normal, pre-diabetic, diabetic and uncontrolled diabetic patients before and during therapeutic conditions.

scholarly journals The efficacy and safety of interferons for the treatment of patients with COVID-19: protocol for systematic review and meta-analysis of controlled trials

2021 ◽  
Author(s):  
Afsaneh Noormandi ◽  
Mohammad Fathalipour ◽  
Reza Daryabeygi-Khotbehsara ◽  
Soheil Hassanipour
Keyword(s):  
Systematic Review ◽  
Clinical Trials ◽  
Meta Analysis ◽  
World Health ◽  
Controlled Trials ◽  
Efficacy And Safety ◽  
Global Pandemic ◽  
The World ◽  
Health Organization ◽  
Time Of Administration

Background and objective: COVID-19 has since been declared a global pandemic by the World Health Organization (WHO), infecting millions worldwide. The use of Interferon (INF) subtypes previously examined in the treatment of SARS and MERS is also being initiated in some clinical trials. Although different clinical trials were evaluated IFNs in the treatment of COVID-19, their efficacy and safety remain unknown. Therefore, this study aims to systematically assess IFNs efficacy and safety in treating patients with COVID-19. Methods: The protocol has been registered in the PROSPERO International Prospective Register (CRD42020200643) on 24 July 2020. This protocol has been arranged according to the PRISMA-P (Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols) 2015 checklist. Discussion: Due to lack of approved medication for the covid-19 treatment and also various mutations of this virus, evaluated the efficacy and safety of medications by various studies could help for finding treatments with high effectiveness. IFNs are one of the medications that have been administered in covid-19 infection.  Moreover, the best time of administration and dose of this medication was unknown. Although meta-analysis is a potent source for assessing the accuracy of subjects, heterogeneity of articles is a potent limitation of our work.

scholarly journals The compliance of surgical prophylactic antibiotics with standard protocols in Imam Reza teaching hospital of Birjand, Iran

2021 ◽  
Author(s):  
Azade Ebrahimzadeh ◽  
Mohammad Najafi ◽  
Bita Bijari ◽  
Ahmad Amouzeshi ◽  
Mohammad Reza Abedini ◽  
...  
Keyword(s):  
Teaching Hospital ◽  
Orthopedic Surgery ◽  
Analytical Study ◽  
Prophylactic Antibiotics ◽  
Standard Protocol ◽  
Validity And Reliability ◽  
Drug Type ◽  
Time Of Administration ◽  
Surgical Operations ◽  
Type Of Surgery

Background and Objectives: Taking unnecessary or inappropriate prophylactic antibiotics can cause infections with re- sistant organisms. The present study aimed to investigate administration prophylactic antibiotics in surgery ward and its compliance with standard protocol in Imam Reza teaching hospital of Birjand, Iran. Materials and Methods: This descriptive-analytical study was performed to evaluate the pattern of prophylactic antibiotics on patients who underwent surgical operations from October to December 2019. A checklist including demographic informa- tion, type of prophylactic antibiotics, dose and duration of using drug, type of surgery, and compliance with standard protocol was used. The validity and reliability of the checklist were evaluated and confirmed prior to the study. All eligible patients were enrolled and the information of the prescribed drugs in the surgical wards was compared with the Schwartz’s principles of surgery as standard protocol. Results: Out of a total of 300 patients, 187 (62.3%) were male. Among the patients, 155 (51.7%) cases underwent general surgery, 119 (39.6%) cases orthopedic surgery, and 26 (8.7%) cases neurosurgery. The most popular prescribed antibiotics were cefazolin (170 cases) and ceftriaxone + metronidazole (67 cases). Furthermore, the maximum antibiotic administrations were two days (127 cases) and one day (93 cases). More importantly, 67.7% and 92.3% of the patients were in compliance with the standard protocol in terms of the type and time of administration, respectively. Conclusion: Our results showed that duration and route of administrating antibiotics were consistent with the standard pro- tocol, but the type of drugs and indication did not match.

The Action of Chelating Agents in Experimental Uranium Intoxication in Mice: Variations with Structure and Time of Administration

1992 ◽  
Vol 19 (3) ◽  
pp. 350-357
Author(s):  
JOSÉ L. DOMINGO ◽  
M. TERESA COLOMINA ◽  
JUAN M. LLOBET ◽  
MARK M. JONES ◽  
PRAMOD K. SINGH ◽  
...  
Keyword(s):  
Chelating Agents ◽  
Time Of Administration
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