Gap Junction-Mediated Intercellular Signaling in Health and Disease

1999 ◽  
Vol 22 (10) ◽  
pp. 479-480
Author(s):  
David C. Spray
Keyword(s):  
Gap Junction ◽  
Intercellular Signaling ◽  
Health And Disease

scholarly journals Exosomes as Intercellular Signaling Organelles Involved in Health and Disease: Basic Science and Clinical Applications

2013 ◽  
Vol 14 (3) ◽  
pp. 5338-5366 ◽  
Author(s):  
Chiara Corrado ◽  
Stefania Raimondo ◽  
Antonio Chiesi ◽  
Francesco Ciccia ◽  
Giacomo De Leo ◽  
...  
Keyword(s):  
Basic Science ◽  
Clinical Applications ◽  
Intercellular Signaling ◽  
Health And Disease ◽  
Signaling Organelles

scholarly journals Bioactive Lipids in MSCs Biology: State of the Art and Role in Inflammation

2021 ◽  
Vol 22 (3) ◽  
pp. 1481
Author(s):  
Sara Casati ◽  
Chiara Giannasi ◽  
Stefania Niada ◽  
Roberta F. Bergamaschi ◽  
Marica Orioli ◽  
...  
Keyword(s):  
State Of The Art ◽  
Comprehensive Analysis ◽  
Intercellular Signaling ◽  
Structural Components ◽  
Bioactive Lipids ◽  
Targeted Metabolomics ◽  
Multipotent Cells ◽  
Lipid Species ◽  
Health And Disease ◽  
Heterogenous Population

Lipidomics is a lipid-targeted metabolomics approach that aims to the comprehensive analysis of lipids in biological systems in order to highlight the specific functions of lipid species in health and disease. Lipids play pivotal roles as they are major structural components of the cellular membranes and energy storage molecules but also, as most recently shown, they act as functional and regulatory components of intra- and intercellular signaling. Herein, emphasis is given to the recently highlighted roles of specific bioactive lipids species, as polyunsaturated fatty acids (PUFA)-derived mediators (generally known as eicosanoids), endocannabinoids (eCBs), and lysophospholipids (LPLs), and their involvement in the mesenchymal stem cells (MSCs)-related inflammatory scenario. Indeed, MSCs are a heterogenous population of multipotent cells that have attracted much attention for their potential in regulating inflammation, immunomodulatory capabilities, and reparative roles. The lipidomics of the inflammatory disease osteoarthritis (OA) and the influence of MSCs-derived lipids have also been addressed.

Effect of sound on gap-junction-based intercellular signaling: Calcium waves under acoustic irradiation

2015 ◽  
Vol 92 (5) ◽  
Author(s):  
P. A. Deymier ◽  
N. Swinteck ◽  
K. Runge ◽  
A. Deymier-Black ◽  
J. B. Hoying
Keyword(s):  
Gap Junction ◽  
Calcium Waves ◽  
Intercellular Signaling

Gap-Junction Proteins in Retinal Development: New Roles for the “Nexus”

Physiology ◽  
2009 ◽  
Vol 24 (4) ◽  
pp. 219-230 ◽  
Author(s):  
Jeremy E. Cook ◽  
David L. Becker
Keyword(s):  
Cell Signaling ◽  
Gap Junction ◽  
Retinal Development ◽  
Transcriptional Networks ◽  
Cytoplasmic Proteins ◽  
Neuronal Types ◽  
Health And Disease ◽  
Gap Junction Proteins ◽  
Vertebrate Central Nervous System ◽  
Junction Proteins

Gap-junction channels, the cytoplasmic proteins that associate with them, and the transcriptional networks that regulate them are increasingly being viewed as critical communications hubs for cell signaling in health and disease. As a result, the term “nexus,” which was the original structural name for these focal intercellular links, is coming back into use with new proteomic and transcriptomic meanings. The retina is better understood than any other part of the vertebrate central nervous system in respect of its developmental patterning, its diverse neuronal types and circuits, and the emergence of its definitive structure-function correlations. Thus, studies of the junctional and nonjunctional nexus roles of gap-junction proteins in coordinating retinal development should throw useful light on cell signaling in other developing nervous tissues.

Plasma Membrane Channels Formed by Connexins: Their Regulation and Functions

2003 ◽  
Vol 83 (4) ◽  
pp. 1359-1400 ◽  
Author(s):  
JUAN C. SÁEZ ◽  
VIVIANA M. BERTHOUD ◽  
MARÍA C. BRAÑES ◽  
AGUSTÍN D. MARTÍNEZ ◽  
ERIC C. BEYER
Keyword(s):  
Plasma Membrane ◽  
Gap Junction ◽  
Protein Trafficking ◽  
Genetic Diseases ◽  
Physiological Role ◽  
Channel Structure ◽  
Membrane Channels ◽  
Intercellular Signaling ◽  
Gap Junction Channels ◽  
Extracellular Milieu

Sáez, Juan C., Viviana M. Berthoud, María C. Brañes, Agustín D. Martínez, and Eric C. Beyer. Plasma Membrane Channels Formed by Connexins: Their Regulation and Functions. Physiol Rev 83: 1359-1400, 2003; 10.1152/physrev.00007.2003.—Members of the connexin gene family are integral membrane proteins that form hexamers called connexons. Most cells express two or more connexins. Open connexons found at the nonjunctional plasma membrane connect the cell interior with the extracellular milieu. They have been implicated in physiological functions including paracrine intercellular signaling and in induction of cell death under pathological conditions. Gap junction channels are formed by docking of two connexons and are found at cell-cell appositions. Gap junction channels are responsible for direct intercellular transfer of ions and small molecules including propagation of inositol trisphosphate-dependent calcium waves. They are involved in coordinating the electrical and metabolic responses of heterogeneous cells. New approaches have expanded our knowledge of channel structure and connexin biochemistry (e.g., protein trafficking/assembly, phosphorylation, and interactions with other connexins or other proteins). The physiological role of gap junctions in several tissues has been elucidated by the discovery of mutant connexins associated with genetic diseases and by the generation of mice with targeted ablation of specific connexin genes. The observed phenotypes range from specific tissue dysfunction to embryonic lethality.

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