Dicentric (9;20)(p11;q11) identified by fluorescence in situ hybridization in four pediatric acute lymphoblastic leukemia patients

1996 ◽  
Vol 92 (2) ◽  
pp. 111-115 ◽  
Author(s):  
Nyla A. Heerema ◽  
Kathleen D. Maben ◽  
Jonathan Bernstein ◽  
Philip P. Breitfeld ◽  
Richard S. Neiman ◽  
...  
Keyword(s):  
In Situ Hybridization ◽  
Acute Lymphoblastic Leukemia ◽  
Fluorescence In Situ Hybridization ◽  
Lymphoblastic Leukemia ◽  
Pediatric Acute Lymphoblastic Leukemia

scholarly journals Cytogenetic and Fluorescence In Situ Hybridization (FISH) Profile of Pediatric Acute Lymphoblastic Leukemia (ALL) in a University Hospital in South India

2021 ◽  
Author(s):  
Latha Sneha Magatha ◽  
Julius Xavier Scott ◽  
Gayathri Subramaniam ◽  
Thirugnanasambandan Chandrasekaran ◽  
Solomon Franklin Durairaj Paul ◽  
...  
Keyword(s):  
In Situ Hybridization ◽  
Acute Lymphoblastic Leukemia ◽  
Fluorescence In Situ Hybridization ◽  
South India ◽  
Lymphoblastic Leukemia ◽  
University Hospital ◽  
Pediatric Acute Lymphoblastic Leukemia

Fluorescence in situ hybridization analysis of the cryptic t(12;21) (p13;q22) in childhood B-lineage acute lymphoblastic leukemia

2002 ◽  
Vol 132 (1) ◽  
pp. 61-64 ◽  
Author(s):  
Orly Yehuda-Gafni ◽  
Gabriel Cividalli ◽  
Ayala Abrahmov ◽  
Michael Weintrob ◽  
Susana Ben Neriah ◽  
...  
Keyword(s):  
In Situ Hybridization ◽  
Acute Lymphoblastic Leukemia ◽  
Fluorescence In Situ Hybridization ◽  
Lymphoblastic Leukemia ◽  
Hybridization Analysis ◽  
B Lineage

Detection of ETV6 and RUNX1 gene rearrangements using fluorescence in situ hybridization in Mexican patients with acute lymphoblastic leukemia: experience at a single institution

2005 ◽  
Vol 162 (2) ◽  
pp. 140-145 ◽  
Author(s):  
Patricia Pérez-Vera ◽  
Oreth Montero-Ruiz ◽  
Sara Frías ◽  
Verónica Ulloa-Avilés ◽  
Rocío Cárdenas-Cardós ◽  
...  
Keyword(s):  
In Situ Hybridization ◽  
Acute Lymphoblastic Leukemia ◽  
Fluorescence In Situ Hybridization ◽  
Lymphoblastic Leukemia ◽  
Gene Rearrangements ◽  
Single Institution ◽  
Runx1 Gene ◽  
Mexican Patients

scholarly journals A New Subtype of Pre-B Acute Lymphoblastic Leukemia With t(5; 12)(q31q33; p12), Molecularly and Cytogenetically Distinct From t(5; 12) in Chronic Myelomonocytic Leukemia

Blood ◽  
1997 ◽  
Vol 89 (5) ◽  
pp. 1716-1722 ◽  
Author(s):  
Iwona Wlodarska ◽  
Anna Aventı́n ◽  
Júlia Inglés-Esteve ◽  
Daniela Falzetti ◽  
Arnold Criel ◽  
...  
Keyword(s):  
In Situ Hybridization ◽  
Acute Lymphoblastic Leukemia ◽  
Fluorescence In Situ Hybridization ◽  
Cell Lines ◽  
Chromosomal Abnormality ◽  
Gene Fusion ◽  
Lymphoblastic Leukemia ◽  
Chronic Myelomonocytic Leukemia ◽  
Myelomonocytic Leukemia

Abstract Translocation t(5; 12)(q33; p13), resulting in an ETV6/PDGFRB gene fusion, is a recurrent chromosomal abnormality associated with chronic myelomonocytic leukemia (CMML). An analogous translocation was also found in four cell lines with features of pre-B acute lymphoblastic leukemia (ALL). Using fluorescence in situ hybridization (FISH) we show here that in three of these cell lines identical complex rearrangements occurred. However, the regions involved on 5q and 12p are different from the breakpoints in CMML, and the translocation is accompanied by seemingly identical cryptic deletions of both 5q and 12p chromosome sequences in all analyzed pre-B ALL cell lines. The similar cytogenetic, FISH, and immunophenotyping findings in the three cell lines suggest that the t(5; 12)(q31q33; p12) defines a new entity of pre-B ALL.

A fluorescence in situ hybridization study of TEL-AML1 fusion gene in B-cell acute lymphoblastic leukemia (1984–2001)

2003 ◽  
Vol 144 (2) ◽  
pp. 143-147 ◽  
Author(s):  
Nathalie Douet-Guilbert ◽  
Frédéric Morel ◽  
Marie-Josée Le Bris ◽  
Angèle Herry ◽  
Geneviève Le Calvez ◽  
...  
Keyword(s):  
In Situ Hybridization ◽  
Acute Lymphoblastic Leukemia ◽  
B Cell ◽  
Fluorescence In Situ Hybridization ◽  
Fusion Gene ◽  
Lymphoblastic Leukemia ◽  
Hybridization Study ◽  
Cell Acute Lymphoblastic Leukemia

Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia Is Separated into Two Subgroups Associated with Survival by BCR-ABL Fluorescence in situ Hybridization of Segmented Cell Nuclei: Report from a Single Institution

2016 ◽  
Vol 136 (3) ◽  
pp. 157-166 ◽  
Author(s):  
Yoshimasa Kamoda ◽  
Kiyotaka Izumi ◽  
Futoshi Iioka ◽  
Takashi Akasaka ◽  
Fumihiko Nakamura ◽  
...  
Keyword(s):  
In Situ Hybridization ◽  
Acute Lymphoblastic Leukemia ◽  
Fluorescence In Situ Hybridization ◽  
Lymphoblastic Leukemia ◽  
Philadelphia Chromosome ◽  
Cell Nuclei ◽  
Fish Group ◽  
Segmented Cell ◽  
Philadelphia Chromosome Positive

Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL) may include the lymphoid blast crisis of chronic myeloid leukemia (CML-BC). We applied fluorescence in situ hybridization (FISH) of the BCR-ABL fusion gene to peripheral blood and/or bone marrow smears to determine whether the fusion was restricted to mononuclear cell nuclei or if segmented cell nuclei representing mature neutrophils also carried the fusion (Seg-FISH). Among 20 patients with Ph+ ALL without a prior diagnosis of CML, 9 were Seg-FISH+ and 11 were Seg-FISH-. Seg-FISH+ cases were characterized by a higher rate of p210-type BCR-ABL transcripts, higher white cell and blast counts, and a higher rate of myeloid and T-lymphoid antigen expression than Seg-FISH- cases, in addition to ‘major route' cytogenetic abnormalities associated with CML-BC. Eighteen patients were treated with tyrosine kinase inhibitors (TKIs) either alone or in combination with multiagent chemotherapy, and 7 underwent allogeneic hematopoietic stem cell transplantation. Progression-free and overall survivals were greater in the Seg-FISH+ group than in the Seg-FISH- group. These results suggest that the Seg-FISH+ group represents lymphoid CML-BC that occurs de novo, while the Seg-FISH- represents Ph+ ALL in the strict sense, and the two groups are associated with survival when treated with TKIs or TKI-combined therapy.

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