Immune response of neonatal specific pathogen-free cats to experimental infection with Bartonella henselae

1999 ◽  
Vol 71 (3-4) ◽  
pp. 233-243 ◽  
Author(s):  
Lynn Guptill ◽  
Leonard Slater ◽  
Ching-Ching Wu ◽  
Lawrence T Glickman ◽  
Tsang-Long Lin ◽  
...  
Keyword(s):  
Immune Response ◽  
Experimental Infection ◽  
Bartonella Henselae ◽  
Specific Pathogen Free ◽  
Specific Pathogen

scholarly journals Experimental infection of specific pathogen free (SPF) cats with two different strains of Bartonella henselae type I: A comparative study

2002 ◽  
Vol 33 (6) ◽  
pp. 669-684 ◽  
Author(s):  
Kazuhiro Yamamoto ◽  
Bruno B. Chomel ◽  
Rickie W. Kasten ◽  
Carrie M. Hew ◽  
David K. Weber ◽  
...  
Keyword(s):  
Comparative Study ◽  
Experimental Infection ◽  
Bartonella Henselae ◽  
Type I ◽  
Specific Pathogen Free ◽  
Specific Pathogen ◽  
Different Strains

Fowl adenovirus (FAdV) serotype 4 causes depletion of B and T cells in lymphoid organs in specific pathogen-free chickens following experimental infection

2008 ◽  
Vol 121 (1-2) ◽  
pp. 130-139 ◽  
Author(s):  
Esther Schonewille ◽  
Amarjit Singh ◽  
Thomas W. Göbel ◽  
Wilhelm Gerner ◽  
Armin Saalmüller ◽  
...  
Keyword(s):  
T Cells ◽  
Experimental Infection ◽  
Lymphoid Organs ◽  
Specific Pathogen Free ◽  
Fowl Adenovirus ◽  
Specific Pathogen

scholarly journals Specific-Pathogen-Free Pigs as an Animal Model for Studying Chlamydia trachomatis Genital Infection

2005 ◽  
Vol 73 (12) ◽  
pp. 8317-8321 ◽  
Author(s):  
Daisy Vanrompay ◽  
Thi Q. T. Hoang ◽  
Liselotte De Vos ◽  
Kristel Verminnen ◽  
Taher Harkinezhad ◽  
...  
Keyword(s):  
Immune Response ◽  
Animal Model ◽  
Chlamydia Trachomatis ◽  
Immunoglobulin M ◽  
Large Animal Model ◽  
Genital Infection ◽  
Large Animal ◽  
Specific Pathogen Free ◽  
Humoral Immune ◽  
Specific Pathogen

ABSTRACT The purpose of the present study was to evaluate pigs as a large-animal model for female genital infection with two Chlamydia trachomatis human serovar E strains. Sixteen-week-old specific-pathogen-free female pigs (gilts) were intravaginally infected with the trachoma type E reference strain Bour or the urogenital serovar E strain 468. Several conclusions can be drawn from our findings on the pathogenicity of a primary C. trachomatis genital infection in gilts. First of all, we demonstrated that the serovar E strains Bour and 468 could ascend in the genital tract of gilts. The serovar E strains could replicate in the superficial columnar cervical epithelium and in the superficial epithelial layer of the uterus, which are known to be the specific target sites for a C. trachomatis genital infection in women. Second, inflammation and pathology occurred at the replication sites. Third, the organisms could trigger a humoral immune response, as demonstrated by the presence of immunoglobulin M (IgM), IgG, and IgA in both serum and genital secretion samples. Our findings imply that the pig model might be useful for studying the pathology, pathogenesis, and immune response to a C. trachomatis infection of the genital system.

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