The Nearchus project: Antibiotic susceptibility of respiratory pathogens and clinical outcome in lower respiratory tract infections at 27 centres in the UK

BACKGROUND: The clinical relevance of specimens from the lower airways is often debatable. However, they are most commonly examined for diagnosing lower respiratory tract infections (LRTIs).AIM: This study aimed to determine the diagnostic value of sputum quality assessment about sputum culture for diagnosing LRTIs in children.METHODS: In six months, a total of 1485 sputum samples were quality assessed by using Bartlett’s grading system. All samples, regardless of their quality, were cultured, identified, and antimicrobial susceptibility testing was performed by Kirby-Bauer disc-diffusion method.RESULTS: Among the acceptable category, defined by Bartlett’s grading system, 132 (63.2%) samples showed culture positivity of which Streptococcus pneumoniae 48 (36.4%) was most commonly isolated, followed by Moraxella catarrhalis 22 (16.7%) and Haemophilus influenza 21 (15.9%). Among the non-acceptable category, 185 (14.5%) samples were culture positive of which most commonly isolated were Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa with 64 (34.6%), 54 (29.2%) and 28 (15.1%), respectively.CONCLUSION: Sputum quality assessment is a useful tool for distinguishing the true respiratory pathogens from possible colonising flora for which antibiotic treatment should not be highly considered.

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Epidemiology of Respiratory Pathogens in Children with Lower Respiratory Tract Infections in Shanghai, China, from 2013 to 2015

Japanese Journal of Infectious Diseases ◽

10.7883/yoken.jjid.2017.323 ◽

2018 ◽

Vol 71 (1) ◽

pp. 39-44 ◽

Cited By ~ 10

Author(s):

Pengcheng Liu ◽

Menghua Xu ◽

Leiyan He ◽

Liyun Su ◽

Aimin Wang ◽

...

Keyword(s):

Respiratory Tract ◽

Lower Respiratory Tract ◽

Respiratory Tract Infections ◽

Respiratory Pathogens ◽

Lower Respiratory Tract Infections ◽

Tract Infections

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A prospective study of prevalence of anti-microbial susceptibility of bacterial isolates in lower respiratory tract infections

International Journal of Basic & Clinical Pharmacology ◽

10.18203/2319-2003.ijbcp20212917 ◽

2021 ◽

Vol 10 (8) ◽

pp. 915

Author(s):

Ajaz Husaain ◽

Qursheed Sultana ◽

M. Abdur Rab Ansari

Keyword(s):

Antibiotic Resistance ◽

Respiratory Tract ◽

Antibiotic Susceptibility ◽

Lower Respiratory Tract ◽

Respiratory Tract Infections ◽

Tertiary Care ◽

Care Hospital ◽

Lower Respiratory Tract Infections ◽

Mortality And Morbidity ◽

Tract Infections

Background: Lower respiratory tract infections (LRTIs) is one of the most common causes of mortality and morbidity across all age groups. In recent years, antibiotic resistance is constantly increasing. Thus, there is a need to monitor the bacteriological profile of pathogenic organisms. The present study aims to identify bacterial pathogens and their antibiotic susceptibility pattern.Methods: A prospective, observational, single centered study was conducted at tertiary care hospital for a period of 1 year i.e. from March 2016 to March 2017. A total of 733 sputum samples were collected and analyzed in microbiology lab. The samples went subjected to microscopy testing, culture and antibiotic sensitivity using suitable bacteriological methods.Results: From 733 sputum samples, about 51.34% were males and 48.56% were females. Approximately 49.65% of total samples were growth positive. Klebsiella was found to be the predominant microorganism followed by Methicillin sensitive Staphylococcus aureus (MSSA) and streptococcus. The gram-negative bacteria showed highest sensitivity for piperacillin/tazobactam, imipenem and ciprofloxacin. The gram-positive bacteria were found to be more susceptible for vancomycin, teicoplanin and amikacin.Conclusions: LRTIs are contagious form of disease and can rapidly disseminate among community. The irrational use of antibiotics complicates the management due to the antibiotic resistance. Local trend of antibiotic susceptibility pattern should be known as it helps in increasing the appropriate use of the antibiotics, decreasing the mortality and morbidity and reduces the anti-microbial resistance.

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